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RIPK1: receptor interacting serine/threonine kinase 1

1 protein, 47 patents, 1 drug, 4 trials, 5,044 NIH grants and 10,947 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolRIPK1HGNC
Namereceptor interacting serine/threonine kinase 1HGNC
NCBI Gene ID8737NCBI Gene
HGNC IDHGNC:10019HGNC
EnsemblENSG00000137275NCBI Gene
AliasesAIEFL, IMD57, RIP, RIP-1, RIP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13546Receptor-interacting serine/threonine-protein kinase 167139Ensembl, GeneID, HGNCUniProt

Patents 47

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-191764Q13546Espacenet
EP 4641201 A22025-10-291357Q13546Espacenet
JP 2025147176 A2025-10-0616539Q13546Espacenet
JP 2025517969 A2025-06-121357Q13546Espacenet
JP 2025517970 A2025-06-121764Q13546Espacenet
KR 1020250067241 A2025-05-152Q13546Espacenet
JP 2025028160 A2025-02-2816539Q13546Espacenet
KR 1020250010750 A2025-01-2116539Q13546Espacenet
JP 2024534853 A2024-09-26103Q13546Espacenet
JP 2024109657 A2024-08-1416378Q13546Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GSK2982772CHEMBL4071864Receptor-interacting serine/threonine-protein kinase 1 inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04316585GSK2982772PHASE12024-03-18ClinicalTrials.gov
NCT02903966GSK2982772PHASE22020-06-11ClinicalTrials.gov
NCT02858492GSK2982772PHASE22019-11-01ClinicalTrials.gov
NCT02776033GSK2982772PHASE22019-08-22ClinicalTrials.gov

NIH grants 5044

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01AI124346Innate immune signaling and stress response382,025NIH's project files
R37AI101935Inflammatory Caspases in Innate Immunity and Inflammation362,025NIH's project files
P30CA016672Cancer Center Support Grant302,025NIH's project files
R35CA253095Innate immune sensors, inflammasomes, and inflammasome-mediated processes in cancer232,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase222,025NIH's project files
P30CA008748Cancer Center Support Grant222,025NIH's project files
ZIASC010376TNF Signaling, Cell Death and Cancer212,025NIH's project files
R37AI044828Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension202,025NIH's project files
R01AI160179Targeting innate immune pathways, and inflammatory cell death in cytokine-mediated diseases172,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)162,025NIH's project files

Papers 10947

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820461PubTator, text miningPubMed
42817092PubTator, text miningPubMed
42812611PubTator, text miningPubMed
42811115PubTator, text miningPubMed
42808676PubTator, text miningPubMed
42806174PubTator, text miningPubMed
42805596PubTator, text miningPubMed
42794787PubTator, text miningPubMed
42789950PubTator, text miningPubMed
42789717PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license