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Gene · 8740

TNFSF14: TNF superfamily member 14

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNFSF14: TNF superfamily member 14. Genes, record 8740. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8740

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Gene

Symbol
TNFSF14
HGNC
Name
TNF superfamily member 14
HGNC
NCBI Gene ID
8740
NCBI Gene
HGNC ID
HGNC:11930
HGNC
Ensembl
ENSG00000125735
NCBI Gene
Aliases
CD258, HVEM-L, HVEML, LIGHT, LTg
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43557Tumor necrosis factor ligand superfamily member 142407Ensembl, GeneID, HGNC

Source UniProt

Patents273

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026086743 A2026-05-26180O43557Espacenet
JP 2026062687 A2026-04-10443O43557Espacenet
WO 2026019692 A22026-01-2211O43557Espacenet
JP 2026004568 A2026-01-1468629O43557Espacenet
JP 2026004568 A2026-01-1468637O43557Espacenet
JP 2026500896 A2026-01-0921O43557Espacenet
JP 2026000906 A2026-01-0641O43557Espacenet
WO 2025262304 A12025-12-2628O43557Espacenet
WO 2025235604 A12025-11-1321O43557Espacenet
WO 2025235605 A12025-11-1321O43557Espacenet

1 to 10 of 273

See all 273 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BAMINERCEPTCHEMBL1742988Tumor necrosis factor ligand superfamily member 14 inhibitorINHIBITORChEMBL
QUISOVALIMABCHEMBL4802198Tumor necrosis factor ligand superfamily member 14 inhibitorINHIBITORChEMBL

Trials11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05288504QUISOVALIMABPHASE22024-09-05ClinicalTrials.gov
NCT04412057QUISOVALIMABPHASE22022-03-04ClinicalTrials.gov
NCT03169894QUISOVALIMABPHASE12024-02-26ClinicalTrials.gov
NCT01552681BAMINERCEPTPHASE22016-03-23ClinicalTrials.gov
NCT01181089BAMINERCEPTPHASE1/PHASE2ClinicalTrials.gov
NCT01164384BAMINERCEPTPHASE1ClinicalTrials.gov
NCT00664716BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00664573BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00523328BAMINERCEPTPHASE2ClinicalTrials.gov
NCT00458861BAMINERCEPTPHASE2ClinicalTrials.gov

1 to 10 of 11

See all 11 trials

NIH grants1,085

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFSF14 papersNewest fiscal year
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma112025
P30CA008748Cancer Center Support Grant42025
R01DK114457TWEAK/TNFSF12 and LIGHT/TNFSF14 interactions in allergic esophagitis remodeling42025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro42025
U19AI167903Systems biological assessment of innate and adaptive immunity to vaccination42025
P30CA006973Regional Oncology Research Center32025
P30CA013330Cancer Center Support Grant32025
P30CA047904Cancer Center Support Grant32025
P42ES004705Toxic substances in the environment32025
R37CA238435Stimulating Lymphocyte Activation Combined with Inhibition of Immunosuppressive Signals in Colon Cancer Metastases32025

1 to 10 of 1,085Source NIH's project files

See all 1,085 nih grants

Papers1,880

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mutant HVEM in lymphoma disrupts BTLA and CD160 regulation of anti-tumor signaling.Front Immunol202642798506PubTator, text miningPubMed
Cerebrospinal fluid protein elevations in Alzheimer's disease are dissociated from immune cell composition.Alzheimers Dement (N Y)202642787519PubTator, text miningPubMed
The plasma protein profile of left ventricular diastolic function.Sci Rep202642680832PubTator, text miningPubMed
Impact of Gestational Maternal SARS-CoV-2 Infection on Neonatal Inflammatory Biomarkers.Am J Reprod Immunol202642640037PubTator, text miningPubMed
Subclinical inflammation associated with monosodium urate crystal deposition: a cellular and proteomic study in synovial fluid.Front Immunol202642625747PubTator, text miningPubMed
Beyond type 2 inflammation: An innate-myeloid axis is linked to recurrence of chronic rhinosinusitis with nasal polyps.J Allergy Clin Immunol202642567484PubTator, text miningPubMed
Community-Acquired Pneumonia: Disease Course Prediction With a 5-Gene Signature.CHEST Pulm202642548383PubTator, text miningPubMed
TNFSF14/LIGHT responses in intestinal and oesophageal fibroblasts are differentially modulated by hydroxylase inhibitors.J Physiol202642516061PubTator, text miningPubMed
Multi-omics Insights Into the Effect of Feeding Yeast Culture on the Liver Metabolism and Immunity of Plectropomus leopardus.Aquac Nutr202642491538PubTator, text miningPubMed
Machine learning-based analysis of oral rinse samples to identify candidate proteomic signatures for severe periodontitis: a pilot study.Sci Rep202642448777PubTator, text miningPubMed

1 to 10 of 1,880

See all 1,880 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8740

GET https://conductscience.org/api/genes/v1/8740/patents?page=2