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Gene · 8741

TNFSF13: TNF superfamily member 13

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNFSF13: TNF superfamily member 13. Genes, record 8741. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8741

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Gene

Symbol
TNFSF13
HGNC
Name
TNF superfamily member 13
HGNC
NCBI Gene ID
8741
NCBI Gene
HGNC ID
HGNC:11928
HGNC
Ensembl
ENSG00000161955
NCBI Gene
Aliases
APRIL, CD256, TALL-2, TALL2, TNLG7B, TRDL-1, UNQ383/PRO715, ZTNF2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O75888Tumor necrosis factor ligand superfamily member 132501Ensembl, GeneID, HGNC

Source UniProt

Patents290

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026094457 A2026-06-0985O75888Espacenet
EP 4650780 A22025-11-196815O75888Espacenet
EP 4640849 A22025-10-29985O75888Espacenet
EP 4641201 A22025-10-296617O75888Espacenet
JP 2025147176 A2025-10-0616618O75888Espacenet
JP 2025138725 A2025-09-252211O75888Espacenet
JP 2025519096 A2025-06-24985O75888Espacenet
JP 2025517969 A2025-06-126617O75888Espacenet
JP 2025517970 A2025-06-126815O75888Espacenet
JP 2025514142 A2025-05-0285O75888Espacenet

1 to 10 of 290

See all 290 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ATACICEPTCHEMBL1742986Tumor necrosis factor ligand superfamily member 13 inhibitorINHIBITORChEMBL
SIBEPRENLIMABCHEMBL4594614Tumor necrosis factor ligand superfamily member 13 inhibitorINHIBITORChEMBL

Trials23

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07020923ATACICEPTPHASE2ClinicalTrials.gov
NCT06983028ATACICEPTPHASE2ClinicalTrials.gov
NCT06928142SIBEPRENLIMABPHASE2ClinicalTrials.gov
NCT06740526SIBEPRENLIMABPHASE2ClinicalTrials.gov
NCT06674577ATACICEPTPHASE2ClinicalTrials.gov
NCT05609812ATACICEPTPHASE3ClinicalTrials.gov
NCT05248659SIBEPRENLIMABPHASE2/PHASE3ClinicalTrials.gov
NCT05248646SIBEPRENLIMABPHASE3ClinicalTrials.gov
NCT04716231ATACICEPTPHASE3ClinicalTrials.gov
NCT04287985SIBEPRENLIMABPHASE22024-11-21ClinicalTrials.gov

1 to 10 of 23

See all 23 trials

NIH grants753

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFSF13 papersNewest fiscal year
P30CA016672Cancer Center Support Grant42025
R01DK078244Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes42025
P01CA155258Integrative Oncogenomics of Multiple Myeloma32025
P30CA008748Cancer Center Support Grant32025
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease32025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged32025
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma32025
UL1TR001863Yale Clinical and Translational Science Award32025
P30AI050410The University of North Carolina Center for AIDS Research22025
P30CA016056Roswell Park Cancer Center Support Grant22025

1 to 10 of 753Source NIH's project files

See all 753 nih grants

Papers1,439

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Atacicept: First Approval.Drugs202642714746PubTator, text miningPubMed
Atacicept in IgA nephropathy.Expert Rev Clin Immunol202642710874PubTator, text miningPubMed
TNFSF13 Drives Atherosclerosis Progression by Targeting Macrophage Senescence.Int J Med Sci202642694578PubTator, text miningPubMed
Humoral Response to COVID-19 Vaccines and Infection during Sibeprenlimab Treatment of IgA Nephropathy: Data from the ENVISION Trial.Clin J Am Soc Nephrol202642275148PubTator, text miningPubMed
Association between TNFSF13 SNPs and progression to end-stage renal disease in IgA nephropathy patients.Int Urol Nephrol202642262683PubTator, text miningPubMed
Zigakibart Potently Inhibits A Proliferation-Inducing Ligand-Mediated IgA Production, Addressing IgAN Pathogenesis Root Causes.Kidney Int Rep202642205925PubTator, text miningPubMed
Inflammatory Biomarkers Are Associated with Pain and Functional Impairment in Knee Osteoarthritis Patients: A Cross-Sectional Pilot Study.J Clin Med202642123198PubTator, text miningPubMed
Efficacy, safety, and biomarker changes of B-cell activating factor and A proliferation-inducing ligand-targeted therapies in IgA nephropathy: a systematic review and meta-analysis of randomized controlled trials.
J Nephrol202642014363PubTator, text miningPubMed
TNFSF13 insufficiency disrupts human colonic epithelial cell growth and associated B cell dynamics.J Clin Invest202641919502PubTator, text miningPubMed
Prediction of depressive episodes based on clinical features, cognitive characteristics, inflammation-related proteins, and EEG data.Transl Psychiatry202641876463PubTator, text miningPubMed

1 to 10 of 1,439

See all 1,439 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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