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Gene · 8744

TNFSF9: TNF superfamily member 9

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. TNFSF9: TNF superfamily member 9. Genes, record 8744. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8744

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Gene

Symbol
TNFSF9
HGNC
Name
TNF superfamily member 9
HGNC
NCBI Gene ID
8744
NCBI Gene
HGNC ID
HGNC:11939
HGNC
Ensembl
ENSG00000125657
NCBI Gene
Aliases
4-1BB-L, 4-1BBL, CD137L, TNLG5A
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41273Tumor necrosis factor ligand superfamily member 92549Ensembl, GeneID, HGNC

Source UniProt

Patents666

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026183237 A12026-09-0377P41273Espacenet
EP 4758171 A12026-06-1749P41273Espacenet
US 12655389 B22026-06-1646P41273Espacenet
US 12655391 B22026-06-161P41273Espacenet
JP 2026089698 A2026-06-0157P41273Espacenet
JP 2026086743 A2026-05-26168P41273Espacenet
JP 2026077646 A2026-05-1346P41273Espacenet
EP 4725503 A22026-04-152627P41273Espacenet
JP 2026062687 A2026-04-1046P41273Espacenet
EP 4705273 A22026-03-11333P41273Espacenet

1 to 10 of 666

See all 666 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,618

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleTNFSF9 papersNewest fiscal year
P30CA016672Cancer Center Support Grant532025
P30CA008748Cancer Center Support Grant292025
P50CA126752SPORE in Lymphoma192025
P30CA021765Cancer Center Support Grant (CCSG)132025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant132025
T32HL092332Training In Cell and Gene Therapy122025
P01CA065493Off-the-Shelf Immune Effector Cells for Hematological Malignancies92025
P01CA111412NK cells, their receptors and cancer therapy92025
P30CA006973Regional Oncology Research Center62025
P30CA076292Moffitt Cancer Center Support Grant62025

1 to 10 of 1,618Source NIH's project files

See all 1,618 nih grants

Papers3,166

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Network of interactions between the tumor necrosis factor superfamily members and small S100 proteins.PLoS One202642809589PubTator, text miningPubMed
Cord Blood-Derived Fibroblast Activation Protein-Targeted Chimeric Antigen Receptor Natural Killer Cells Persist in Vivo.Cancer Sci202642764195PubTator, text miningPubMed
Oncogenic Mutations and Tumor Microenvironment Alterations in Diffuse Large B-Cell Lymphoma With Bulky Disease.Cancer Med202642702822PubTator, text miningPubMed
Single-cell multiomics reveals exosome-mediated reprogramming and clonotypic remodeling of T cells in triple-negative breast cancer.Signal Transduct Target Ther202642618562PubTator, text miningPubMed
A PD1-CD137L Fusion Protein More Potently Enhances Anti-Tumour Immune Responses Than Targeting PD-L1 and CD137 Separately.Immunology202642572505PubTator, text miningPubMed
Dual stimulation of CD40 and 41BB pathways during ex-vivo TIL expansion enhances CD8+ T cell expansion.bioRxiv202642538952PubTator, text miningPubMed
Assessment of the Novel rVSV-PD-1-4-1BBL Oncolytic Activity on Mouse and Human Cancer Cell Lines.Biomedicines202642511949PubTator, text miningPubMed
4-1BBL Suppresses Anti-Inflammatory Responses by Regulating Metabolic Reprogramming of Macrophages.Immunology202642504467PubTator, text miningPubMed
Englumafusp alfa plus glofitamab in B cell non-Hodgkin lymphoma: a phase 1 trial.Nat Med202642463852PubTator, text miningPubMed
CD137 in cancer therapy - bench to bedside.Immunotherapy202642427082PubTator, text miningPubMed

1 to 10 of 3,166

See all 3,166 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8744

GET https://conductscience.org/api/genes/v1/8744/patents?page=2