ConductScience.org, home

Gene · 8767

RIPK2: receptor interacting serine/threonine kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. RIPK2: receptor interacting serine/threonine kinase 2. Genes, record 8767. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8767

On this page

Gene

Symbol
RIPK2
HGNC
Name
receptor interacting serine/threonine kinase 2
HGNC
NCBI Gene ID
8767
NCBI Gene
HGNC ID
HGNC:10020
HGNC
Ensembl
ENSG00000104312
NCBI Gene
Aliases
CARD3, CARDIAK, CCK, GIG30, RICK, RIP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43353Receptor-interacting serine/threonine-protein kinase 254033Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4724437 A12026-04-151O43353Espacenet
EP 4724440 A12026-04-151O43353Espacenet
EP 4650780 A22025-11-19479O43353Espacenet
EP 4641202 A22025-10-294332O43353Espacenet
JP 2025517970 A2025-06-12479O43353Espacenet
KR 1020250017231 A2025-02-044332O43353Espacenet
JP 2024534853 A2024-09-26101O43353Espacenet
JP 2024123008 A2024-09-108144O43353Espacenet
US 11446398 B22022-09-2072115O43353Espacenet
JP 2022524081 A2022-04-27175086O43353Espacenet

1 to 10 of 56

See all 56 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,634

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleRIPK2 papersNewest fiscal year
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital102025
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities82025
ZIAAI000354Immunoregulatory Defects In Inflammatory Bowel Disease72025
P30DK034989Yale Liver Center62025
R01DK099097Functional outcomes of inflammatory bowel disease associated variants62025
U01DK062422Mount Sinai NYC Genetics Research Center: Multi-omic integration across data-types, cell niches and populations62025
UL1TR001863Yale Clinical and Translational Science Award62025
ZIAAI000432Regulation Of Immune Responses In Humans and in Experimental Animals62025
P30DK034854Integrated Epithelial and Muscosal Biology52025
R01GM086858New Molecular Probes For Protein Kinases52025

1 to 10 of 1,634Source NIH's project files

See all 1,634 nih grants

Papers2,573

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Elevated RIPK2 Expression in Atopic Dermatitis Skin Is Associated with Mixed Th1/Th2 Cytokine Responses in CD4+ T Cells.Int J Mol Sci202642794681PubTator, text miningPubMed
Multi-omics characterization of Yao syndrome identifies three pathophysiological axes and disease-specific divergence from Blau syndrome.Inflamm Res202642786248PubTator, text miningPubMed
Targeting intracellular immune regulatory molecules for cancer immunotherapy in solid tumors.Crit Rev Oncol Hematol202642732787PubTator, text miningPubMed
Identification of Cellular Senescence-Related Hub Genes in Rheumatoid Arthritis from Bioinformatics Analysis Through Machine Learning up to Verifications in Mouse Macrophages and Tests in Patients.Int J Mol Sci202642653491PubTator, text miningPubMed
A network toxicology and machine learning approach to uncover the molecular machinery of bisphenol A-induced colorectal cancer.Sci Rep202642624872PubTator, text miningPubMed
EBER-associated promoter contacts mark accessible but transcriptionally constrained RNAPII promoter hubs in EBV-positive B cells.Epigenetics Chromatin202642477823PubTator, text miningPubMed
NOD1/2 signaling in macrophages drives adaptive immune resistance in cancer.Signal Transduct Target Ther202642476973PubTator, text miningPubMed
The dual role of RIPK family in IBD: from cell death to therapeutic targeting.Mol Med202642469615PubTator, text miningPubMed
CSN3 promotes gastric cancer progression and is associated with immune infiltration and inflammatory signaling.Transl Cancer Res202642445438PubTator, text miningPubMed
Platelet RIP2 Limits Dense Granule Release and Thrombosis via DOCK8-Cdc42.Arterioscler Thromb Vasc Biol202642273729PubTator, text miningPubMed

1 to 10 of 2,573

See all 2,573 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8767

GET https://conductscience.org/api/genes/v1/8767/patents?page=2