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Gene · 8784

TNFRSF18: TNF receptor superfamily member 18

11 sourcesgene-search-2026-11-11-0.1.0

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ConductScience Library. TNFRSF18: TNF receptor superfamily member 18. Genes, record 8784. Release gene-search-2026-11-11-0.1.0, 11 Nov 2026. https://conductscience.org/library/genes/8784

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Gene

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

Symbol
TNFRSF18
HGNC
Name
TNF receptor superfamily member 18
HGNC
NCBI Gene ID
8784
NCBI Gene
HGNC ID
HGNC:11914
HGNC
Ensembl
ENSG00000186891
NCBI Gene
Aliases
AITR, CD357, ENERGEN, GITR, GITR-D
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9Y5U5Tumor necrosis factor receptor superfamily member 182413Ensembl, GeneID, HGNC

Source UniProt

Patents283

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062687 A2026-04-10142Q9Y5U5Espacenet
JP 2026004568 A2026-01-1468670Q9Y5U5Espacenet
JP 2025172069 A2025-11-20693Q9Y5U5Espacenet
EP 4650780 A22025-11-1910137Q9Y5U5Espacenet
EP 4641202 A22025-10-29579Q9Y5U5Espacenet
EP 4641203 A22025-10-29300Q9Y5U5Espacenet
JP 2025147176 A2025-10-0613579Q9Y5U5Espacenet
JP 2025147176 A2025-10-0614708Q9Y5U5Espacenet
JP 2025147176 A2025-10-0616722Q9Y5U5Espacenet
EP 4619424 A22025-09-24108Q9Y5U5Espacenet

1 to 10 of 283

See all 283 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
RAGIFILIMABCHEMBL4594558Tumor necrosis factor receptor superfamily member 18 agonistAGONISTChEMBL
TRX-518CHEMBL2109428Tumor necrosis factor receptor superfamily member 18 agonistAGONISTChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05359692RAGIFILIMABPHASE2ClinicalTrials.gov
NCT04470024RAGIFILIMABPHASE1ClinicalTrials.gov
NCT04225039RAGIFILIMABPHASE22023-09-15ClinicalTrials.gov
NCT03277352RAGIFILIMABPHASE1/PHASE22021-07-22ClinicalTrials.gov
NCT03126110RAGIFILIMABPHASE1/PHASE22022-12-28ClinicalTrials.gov
NCT03088059RAGIFILIMABPHASE2ClinicalTrials.gov
NCT01239134TRX-518PHASE1ClinicalTrials.gov

NIH grants2,580

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal year
P30CA008748Cancer Center Support Grant662025
P30CA016672Cancer Center Support Grant352025
P30CA006973Regional Oncology Research Center132025
P30CA047904Cancer Center Support Grant132025
P30CA086862Cancer Center Support Grant122025
P01AI039671Costimulatory Mechanisms of Autoimmunity92025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital92025
UL1TR001863Yale Clinical and Translational Science Award92025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center82025
P01CA155258Integrative Oncogenomics of Multiple Myeloma72025

1 to 10 of 2,580Source NIH's project files

See all 2,580 nih grants

Papers4,557

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42776797PubTator, text miningPubMed
42724996PubTator, text miningPubMed
42687902PubTator, text miningPubMed
42634197PubTator, text miningPubMed
42562176PubTator, text miningPubMed
42557403PubTator, text miningPubMed
42530885PubTator, text miningPubMed
42488650PubTator, text miningPubMed
42483409PubTator, text miningPubMed
42416065PubTator, text miningPubMed

1 to 10 of 4,557

See all 4,557 papers

Sources 11

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNone stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GeneNone named. Public domain as US government information
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8784

GET https://conductscience.org/api/genes/v1/8784/patents?page=2