ConductScience.org, home

Gene · 8788

DLK1: delta like non-canonical Notch ligand 1

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. DLK1: delta like non-canonical Notch ligand 1. Genes, record 8788. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8788

On this page

Gene

Symbol
DLK1
HGNC
Name
delta like non-canonical Notch ligand 1
HGNC
NCBI Gene ID
8788
NCBI Gene
HGNC ID
HGNC:2907
HGNC
Ensembl
ENSG00000185559
NCBI Gene
Aliases
DLK, DLK-1, Delta1, FA1, PREF1, Pref-1, ZOG, pG2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P80370Protein delta homolog 13831Ensembl, GeneID, HGNC

Source UniProt

Patents52

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1443561P80370Espacenet
EP 4650780 A22025-11-196523P80370Espacenet
EP 4640849 A22025-10-29935P80370Espacenet
EP 4641201 A22025-10-296269P80370Espacenet
JP 2025147176 A2025-10-064276P80370Espacenet
JP 2025529142 A2025-09-041271P80370Espacenet
JP 2025529142 A2025-09-046187P80370Espacenet
US 12371689 B22025-07-291271P80370Espacenet
US 12371689 B22025-07-296187P80370Espacenet
JP 2025519096 A2025-06-24935P80370Espacenet

1 to 10 of 52

See all 52 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,540

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDLK1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)142025
R01HD082314Deciphering the functional role of MKRN3 in puberty and reproduction122025
P30CA008748Cancer Center Support Grant112025
P40OD010440Caenorhabditis Genetics Center102025
P30ES025128Center for Human Health and the Environment (CHHE)92025
P30DK036836Diabetes Research Center72025
P30DK026743UCSF Liver Center62025
P20GM121301Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks52025
P30CA015704Cancer Center Support Grant52025

1 to 10 of 2,540Source NIH's project files

See all 2,540 nih grants

Papers3,998

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus?Int J Mol Sci202642794587PubTator, text miningPubMed
Interindividual variability of sperm DNA methylation is associated with reduced fecundability in couples attempting natural conception.Hum Reprod202642786259PubTator, text miningPubMed
Transcriptomic and miRNA-Target Pathway Analysis of the DLK1-DIO3 Imprinted microRNA Cluster in Chronic Lymphocytic Leukemia.Diseases202642783213PubTator, text miningPubMed
A methanogen hydrolase reveals the structure of archaeal peptidoglycan.Nature202642778595PubTator, text miningPubMed
Delayed late ventricular depolarization is associated with inflammation in epicardial Fat Among females: a New avenue in cardiac electrophysiology.Front Cardiovasc Med202642769221PubTator, text miningPubMed
High-Throughput Characterization of Human Fibroblast Responses to a Panel of Staphylococcus aureus Antigen Proteins Using Olink Proteomics.Open Forum Infect Dis202642751267PubTator, text miningPubMed
Syndrome differentiation and treatment of pediatric central precocious puberty: role of the spleen-kidney axis.Front Immunol202642713456PubTator, text miningPubMed
Reciprocal, methylation-dependent binding of Zfp57 and Gzf1 safeguards Dlk1-Dio3 imprinting during developmental reprogramming.Nat Commun202642686776PubTator, text miningPubMed
Establishment of a ZFP64::NCOA3 fusion-positive spindle cell/sclerosing rhabdomyosarcoma organoid model and evaluation of fusion-gene dependency.Hum Cell202642622717PubTator, text miningPubMed
Senescent microglia with shortened telomeres secrete soluble DLK1 to induce aging-associated hypomyelination and neuronal dysfunction.Neuron202642580340PubTator, text miningPubMed

1 to 10 of 3,998

See all 3,998 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8788

GET https://conductscience.org/api/genes/v1/8788/patents?page=2