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TNFRSF10B: TNF receptor superfamily member 10b

1 protein, 105 patents, 7 drugs, 30 trials, 4,223 NIH grants and 10,705 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFRSF10BHGNC
NameTNF receptor superfamily member 10bHGNC
NCBI Gene ID8795NCBI Gene
HGNC IDHGNC:11905HGNC
EnsemblENSG00000120889NCBI Gene
AliasesCD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14763Tumor necrosis factor receptor superfamily member 10B44013Ensembl, GeneID, HGNCUniProt

Patents 105

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4731188 A22026-04-294O14763Espacenet
JP 2026505888 A2026-02-1995O14763Espacenet
EP 4653468 A12025-11-2695O14763Espacenet
EP 4650780 A22025-11-192969O14763Espacenet
EP 4640849 A22025-10-29368O14763Espacenet
EP 4641201 A22025-10-292541O14763Espacenet
JP 2025147176 A2025-10-0616515O14763Espacenet
JP 2025147176 A2025-10-0616791O14763Espacenet
KR 1020250134237 A2025-09-1095O14763Espacenet
JP 2025529142 A2025-09-044996O14763Espacenet

Drugs 7

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APOMABCHEMBL2109248Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL
CONATUMUMABCHEMBL1743003Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL
DROZITUMABCHEMBL1743008Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL
DULANERMINCHEMBL2107846Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL
LBY-135CHEMBL2109247Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL
LEXATUMUMABCHEMBL1743036Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL
TIGATUZUMABCHEMBL1743080Tumor necrosis factor receptor superfamily member 10B agonistAGONISTChEMBL

Trials 30

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01940172CONATUMUMABPHASE1ClinicalTrials.gov
NCT01307891TIGATUZUMABPHASE22017-09-13ClinicalTrials.gov
NCT01220999TIGATUZUMABPHASE12019-09-23ClinicalTrials.gov
NCT01124630TIGATUZUMABPHASE1ClinicalTrials.gov
NCT01033240TIGATUZUMABPHASE22021-04-08ClinicalTrials.gov
NCT01017822CONATUMUMABPHASE1/PHASE2ClinicalTrials.gov
NCT00991796TIGATUZUMABPHASE2ClinicalTrials.gov
NCT00969033TIGATUZUMABPHASE2ClinicalTrials.gov
NCT00945191TIGATUZUMABPHASE22020-11-18ClinicalTrials.gov
NCT00873756DULANERMINPHASE1ClinicalTrials.gov

NIH grants 4223

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant692,025NIH's project files
P30CA047904Cancer Center Support Grant312,025NIH's project files
P30CA008748Cancer Center Support Grant232,025NIH's project files
P30CA013148Comprehensive Cancer Center Support Grant192,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology172,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant162,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase142,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)142,025NIH's project files
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)132,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant122,025NIH's project files

Papers 10705

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42816446PubTator, text miningPubMed
42794810PubTator, text miningPubMed
42757818PubTator, text miningPubMed
42751267PubTator, text miningPubMed
42738906PubTator, text miningPubMed
42737771PubTator, text miningPubMed
42692375PubTator, text miningPubMed
42690005PubTator, text miningPubMed
42674237PubTator, text miningPubMed
42653075PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license