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TNFRSF10A: TNF receptor superfamily member 10a

1 protein, 80 patents, 2 drugs, 11 trials, 2,196 NIH grants and 5,209 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTNFRSF10AHGNC
NameTNF receptor superfamily member 10aHGNC
NCBI Gene ID8797NCBI Gene
HGNC IDHGNC:11904HGNC
EnsemblENSG00000104689NCBI Gene
AliasesAPO2, Apo2, CD261, DR4, TRAILR-1, TRAILR1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O00220Tumor necrosis factor receptor superfamily member 10A4681Ensembl, GeneID, HGNCUniProt

Patents 80

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4731188 A22026-04-293O00220Espacenet
EP 4661970 A12025-12-1762171O00220Espacenet
JP 2025147176 A2025-10-0616514O00220Espacenet
JP 2025147176 A2025-10-0616790O00220Espacenet
JP 2025530208 A2025-09-1168O00220Espacenet
JP 2025529142 A2025-09-044995O00220Espacenet
US 12392775 B22025-08-1910O00220Espacenet
US 12392775 B22025-08-199O00220Espacenet
US 12371689 B22025-07-294995O00220Espacenet
US 12351650 B22025-07-0868O00220Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DULANERMINCHEMBL2107846TRAIL receptor-1 agonistAGONISTChEMBL
MAPATUMUMABCHEMBL2108621TRAIL receptor-1 agonistAGONISTChEMBL

Trials 11

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01258608MAPATUMUMABPHASE1/PHASE22018-12-19ClinicalTrials.gov
NCT01088347MAPATUMUMABPHASE1/PHASE2ClinicalTrials.gov
NCT00873756DULANERMINPHASE1ClinicalTrials.gov
NCT00712855MAPATUMUMABPHASE1ClinicalTrials.gov
NCT00671372DULANERMINPHASE1ClinicalTrials.gov
NCT00583830MAPATUMUMABPHASE2ClinicalTrials.gov
NCT00508625DULANERMINPHASE2ClinicalTrials.gov
NCT00400764DULANERMINPHASE1/PHASE22011-10-07ClinicalTrials.gov
NCT00315757MAPATUMUMABPHASE2ClinicalTrials.gov
NCT00094848MAPATUMUMABPHASE2ClinicalTrials.gov

NIH grants 2196

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant292,025NIH's project files
P30CA047904Cancer Center Support Grant172,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant92,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology92,025NIH's project files
ZIASC007263Activating Cell Death Pathways in Breast Cancer Cells92,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)82,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan82,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase72,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant72,025NIH's project files

Papers 5209

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42803969PubTator, text miningPubMed
42721850PubTator, text miningPubMed
42718750PubTator, text miningPubMed
42653075PubTator, text miningPubMed
42598821PubTator, text miningPubMed
42393365PubTator, text miningPubMed
42376204PubTator, text miningPubMed
42324555PubTator, text miningPubMed
42265127PubTator, text miningPubMed
42238393PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license