Gene · 8798
DYRK4: dual specificity tyrosine phosphorylation regulated kinase 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. DYRK4: dual specificity tyrosine phosphorylation regulated kinase 4. Genes, record 8798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8798
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9NR20 | Dual specificity tyrosine-phosphorylation-regulated kinase 4 | 520 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents37
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 44367 | Q9NR20 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 44368 | Q9NR20 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 28 | Q9NR20 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 28 | Q9NR20 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27574 | Q9NR20 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 27576 | Q9NR20 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 27574 | Q9NR20 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 27576 | Q9NR20 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 27574 | Q9NR20 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 27576 | Q9NR20 | Espacenet |
1 to 10 of 37
See all 37 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants150
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | DYRK4 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 3 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 2 | 2025 |
| P20GM103434 | West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE) | 1 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 1 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 1 | 2025 |
| P30CA240139 | The Sylvester Cancer Center Support Grant | 1 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 1 | 2025 |
| P30DK036836 | Diabetes Research Center | 1 | 2025 |
| P30ES007048 | Environmental Exposures, Host Factors and Human Disease | 1 | 2025 |
| P50CA159981 | Roswell Park Ovarian Cancer SPORE | 1 | 2025 |
1 to 10 of 150Source NIH's project files
See all 150 nih grantsPapers160
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| DYRK kinases phosphorylate IL-17RA at S801. | Serican J Med | 2026 | 42746556 | PubTator, text mining | PubMed |
| Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies. | Cell Oncol (Dordr) | 2026 | 41636961 | PubTator, text mining | PubMed |
| Unveiling the biophysical basis of DYRK kinase family isoform selectivity mechanism of Abemaciclib using computational approaches. | SAR QSAR Environ Res | 2025 | 40904174 | PubTator, text mining | PubMed |
| Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy. | Int J Biol Sci | 2025 | 40303300 | PubTator, text mining | PubMed |
| DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation. | EMBO Rep | 2025 | 39702801 | PubTator, text mining | PubMed |
| Illuminating the druggable genome: Pathways to progress. | Drug Discov Today | 2024 | 37890715 | PubTator, text mining | PubMed |
| PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma. | Int J Mol Sci | 2023 | 38139175 | PubTator, text mining | PubMed |
| Host kinase regulation of Plasmodium vivax dormant and replicating liver stages. | bioRxiv | 2023 | 38014051 | PubTator, text mining | PubMed |
| Regulation of CMGC kinases by hypoxia. | BMB Rep | 2023 | 37915135 | PubTator, text mining | PubMed |
| Insights from the protein interaction Universe of the multifunctional "Goldilocks" kinase DYRK1A. | Front Cell Dev Biol | 2023 | 37900285 | PubTator, text mining | PubMed |
1 to 10 of 160
See all 160 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8798
GET https://conductscience.org/api/genes/v1/8798/patents?page=2