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Gene · 8798

DYRK4: dual specificity tyrosine phosphorylation regulated kinase 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. DYRK4: dual specificity tyrosine phosphorylation regulated kinase 4. Genes, record 8798. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8798

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Gene

Symbol
DYRK4
HGNC
Name
dual specificity tyrosine phosphorylation regulated kinase 4
HGNC
NCBI Gene ID
8798
NCBI Gene
HGNC ID
HGNC:3095
HGNC
Ensembl
ENSG00000010219
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9NR20Dual specificity tyrosine-phosphorylation-regulated kinase 45200Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1444367Q9NR20Espacenet
JP 2026004568 A2026-01-1444368Q9NR20Espacenet
EP 4641201 A22025-10-2928Q9NR20Espacenet
JP 2025517969 A2025-06-1228Q9NR20Espacenet
JP 2025032204 A2025-03-1127574Q9NR20Espacenet
JP 2025032204 A2025-03-1127576Q9NR20Espacenet
EP 4461818 A22024-11-1327574Q9NR20Espacenet
EP 4461818 A22024-11-1327576Q9NR20Espacenet
JP 2023058610 A2023-04-2527574Q9NR20Espacenet
JP 2023058610 A2023-04-2527576Q9NR20Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants150

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleDYRK4 papersNewest fiscal year
P30DK020541NYR-Diabetes Research Center (NYR-DRC)32025
P30CA047904Cancer Center Support Grant22025
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)12025
P30CA013148Comprehensive Cancer Center Support Grant12025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant12025
P30CA240139The Sylvester Cancer Center Support Grant12025
P30DK020593Vanderbilt Diabetes Research Center12025
P30DK036836Diabetes Research Center12025
P30ES007048Environmental Exposures, Host Factors and Human Disease12025
P50CA159981Roswell Park Ovarian Cancer SPORE12025

1 to 10 of 150Source NIH's project files

See all 150 nih grants

Papers160

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
DYRK kinases phosphorylate IL-17RA at S801.Serican J Med202642746556PubTator, text miningPubMed
Decoding SR protein regulation: kinases, phosphatases, and therapeutic targeting strategies.Cell Oncol (Dordr)202641636961PubTator, text miningPubMed
Unveiling the biophysical basis of DYRK kinase family isoform selectivity mechanism of Abemaciclib using computational approaches.SAR QSAR Environ Res202540904174PubTator, text miningPubMed
Dual-specificity tyrosine-regulated kinase 4 modulates the STAT3-FOS signaling axis to inhibit hepatitis B virus replication via autophagy.Int J Biol Sci202540303300PubTator, text miningPubMed
DYRK4 upregulates antiviral innate immunity by promoting IRF3 activation.EMBO Rep202539702801PubTator, text miningPubMed
Illuminating the druggable genome: Pathways to progress.Drug Discov Today202437890715PubTator, text miningPubMed
PAICS/DYRK3 Multienzyme Interactions as Coregulators of Purinosome Formation and Metabolism on Radioresistance in Oral Squamous Cell Carcinoma.Int J Mol Sci202338139175PubTator, text miningPubMed
Host kinase regulation of Plasmodium vivax dormant and replicating liver stages.bioRxiv202338014051PubTator, text miningPubMed
Regulation of CMGC kinases by hypoxia.BMB Rep202337915135PubTator, text miningPubMed
Insights from the protein interaction Universe of the multifunctional "Goldilocks" kinase DYRK1A.Front Cell Dev Biol202337900285PubTator, text miningPubMed

1 to 10 of 160

See all 160 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8798

GET https://conductscience.org/api/genes/v1/8798/patents?page=2