Gene · 88
ACTN2: actinin alpha 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACTN2: actinin alpha 2. Genes, record 88. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/88
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P35609 | Alpha-actinin-2 | 894 | 16 | Ensembl, GeneID, HGNC |
Source UniProt
Patents36
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 36119 | P35609 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8214 | P35609 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8214 | P35609 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1532 | P35609 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24024 | P35609 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24024 | P35609 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 24024 | P35609 | Espacenet |
| JP 2023516705 A | 2023-04-20 | 62 | P35609 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 1532 | P35609 | Espacenet |
| JP 2022525703 A | 2022-05-18 | 101 | P35609 | Espacenet |
1 to 10 of 36
See all 36 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,324
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACTN2 papers | Newest fiscal year |
|---|---|---|---|
| R01HL085844 | Functional interactions of cardiac ion channels | 9 | 2025 |
| R35GM125028 | The assembly and function of cellular contractile systems | 8 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 5 | 2025 |
| T32HL086350 | Training Program in Basic and Translational Cardiovascular Science | 5 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| P30DK017047 | Diabetes Research Center | 4 | 2025 |
| R01HL132401 | Mechanisms and Therapeutic Targeting of DNA Damage in Dilated Cardiomyopathy Caused by LMNA Mutations | 4 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 3 | 2025 |
| P30EY008126 | Core Grant in Vision Research | 3 | 2025 |
| T32EB009035 | Multi-Disciplinary Training Program in Cardiovascular Imaging at Stanford | 3 | 2025 |
1 to 10 of 1,324Source NIH's project files
See all 1,324 nih grantsPapers1,598
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Extended genotype-phenotype spectrum of 17α-hydroxylase/17,20-lyase deficiency: a nine-case series featuring a novel mutation, suspected TART-like lesions, and multisystem involvement. | Front Endocrinol (Lausanne) | 2026 | 42824042 | PubTator, text mining | PubMed |
| Using iPALM to determine protein organisation in cardiac muscle Z-discs. | PLoS Comput Biol | 2026 | 42804542 | PubTator, text mining | PubMed |
| Integrative Multi-Omics Analysis Identifies Thrombosis-Associated Molecular Features Linked to Germline Susceptibility and Immune Cell Communication in Gastric Cancer. | Chem Biol Drug Des | 2026 | 42681916 | PubTator, text mining | PubMed |
| Multispecies Transcriptomics of Mammalian Skin Reveals Conserved and Divergent Regulatory Features. | Int J Mol Sci | 2026 | 42653506 | PubTator, text mining | PubMed |
| Comprehensive biophysical and structural profiling of alpha-actinin-2 variants reveals mechanistic diversity in hypertrophic cardiomyopathy. | Nat Commun | 2026 | 42481460 | PubTator, text mining | PubMed |
| Regulation of NMDA receptor interactions with the actin cytoskeleton in dendritic spine development. | Front Cell Neurosci | 2026 | 42290955 | PubTator, text mining | PubMed |
| Post-infarction KLHL40-mediated regulation of cardiac sarcomeric integrity and function. | PeerJ | 2026 | 42267082 | PubTator, text mining | PubMed |
| Coaxially Electrospun Myocardial dECM- Based Nanofibrous Scaffolds Demonstrate Enhanced Cardiomyocyte Biocompatibility. | Adv Healthc Mater | 2026 | 42152235 | PubTator, text mining | PubMed |
| Magnetic torque-mediated early asymmetric mechanical stimulation directs structural and functional maturation in human cardiac organoids. | Sci Rep | 2026 | 42115257 | PubTator, text mining | PubMed |
| Biological properties of α-actinin-2 and its role and mechanisms in disease development. | Front Physiol | 2026 | 42111349 | PubTator, text mining | PubMed |
1 to 10 of 1,598
See all 1,598 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/88
GET https://conductscience.org/api/genes/v1/88/patents?page=2