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Gene · 8801

SUCLG2: succinate-CoA ligase GDP-forming subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SUCLG2: succinate-CoA ligase GDP-forming subunit beta. Genes, record 8801. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8801

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Gene

Symbol
SUCLG2
HGNC
Name
succinate-CoA ligase GDP-forming subunit beta
HGNC
NCBI Gene ID
8801
NCBI Gene
HGNC ID
HGNC:11450
HGNC
Ensembl
ENSG00000172340
NCBI Gene
Aliases
G-SCS, GBETA, GTPSCS
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96I99Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial4326Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4752548 A12026-06-0312Q96I99Espacenet
EP 4650780 A22025-11-194500Q96I99Espacenet
EP 4641201 A22025-10-294047Q96I99Espacenet
JP 2025517969 A2025-06-124047Q96I99Espacenet
JP 2025517970 A2025-06-124500Q96I99Espacenet
US 11446398 B22022-09-2084794Q96I99Espacenet
JP 2022524081 A2022-04-27187765Q96I99Espacenet
WO 2020043864 A12020-03-052512Q96I99Espacenet
EP 3504344 A12019-07-031245Q96I99Espacenet
JP 2017121240 A2017-07-1354694Q96I99Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,762

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSUCLG2 papersNewest fiscal year
R35GM128641Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation122025
R01MH112205Molecular Details of Psychoactive Drug Actions102025
P30CA016086Cancer Center Support Grant92025
R01DA036596Regulation of Neuronal GPCR Signaling82025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors62025
R35GM118105Negative and positive feedback in cell signaling62025
R35GM122481Development and Testing of New Computational Methods for Ligand Discovery and Mechanism62025
P30CA008748Cancer Center Support Grant52025
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis52025
R01HL142068T Cell Immunity in Giant Cell Arteritis52025

1 to 10 of 1,762Source NIH's project files

See all 1,762 nih grants

Papers2,055

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Multi-omic profiling and pathways related to changes in liver histology after Roux-en-Y gastric bypass: a longitudinal study.EBioMedicine202642810054PubTator, text miningPubMed
Functional diversity in G-protein signalling: In-silico study of G-protein γ subunit induced behavioural alteration in G-protein β subunit hotspot.Int J Biol Macromol202642790561PubTator, text miningPubMed
SUCLG2 contributes to platinum resistance in lung adenocarcinoma through enhancing succinylation of GAC and glutamine metabolism.Apoptosis202642776318PubTator, text miningPubMed
NSUN2 Promotes Cancer Immune Evasion via Its Moonlighting Function Acting on Metabolic Reprogramming.Cancer Commun (Lond)202642620795PubTator, text miningPubMed
The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism.Nat Commun202642457680PubTator, text miningPubMed
A telomerase-SUCLG2 signaling axis drives drug resistance by protecting persister cells.Cell Rep202642418322PubTator, text miningPubMed
Lactate as a Chemical Modification on Proteins and Metabolites.Annu Rev Biochem202642331744PubTator, text miningPubMed
Structural composition and functional diversities of G proteins in fungi.Mycology202642305152PubTator, text miningPubMed
Co-targeting EGFR and SUCLG2 disrupts a nuclear transcriptional program driving neuroendocrine differentiation and TKI resistance in castration-resistant prostate cancer.Cell Commun Signal202642252434PubTator, text miningPubMed
Extra-large G proteins and their roles in plant development and responses to environmental stresses.Front Plant Sci202642164782PubTator, text miningPubMed

1 to 10 of 2,055

See all 2,055 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8801

GET https://conductscience.org/api/genes/v1/8801/patents