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IL18R1: interleukin 18 receptor 1

1 protein, 142 patents, 1 drug, 6 trials, 3,199 NIH grants and 6,344 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL18R1HGNC
Nameinterleukin 18 receptor 1HGNC
NCBI Gene ID8809NCBI Gene
HGNC IDHGNC:5988HGNC
EnsemblENSG00000115604NCBI Gene
AliasesCD218a, CDw218a, IL-18R, IL-18R-alpha, IL-18Ralpha, IL-1Rrp, IL18RA, IL18Ralpha2, IL1RRPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q13478Interleukin-18 receptor 15413Ensembl, GeneID, HGNCUniProt

Patents 142

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26126Q13478Espacenet
JP 2026510989 A2026-04-1067Q13478Espacenet
JP 2026004568 A2026-01-1450198Q13478Espacenet
JP 2026004568 A2026-01-1450200Q13478Espacenet
JP 2026004568 A2026-01-1450201Q13478Espacenet
EP 4650780 A22025-11-19872Q13478Espacenet
JP 2025537484 A2025-11-18287Q13478Espacenet
EP 4641201 A22025-10-29614Q13478Espacenet
WO 2025209797 A12025-10-091Q13478Espacenet
JP 2025147176 A2025-10-066943Q13478Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IBOCTADEKINCHEMBL2108034IL18 Receptor agonistAGONISTChEMBL

Trials 6

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02277392IBOCTADEKINPHASE1ClinicalTrials.gov
NCT01768338IBOCTADEKINPHASE1ClinicalTrials.gov
NCT00659178IBOCTADEKINPHASE1ClinicalTrials.gov
NCT00500058IBOCTADEKINPHASE1ClinicalTrials.gov
NCT00107718IBOCTADEKINPHASE2ClinicalTrials.gov
NCT00085904IBOCTADEKINPHASE1ClinicalTrials.gov

NIH grants 3199

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant192,025NIH's project files
R01AI015614Pathogenesis of Fever in Man182,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)172,025NIH's project files
U19AI082630Durable Alteration of the Human Immune system after Infection or Immunotherapy152,025NIH's project files
P30CA016672Cancer Center Support Grant132,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant92,025NIH's project files
ZIAHD002400The Role Of Subclinical Infection And Cytokines In Preterm Parturition92,025NIH's project files
P30CA016058Cancer Center Support Grant82,025NIH's project files
P30CA023108Cancer Center Support Grant72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files

Papers 6344

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818167PubTator, text miningPubMed
42788350PubTator, text miningPubMed
42781881PubTator, text miningPubMed
42766737PubTator, text miningPubMed
42744106PubTator, text miningPubMed
42707154PubTator, text miningPubMed
42671388PubTator, text miningPubMed
42653451PubTator, text miningPubMed
42621910PubTator, text miningPubMed
42613799PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license