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Gene · 8826

IQGAP1: IQ motif containing GTPase activating protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. IQGAP1: IQ motif containing GTPase activating protein 1. Genes, record 8826. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8826

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Gene

Symbol
IQGAP1
HGNC
Name
IQ motif containing GTPase activating protein 1
HGNC
NCBI Gene ID
8826
NCBI Gene
HGNC ID
HGNC:6110
HGNC
Ensembl
ENSG00000140575
NCBI Gene
Aliases
HUMORFA01, KIAA0051, SAR1, p195
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46940Ras GTPase-activating-like protein IQGAP11,6575Ensembl, GeneID, HGNC

Source UniProt

Patents81

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1450384P46940Espacenet
EP 4650780 A22025-11-192654P46940Espacenet
EP 4641201 A22025-10-292236P46940Espacenet
JP 2025517969 A2025-06-122236P46940Espacenet
JP 2025517970 A2025-06-122654P46940Espacenet
JP 2025032204 A2025-03-1130027P46940Espacenet
EP 4461818 A22024-11-1330027P46940Espacenet
US 11694765 B22023-07-04252P46940Espacenet
US 11694765 B22023-07-04312P46940Espacenet
JP 2023064789 A2023-05-1263P46940Espacenet

1 to 10 of 81

See all 81 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,602

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleIQGAP1 papersNewest fiscal year
ZIACL080017IQGAP1 in tumorigenesis402025
P30CA008748Cancer Center Support Grant122025
R01GM066817The Biochemical Basis for the Mechanics of Cytokinesis62025
ZIABC010441Biomolecular Recognition and Binding Mechanisms62025
P01CA022443Molecular Biology and Genetics of Human Tumor Viruses52025
P30CA014520UW Comprehensive Cancer Center Support52025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
P30CA016672Cancer Center Support Grant52025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
R01EY015130Mechanisms of Angiogenesis in ROP52025

1 to 10 of 1,602Source NIH's project files

See all 1,602 nih grants

Papers2,407

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Tyrosine phosphorylation of the scaffold protein IQGAP1 by VEGFR2 modulates cell proliferation.J Biol Chem202642772568PubTator, text miningPubMed
Upstream regulatory mechanisms and clinical significance of IQGAP2 deficiency in affecting PI3K activity to drive cell proliferation.Hum Cell202642763828PubTator, text miningPubMed
SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics.Int J Mol Sci202642589701PubTator, text miningPubMed
IQGAP Family Proteins in Colorectal Cancer: Molecular Mechanisms and Prognostic Implications.Diagnostics (Basel)202642510017PubTator, text miningPubMed
Integration of lung tissue proteomics and genome-wide association data to identify lung cancer susceptibility proteins and potential drug targets.medRxiv202642396338PubTator, text miningPubMed
Methyl Caffeate Binds to IQGAP1 and Inhibits the Senescence-Associated Secretory Phenotype in Senescent Cells.Int J Mol Sci202642352923PubTator, text miningPubMed
Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy.Antioxidants (Basel)202642352065PubTator, text miningPubMed
PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration.Nat Commun202642285921PubTator, text miningPubMed
Corrigendum to 'IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrin' [Cellular Signalling, 27 (2015) 867-877/CLS-08385].Cell Signal202642264995PubTator, text miningPubMed
Super-enhancer-driven ITGB2-AS1 promotes ovarian cancer progression by binding to IQGAP1.Transl Oncol202642241993PubTator, text miningPubMed

1 to 10 of 2,407

See all 2,407 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8826

GET https://conductscience.org/api/genes/v1/8826/patents?page=2