Gene · 8826
IQGAP1: IQ motif containing GTPase activating protein 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. IQGAP1: IQ motif containing GTPase activating protein 1. Genes, record 8826. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8826
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P46940 | Ras GTPase-activating-like protein IQGAP1 | 1,657 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents81
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 50384 | P46940 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2654 | P46940 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2236 | P46940 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2236 | P46940 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2654 | P46940 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 30027 | P46940 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 30027 | P46940 | Espacenet |
| US 11694765 B2 | 2023-07-04 | 252 | P46940 | Espacenet |
| US 11694765 B2 | 2023-07-04 | 312 | P46940 | Espacenet |
| JP 2023064789 A | 2023-05-12 | 63 | P46940 | Espacenet |
1 to 10 of 81
See all 81 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,602
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | IQGAP1 papers | Newest fiscal year |
|---|---|---|---|
| ZIACL080017 | IQGAP1 in tumorigenesis | 40 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| R01GM066817 | The Biochemical Basis for the Mechanics of Cytokinesis | 6 | 2025 |
| ZIABC010441 | Biomolecular Recognition and Binding Mechanisms | 6 | 2025 |
| P01CA022443 | Molecular Biology and Genetics of Human Tumor Viruses | 5 | 2025 |
| P30CA014520 | UW Comprehensive Cancer Center Support | 5 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 5 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| R01EY015130 | Mechanisms of Angiogenesis in ROP | 5 | 2025 |
1 to 10 of 1,602Source NIH's project files
See all 1,602 nih grantsPapers2,407
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Tyrosine phosphorylation of the scaffold protein IQGAP1 by VEGFR2 modulates cell proliferation. | J Biol Chem | 2026 | 42772568 | PubTator, text mining | PubMed |
| Upstream regulatory mechanisms and clinical significance of IQGAP2 deficiency in affecting PI3K activity to drive cell proliferation. | Hum Cell | 2026 | 42763828 | PubTator, text mining | PubMed |
| SASH1 as a Context-Dependent Multi-Docking Scaffold Linking Receptor Signaling to Cytoskeletal Dynamics. | Int J Mol Sci | 2026 | 42589701 | PubTator, text mining | PubMed |
| IQGAP Family Proteins in Colorectal Cancer: Molecular Mechanisms and Prognostic Implications. | Diagnostics (Basel) | 2026 | 42510017 | PubTator, text mining | PubMed |
| Integration of lung tissue proteomics and genome-wide association data to identify lung cancer susceptibility proteins and potential drug targets. | medRxiv | 2026 | 42396338 | PubTator, text mining | PubMed |
| Methyl Caffeate Binds to IQGAP1 and Inhibits the Senescence-Associated Secretory Phenotype in Senescent Cells. | Int J Mol Sci | 2026 | 42352923 | PubTator, text mining | PubMed |
| Beyond KEAP1: The Context-Specific NRF2 Partner Code in Disease and Therapy. | Antioxidants (Basel) | 2026 | 42352065 | PubTator, text mining | PubMed |
| PAR3-mediated coordination of hepatocyte proliferation, maturation, and architecture in liver development and regeneration. | Nat Commun | 2026 | 42285921 | PubTator, text mining | PubMed |
| Corrigendum to 'IQGAP1 regulates actin cytoskeleton organization in podocytes through interaction with nephrin' [Cellular Signalling, 27 (2015) 867-877/CLS-08385]. | Cell Signal | 2026 | 42264995 | PubTator, text mining | PubMed |
| Super-enhancer-driven ITGB2-AS1 promotes ovarian cancer progression by binding to IQGAP1. | Transl Oncol | 2026 | 42241993 | PubTator, text mining | PubMed |
1 to 10 of 2,407
See all 2,407 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8826
GET https://conductscience.org/api/genes/v1/8826/patents?page=2