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CFLAR: CASP8 and FADD like apoptosis regulator

1 protein, 107 patents, 0 drugs, 0 trials, 3,711 NIH grants and 7,570 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCFLARHGNC
NameCASP8 and FADD like apoptosis regulatorHGNC
NCBI Gene ID8837NCBI Gene
HGNC IDHGNC:1876HGNC
EnsemblENSG00000003402NCBI Gene
AliasesCASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, cFLIPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15519CASP8 and FADD-like apoptosis regulator48017Ensembl, GeneID, HGNCUniProt

Patents 107

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4725503 A22026-04-152636O15519Espacenet
JP 2026035690 A2026-03-042636O15519Espacenet
JP 2026021445 A2026-02-103093O15519Espacenet
JP 2026000906 A2026-01-06198O15519Espacenet
EP 4650780 A22025-11-194837O15519Espacenet
EP 4641202 A22025-10-294878O15519Espacenet
JP 2025517970 A2025-06-124837O15519Espacenet
KR 1020250072712 A2025-05-263093O15519Espacenet
JP 2025069165 A2025-04-301O15519Espacenet
JP 2025062604 A2025-04-1412198O15519Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3711

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant622,025NIH's project files
P30CA008748Cancer Center Support Grant262,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant132,025NIH's project files
P30CA047904Cancer Center Support Grant112,025NIH's project files
P30CA054174Mays Cancer Center at UT Health SA112,025NIH's project files
P30CA016058Cancer Center Support Grant102,025NIH's project files
P30CA068485Cancer Center Support Grant102,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92,025NIH's project files
R37AI044828Survival Function of the Fadd-Caspase-8-Flip Complex - MERIT Extension92,025NIH's project files
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant82,025NIH's project files

Papers 7570

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42805065PubTator, text miningPubMed
42794479PubTator, text miningPubMed
42674249PubTator, text miningPubMed
42661060PubTator, text miningPubMed
42656404PubTator, text miningPubMed
42653075PubTator, text miningPubMed
42612226PubTator, text miningPubMed
42599648PubTator, text miningPubMed
42579423PubTator, text miningPubMed
42552633PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license