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Gene · 8838

CCN6: cellular communication network factor 6

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CCN6: cellular communication network factor 6. Genes, record 8838. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8838

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Gene

Symbol
CCN6
HGNC
Name
cellular communication network factor 6
HGNC
NCBI Gene ID
8838
NCBI Gene
HGNC ID
HGNC:12771
HGNC
Ensembl
ENSG00000112761
NCBI Gene
Aliases
LIBC, PPAC, PPD, PPRD, WISP-3, WISP3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95389Cellular communication network factor 63540Ensembl, GeneID, HGNC

Source UniProt

Patents66

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469932O95389Espacenet
JP 2026004568 A2026-01-1469935O95389Espacenet
EP 4650780 A22025-11-19772O95389Espacenet
EP 4641201 A22025-10-29547O95389Espacenet
JP 2025147176 A2025-10-0614270O95389Espacenet
JP 2025147176 A2025-10-0614271O95389Espacenet
JP 2025147176 A2025-10-0614272O95389Espacenet
JP 2025529142 A2025-09-048077O95389Espacenet
US 12371689 B22025-07-298077O95389Espacenet
JP 2025517969 A2025-06-12547O95389Espacenet

1 to 10 of 66

See all 66 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants669

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCCN6 papersNewest fiscal year
R01CA107469Role of EZH2 in Breast Cancer Progression202025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028152025
P30CA016672Cancer Center Support Grant42025
ZIAAI001065India International Center for Excellence in Research32025
P30AI045008Penn Center for AIDS Research22025
P30AI050409Center for AIDS Research at Emory University22025
P30CA008748Cancer Center Support Grant22025
P30CA014520UW Comprehensive Cancer Center Support22025
P30CA016087Cancer Center Support Grant22025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025

1 to 10 of 669Source NIH's project files

See all 669 nih grants

Papers1,704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Severe Phenotype in an Indian Family With Progressive Pseudorheumatoid Arthropathy of Childhood.Am J Med Genet A202642728239PubTator, text miningPubMed
WISP-3 promotes PDGF-B-mediated angiogenesis through suppression of let-7b-5p in rheumatoid arthritis.Front Immunol202642591462PubTator, text miningPubMed
Transcriptomic comparison of the infrapatellar fat pad between young patients with traumatic knee injury and older patients with knee osteoarthritis.Connect Tissue Res202642560660PubTator, text miningPubMed
WISP-3 promotes tumor-monocyte adhesion through a MEK/ERK-dependent miR-12131/ICAM-4 axis in lung adenocarcinoma.Int J Med Sci202642524377PubTator, text miningPubMed
Cardiorespiratory fitness, adiposity, and metabolic risk in breast cancer survivors: links with circulating WISP-1 and WISP-3.Korean J Physiol Pharmacol202642481430PubTator, text miningPubMed
WISP-3 drives LUAD metastasis by suppressing miR-5004-5p to upregulate MMP-12.Biochem Pharmacol202642349620PubTator, text miningPubMed
Species-specific roles of cellular communication network proteins in cartilage development: A comparative study using in vitro chondrogenic models.J Cell Commun Signal202642256527PubTator, text miningPubMed
Analysis of the current status and influencing factors of latent tuberculosis infection among new students in Taishan District in 2025.Front Public Health202642232943PubTator, text miningPubMed
The Role of the Cellular Communication Network Protein Family in Pulmonary Arterial Hypertension.Pulm Circ202642146788PubTator, text miningPubMed
WISP-3 promotes angiogenesis in non-small cell lung cancer through p38/JNK-c-Jun-mediated PDGF-A upregulation.J Cancer202642038025PubTator, text miningPubMed

1 to 10 of 1,704

See all 1,704 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8838

GET https://conductscience.org/api/genes/v1/8838/patents?page=2