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Gene · 8840

CCN4: cellular communication network factor 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CCN4: cellular communication network factor 4. Genes, record 8840. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8840

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Gene

Symbol
CCN4
HGNC
Name
cellular communication network factor 4
HGNC
NCBI Gene ID
8840
NCBI Gene
HGNC ID
HGNC:12769
HGNC
Ensembl
ENSG00000104415
NCBI Gene
Aliases
WISP-1, WISP1, WISP1-OT1, WISP1-UT1, WISP1c, WISP1i, WISP1tc
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95388CCN family member 43670Ensembl, GeneID, HGNC

Source UniProt

Patents92

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1469925O95388Espacenet
EP 4650780 A22025-11-191298O95388Espacenet
JP 2025147176 A2025-10-0614260O95388Espacenet
JP 2025529142 A2025-09-048075O95388Espacenet
US 12371689 B22025-07-298075O95388Espacenet
JP 2025517970 A2025-06-121298O95388Espacenet
JP 2025028160 A2025-02-2814260O95388Espacenet
JP 2025011102 A2025-01-231O95388Espacenet
KR 1020250010750 A2025-01-2114260O95388Espacenet
JP 2024109657 A2024-08-1414267O95388Espacenet

1 to 10 of 92

See all 92 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants732

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCCN4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant72025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health52025
P20GM103434West Virginia IDeA Network of Biomedical Research Excellence (WV-INBRE)42025
ZIADE000380The role of stem cells in skeletal health and disease42025
P20GM121322Tumor Microenvironment-TME CoBRE32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025
P30CA077598Cancer Center Support Grant32025
P30AG028716Duke Claude D. Pepper Older Americans Independence Center22025
P30CA008748Cancer Center Support Grant22025
P30CA014051Cancer Center Support (Core) Grant22025

1 to 10 of 732Source NIH's project files

See all 732 nih grants

Papers1,415

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
E3 ubiquitin ligase MAGI3‑mediated TAZ ubiquitination suppresses the non‑small cell lung cancer occurrence and development by targeting the Wnt pathway.Int J Oncol202642757476PubTator, text miningPubMed
WISP1 Drives Intestinal Fibrosis in Crohn's Disease via Metabolic and Rho/ROCK/MRTF-Mediated Cytoskeletal Remodeling.Gastroenterology202642612881PubTator, text miningPubMed
Chasing the FoxO in Metabolic Disorders: Novel Considerations for Oxidative Stress, Programmed Cell Death, Wnt, and the Gut Microbiome.Antioxidants (Basel)202642510625PubTator, text miningPubMed
Cardiorespiratory fitness, adiposity, and metabolic risk in breast cancer survivors: links with circulating WISP-1 and WISP-3.Korean J Physiol Pharmacol202642481430PubTator, text miningPubMed
Genomic Evidence Links Inflammation to Residual Pulmonary Vascular Obstruction and Risk of Pulmonary Embolism Recurrence.medRxiv202642465927PubTator, text miningPubMed
Transcriptomic remodeling of bone marrow mesenchymal stromal cells in pediatric B-cell acute lymphoblastic leukemia: a four-gene signature.Transl Pediatr202642433948PubTator, text miningPubMed
In Vivo ORF Overexpression Screening Identifies CCN4 as a Regulator of Glioblastoma Growth Validated Across Multiple Models.Int J Mol Sci202642352948PubTator, text miningPubMed
A Scoping Review of Emerging Treatments in the Pipeline for Idiopathic Pulmonary Fibrosis: Future Perspectives.Biomedicines202642351721PubTator, text miningPubMed
High-Throughput Olink Proteomics Elucidates the Immuno-Neurological Landscape of Gastric Cancer.J Proteome Res202642329880PubTator, text miningPubMed
Immunoinformatics-guided design of a multi-epitope vaccine targeting WISP1 for gastric cancer.BMC Biotechnol202642237149PubTator, text miningPubMed

1 to 10 of 1,415

See all 1,415 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8840

GET https://conductscience.org/api/genes/v1/8840/patents?page=2