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HDAC3: histone deacetylase 3

1 protein, 25 patents, 14 drugs, 659 trials, 4,690 NIH grants and 8,133 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolHDAC3HGNC
Namehistone deacetylase 3HGNC
NCBI Gene ID8841NCBI Gene
HGNC IDHGNC:4854HGNC
EnsemblENSG00000171720NCBI Gene
AliasesHD3, KDAC3, RPD3, RPD3-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15379Histone deacetylase 34281Ensembl, GeneID, HGNCUniProt

Patents 25

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-194181O15379Espacenet
JP 2025517970 A2025-06-124181O15379Espacenet
JP 2024123008 A2024-09-106463O15379Espacenet
JP 2024525602 A2024-07-12333O15379Espacenet
EP 4368713 A12024-05-15333O15379Espacenet
KR 1020220144317 A2022-10-26277O15379Espacenet
US 11446398 B22022-09-2038591O15379Espacenet
JP 2022524081 A2022-04-27141562O15379Espacenet
US 11078247 B22021-08-034905O15379Espacenet
US 10501513 B22019-12-106463O15379Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABEXINOSTATCHEMBL2103863Histone deacetylase inhibitorINHIBITORChEMBL
BELINOSTATCHEMBL408513Histone deacetylase inhibitorINHIBITORChEMBL
CUDC-101CHEMBL598797Histone deacetylase inhibitorINHIBITORChEMBL
ENTINOSTATCHEMBL27759Histone deacetylase inhibitorINHIBITORChEMBL
FIMEPINOSTATCHEMBL3622533Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTATCHEMBL1213492Histone deacetylase inhibitorINHIBITORChEMBL
GIVINOSTAT HYDROCHLORIDECHEMBL6068400Histone deacetylase inhibitorINHIBITORChEMBL
MOCETINOSTATCHEMBL272980Histone deacetylase 3 inhibitorINHIBITORChEMBL
PANOBINOSTATCHEMBL483254Histone deacetylase inhibitorINHIBITORChEMBL
PANOBINOSTAT LACTATECHEMBL3545368Histone deacetylase inhibitorINHIBITORChEMBL

Trials 659

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07492394ENTINOSTATPHASE2ClinicalTrials.gov
NCT07441486ENTINOSTATPHASE2ClinicalTrials.gov
NCT07330544ENTINOSTATPHASE2ClinicalTrials.gov
NCT07261592ENTINOSTATPHASE1/PHASE2ClinicalTrials.gov
NCT07261241VORINOSTATPHASE2ClinicalTrials.gov
NCT07235618ENTINOSTATPHASE2ClinicalTrials.gov
NCT07217379VORINOSTATPHASE1ClinicalTrials.gov
NCT07150026VORINOSTATPHASE1ClinicalTrials.gov
NCT07150013VORINOSTATPHASE1ClinicalTrials.gov
NCT06995521VORINOSTATPHASE2ClinicalTrials.gov

NIH grants 4690

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant382,025NIH's project files
R01DK043806Integrative Physiology of Thyroid Hormone Receptors and Nuclear Receptor Corepressors282,025NIH's project files
P30DK019525University of Pennsylvania Diabetes Research Center272,025NIH's project files
P30CA068485Cancer Center Support Grant232,025NIH's project files
P30CA008748Cancer Center Support Grant212,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant152,025NIH's project files
R01GM049758Structure and Function of Metalloenzymes152,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases132,025NIH's project files
P30EY016665Core Grant for Vision Research122,025NIH's project files
T32AR056950Musculoskeletal Research Training Program122,025NIH's project files

Papers 8133

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42800422PubTator, text miningPubMed
42798903PubTator, text miningPubMed
42792516PubTator, text miningPubMed
42781328PubTator, text miningPubMed
42774120PubTator, text miningPubMed
42749627PubTator, text miningPubMed
42731468PubTator, text miningPubMed
42729152PubTator, text miningPubMed
42722174PubTator, text miningPubMed
42685527PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license