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Gene · 8843

HCAR3: hydroxycarboxylic acid receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HCAR3: hydroxycarboxylic acid receptor 3. Genes, record 8843. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8843

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Gene

Symbol
HCAR3
HGNC
Name
hydroxycarboxylic acid receptor 3
HGNC
NCBI Gene ID
8843
NCBI Gene
HGNC ID
HGNC:16824
HGNC
Ensembl
ENSG00000255398
NCBI Gene
Aliases
GPR109B, HCA3, HM74, PUMAG, Puma-g
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49019Hydroxycarboxylic acid receptor 338711Ensembl, GeneID, HGNC

Source UniProt

Patents18

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-041919P49019Espacenet
US 12371689 B22025-07-291919P49019Espacenet
JP 2025024198 A2025-02-1913002P49019Espacenet
WO 2024252368 A22024-12-1238P49019Espacenet
US 11446398 B22022-09-2039219P49019Espacenet
JP 2022524081 A2022-04-27142190P49019Espacenet
US 11078247 B22021-08-034888P49019Espacenet
US 10772934 B22020-09-151284P49019Espacenet
US 9827332 B22017-11-2813002P49019Espacenet
US 9782454 B22017-10-101284P49019Espacenet

1 to 10 of 18

See all 18 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,075

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHCAR3 papersNewest fiscal year
ZIABC007365Regulation of ADP-ribosylation factor122025
P30CA008748Cancer Center Support Grant62025
P30CA016058Cancer Center Support Grant62025
R01DK048370Small GTP Binding Proteins in Gastrointestinal Mucosa42025
P30CA013330Cancer Center Support Grant32025
P30CA016672Cancer Center Support Grant32025
P30CA051008Georgetown University Lombardi Comprehensive Cancer Center Support Grant32025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)32025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis32025
R01HL045638Programming of PMN host-defense function during transendothelial migration32025

1 to 10 of 2,075Source NIH's project files

See all 2,075 nih grants

Papers3,413

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Gut microbiota-derived metabolites target C5AR1/KDM2A/HCAR3 axis in inflammatory bowel disease: a multi-machine learning algorithms and molecular docking study.Front Cell Infect Microbiol202642698445PubTator, text miningPubMed
GTP-binding protein DIRAS2 inhibits ferroptosis in oral leukoplakia via regulating iron metabolism.Eur J Cell Biol202642632312PubTator, text miningPubMed
Targeting GEM Reprograms Macrophages and Overcomes Immunotherapy Resistance in Esophageal Squamous Cell Carcinoma.Cancer Res202642561099PubTator, text miningPubMed
Cigarette Smoke-Induced Alveolar Macrophage Senescence via GEM/SIRT3-Mediated Mitochondrial Dysfunction.Adv Sci (Weinh)202642325089PubTator, text miningPubMed
Comparative analysis reveals molecular adaptation of mammalian HCA2 to microbial metabolites.iScience202642221821PubTator, text miningPubMed
Implications of ADP-Ribosylation Factor-Like Protein 4C (ARL4C) in Human Neoplasia With Special Emphasis on Ameloblastoma: A Scoping Review.J Oral Pathol Med202642206730PubTator, text miningPubMed
Evolutionary History and Functional Divergence of Hydroxycarboxylic Acid Receptors in Primates.Genome Biol Evol202642186840PubTator, text miningPubMed
Development of ARL4C antisense oligonucleotide with reduced off-target effects and enhanced efficacy as an anti-cancer drug.In Vitro Cell Dev Biol Anim202641792408PubTator, text miningPubMed
Temporal Transcriptomic and Metabolomic Reprogramming Unveils a Two-Phase Salt Tolerance Mechanism in Apocynum venetum.Int J Mol Sci202641752054PubTator, text miningPubMed
A Machine Learning-Guided Approach for Identifying Potential HCAR1 Antagonists in Lactate-Driven Cancers.ACS Omega202641726659PubTator, text miningPubMed

1 to 10 of 3,413

See all 3,413 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8843

GET https://conductscience.org/api/genes/v1/8843/patents