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Gene · 8851

CDK5R1: cyclin dependent kinase 5 regulatory subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CDK5R1: cyclin dependent kinase 5 regulatory subunit 1. Genes, record 8851. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8851

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Gene

Symbol
CDK5R1
HGNC
Name
cyclin dependent kinase 5 regulatory subunit 1
HGNC
NCBI Gene ID
8851
NCBI Gene
HGNC ID
HGNC:1775
HGNC
Ensembl
ENSG00000176749
NCBI Gene
Aliases
CDK5P35, CDK5R, NCK5A, Nck5a, p23, p25, p35, p35nck5a
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q15078Cyclin-dependent kinase 5 activator 130711Ensembl, GeneID, HGNC

Source UniProt

Patents30

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2024123008 A2024-09-105791Q15078Espacenet
US 11708396 B22023-07-251578Q15078Espacenet
JP 2022147356 A2022-10-06309Q15078Espacenet
US 11446398 B22022-09-2021314Q15078Espacenet
JP 2022524081 A2022-04-27124285Q15078Espacenet
US 11078247 B22021-08-031941Q15078Espacenet
US 10501513 B22019-12-105791Q15078Espacenet
JP 2018183181 A2018-11-226562Q15078Espacenet
JP 2017197545 A2017-11-0230492Q15078Espacenet
JP 2017113010 A2017-06-296562Q15078Espacenet

1 to 10 of 30

See all 30 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,908

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCDK5R1 papersNewest fiscal year
ZIADE000664Characterization of Molecular Pathways in Chronic Pain Conditions132025
P30CA008748Cancer Center Support Grant112025
P30CA016672Cancer Center Support Grant102025
ZIASC010074HSP90 and HSP70 Chaperone Proteins and Interactors in Cellular Signal Transduction82025
ZIABC011032Post-translational modifications of Hsp9072025
P30MH062512HIV Neurobehavioral Research Center62025
P30CA036727Buffett Cancer Center Support Grant42025
P30DA018343Yale/NIDA Neuroproteomics Center42025
ZIANS003106Roles of Cdk5 in neurodevelopment and neurodegeneration42025
P40OD018537Bloomington Drosophila Stock Center at Indiana University32025

1 to 10 of 1,908Source NIH's project files

See all 1,908 nih grants

Papers2,831

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Exploration of the Key Mechanism by Which Kaempferol Inhibits Glycolysis in Hepatocellular Carcinoma Cells via the AKT-mTOR Pathway.FASEB J202642322592PubTator, text miningPubMed
A patent review of cyclin-dependent kinase 5 (CDK5) inhibitors (1999-2025).Front Bioeng Biotechnol202642312138PubTator, text miningPubMed
Spatial Transcriptomics Delineates the Inflammatory Landscape of Human Dental Pulp: Regional Crosstalk and Therapeutic Implications.Int Endod J202642295016PubTator, text miningPubMed
CDK5-p25 Peptide Inhibitor Samples an Intrinsically Disordered Ensemble in Solution.J Phys Chem B202642284526PubTator, text miningPubMed
Exploration and validation of potential diagnostic biomarkers of PANoptosis in periodontitis using bioinformatics approaches.Biochem Biophys Res Commun202642172897PubTator, text miningPubMed
The Recycling Endosomal (Na+, K+)/H+ Exchanger NHE6/SLC9A6 Facilitates Signal Transduction by Shuttling Cyclin-Dependent Kinase 5 to the Plasma Membrane.Acta Physiol (Oxf)202642051037PubTator, text miningPubMed
New Pathological Insights into Biomarkers for Multimodal Therapeutic Approach in Hepatic Neuroendocrine Tumors: A Detailed Case Report.In Vivo202642049452PubTator, text miningPubMed
DNA Methylation Regulates CDK5R1 and NRBP1 to Exert Effects on Alcohol Dependence: Insights From Mendelian Randomization.Addict Biol202642025296PubTator, text miningPubMed
Programmed cell death: a promising management for Alzheimer's disease.Apoptosis202641904723PubTator, text miningPubMed
HSP90 inhibition potentiates oxidant-based antimelanoma action of novel thioquercetin derivatives by compromising AhR/CYP1A1 pathway.Apoptosis202641903067PubTator, text miningPubMed

1 to 10 of 2,831

See all 2,831 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8851

GET https://conductscience.org/api/genes/v1/8851/patents?page=2