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Gene · 8854

ALDH1A2: aldehyde dehydrogenase 1 family member A2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ALDH1A2: aldehyde dehydrogenase 1 family member A2. Genes, record 8854. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8854

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Gene

Symbol
ALDH1A2
HGNC
Name
aldehyde dehydrogenase 1 family member A2
HGNC
NCBI Gene ID
8854
NCBI Gene
HGNC ID
HGNC:15472
HGNC
Ensembl
ENSG00000128918
NCBI Gene
Aliases
DIH4, RALDH(II), RALDH2, RALDH2-T
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O94788Retinal dehydrogenase 25187Ensembl, GeneID, HGNC

Source UniProt

Patents16

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436987O94788Espacenet
EP 4641201 A22025-10-29916O94788Espacenet
JP 2025517969 A2025-06-12916O94788Espacenet
JP 2025062604 A2025-04-143831O94788Espacenet
JP 2024178415 A2024-12-248103O94788Espacenet
US 11446398 B22022-09-203831O94788Espacenet
JP 2022529532 A2022-06-228103O94788Espacenet
JP 2022524081 A2022-04-27106802O94788Espacenet
JP 2022512686 A2022-02-075O94788Espacenet
EP 3863646 A12021-08-185O94788Espacenet

1 to 10 of 16

See all 16 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,477

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleALDH1A2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
R01HD010808Hormonal Regulation Sertoli Cell Maturation72025
R01AA011147Ethanol and aldehyde dehydrogenases in health and disease62025
P30CA008748Cancer Center Support Grant52025
P30CA016058Cancer Center Support Grant52025
P30DK017047Diabetes Research Center42025
T32CA101642Training of Academic Gynecologic Oncologists42025
T32DK007247Diabetes, Obesity and Metabolism Training Program42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA015704Cancer Center Support Grant32025

1 to 10 of 1,477Source NIH's project files

See all 1,477 nih grants

Papers1,746

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting the ALDH-RA Axis with RE-Exo@HA hydrogel to achieve scarless endometrial regeneration and fertility restoration in intrauterine adhesions.J Control Release202642641931PubTator, text miningPubMed
A synergistic deep learning and machine learning framework for screening heterocyclic compounds against ALDH1A1.Mol Divers202642530797PubTator, text miningPubMed
Machine Learning-Guided Multi-Cohort Transcriptomic Profiling Identifies SPON1 and ALDH1A2 as Diagnostic and Prognostic Biomarkers Linked to the Immune Microenvironment in High-Grade Serous Carcinoma.Int J Mol Sci202642511606PubTator, text miningPubMed
The immunological landscape of the area postrema in neuromyelitis optica spectrum disorders.Brain Pathol202642503643PubTator, text miningPubMed
WNT signaling in human pluripotent stem cells promotes HDAC2-dependent epigenetic programs and development of retinoic acid-responsive mesoderm.Stem Cell Reports202642314670PubTator, text miningPubMed
Personalized polygenic profiling based on the genetic architecture of lipid metabolism in the Russian population.Front Cardiovasc Med202642311766PubTator, text miningPubMed
Genome-wide analysis implicates inner ear development in Ménière disease.Am J Hum Genet202642302782PubTator, text miningPubMed
Integrative genomic analysis of 21 orofacial diseases identifies shared genetic architecture with systemic diseases.Nat Commun202642243103PubTator, text miningPubMed
Integrating AI in Medicinal Chemistry for Accelerated Drug Discovery: A Comprehensive SAR (CSAR) Optimization Strategy and Discovery of Potent ALDH3A1 Inhibitors.J Med Chem202642216908PubTator, text miningPubMed
Identification and characterization of a novel aldehyde metabolite of WIN18,446 and associated WIN18,446-ALDH1A2 protein adducts using mass spectrometry.Drug Metab Rev202642124481PubTator, text miningPubMed

1 to 10 of 1,746

See all 1,746 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8854

GET https://conductscience.org/api/genes/v1/8854/patents