Gene · 8879
SGPL1: sphingosine-1-phosphate lyase 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SGPL1: sphingosine-1-phosphate lyase 1. Genes, record 8879. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8879
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95470 | Sphingosine-1-phosphate lyase 1 | 568 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents27
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9266 | O95470 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3937 | O95470 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3937 | O95470 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9266 | O95470 | Espacenet |
| EP 4380602 A2 | 2024-06-12 | 1 | O95470 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 83465 | O95470 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 2926 | O95470 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 186436 | O95470 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 10202 | O95470 | Espacenet |
| JP 2017121240 A | 2017-07-13 | 54599 | O95470 | Espacenet |
1 to 10 of 27
See all 27 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,307
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SGPL1 papers | Newest fiscal year |
|---|---|---|---|
| P01CA097132 | Sphingolipids in Cancer Biology and Therapy | 12 | 2025 |
| R01EY017699 | Functions of the thalamus in attention and perception | 7 | 2025 |
| P30CA016059 | Massey Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30DK056341 | Washington University Nutrition Obesity Research Center | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| R35GM119455 | Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases | 3 | 2025 |
| T32DC000013 | RESEARCH IN HUMAN COMMUNICATION AND ITS DISORDERS | 3 | 2025 |
| K01DC019178 | Rehabilitation of Reading Deficits in Subacute Stroke using fMRI Neurofeedback and Motor Imagery | 2 | 2025 |
| P20GM113132 | The Institute for Biomolecular Targeting | 2 | 2025 |
1 to 10 of 1,307Source NIH's project files
See all 1,307 nih grantsPapers2,207
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated Transcriptomic and Biochemical Profiling Reveals the Regulatory Mechanism of Light Intensity-Induced Anthocyanin Biosynthesis in a Purple-Leaf Tea Cultivar. | Plants (Basel) | 2026 | 42796836 | PubTator, text mining | PubMed |
| Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia. | Insects | 2026 | 42783271 | PubTator, text mining | PubMed |
| Single-Cell RNA Sequencing Reveals T-Cell Metabolic Activation and SGPL1 as a Candidate Predictor of PD-1 Resistance in Urothelial Carcinoma. | Pharmaceuticals (Basel) | 2026 | 42653780 | PubTator, text mining | PubMed |
| Evaluating the Impact of hydration on electrodermal activity: A Comparison between AC bioimpedance and DC skin potential metrics. | J Electr Bioimpedance | 2026 | 42542822 | PubTator, text mining | PubMed |
| The miR156h-TaSPL4-TaPIN18 Module Regulates Plant Architecture and Grain Size by Modulating Auxin Transport in Wheat. | Plant Cell Environ | 2026 | 42387336 | PubTator, text mining | PubMed |
| Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients. | Front Immunol | 2026 | 42327791 | PubTator, text mining | PubMed |
| Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause. | Front Endocrinol (Lausanne) | 2026 | 42290847 | PubTator, text mining | PubMed |
| Anthocyanin biosynthesis in blueberry is regulated by light and abscisic acid signaling via a VcABF2-miR156-VcSPL9 feedback loop. | New Phytol | 2026 | 42271177 | PubTator, text mining | PubMed |
| Exploring the nutritional and bioactive potential of microalgal sulfated polysaccharides for functional food applications. | Food Sci Biotechnol | 2026 | 42148214 | PubTator, text mining | PubMed |
| Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy. | J Clin Invest | 2026 | 42024444 | PubTator, text mining | PubMed |
1 to 10 of 2,207
See all 2,207 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8879
GET https://conductscience.org/api/genes/v1/8879/patents?page=2