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Gene · 8879

SGPL1: sphingosine-1-phosphate lyase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SGPL1: sphingosine-1-phosphate lyase 1. Genes, record 8879. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8879

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Gene

Symbol
SGPL1
HGNC
Name
sphingosine-1-phosphate lyase 1
HGNC
NCBI Gene ID
8879
NCBI Gene
HGNC ID
HGNC:10817
HGNC
Ensembl
ENSG00000166224
NCBI Gene
Aliases
NPHS14, RENI, S1PL, SPL
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95470Sphingosine-1-phosphate lyase 15682Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199266O95470Espacenet
JP 2025529142 A2025-09-043937O95470Espacenet
US 12371689 B22025-07-293937O95470Espacenet
JP 2025517970 A2025-06-129266O95470Espacenet
EP 4380602 A22024-06-121O95470Espacenet
US 11446398 B22022-09-2083465O95470Espacenet
US 11400116 B22022-08-022926O95470Espacenet
JP 2022524081 A2022-04-27186436O95470Espacenet
US 11078247 B22021-08-0310202O95470Espacenet
JP 2017121240 A2017-07-1354599O95470Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,307

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSGPL1 papersNewest fiscal year
P01CA097132Sphingolipids in Cancer Biology and Therapy122025
R01EY017699Functions of the thalamus in attention and perception72025
P30CA016059Massey Cancer Center - Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30DK056341Washington University Nutrition Obesity Research Center42025
P30CA008748Cancer Center Support Grant32025
R35GM119455Mechanisms of Phosphorylation Signaling by Phosphoprotein Phosphatases32025
T32DC000013RESEARCH IN HUMAN COMMUNICATION AND ITS DISORDERS32025
K01DC019178Rehabilitation of Reading Deficits in Subacute Stroke using fMRI Neurofeedback and Motor Imagery22025
P20GM113132The Institute for Biomolecular Targeting22025

1 to 10 of 1,307Source NIH's project files

See all 1,307 nih grants

Papers2,207

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated Transcriptomic and Biochemical Profiling Reveals the Regulatory Mechanism of Light Intensity-Induced Anthocyanin Biosynthesis in a Purple-Leaf Tea Cultivar.Plants (Basel)202642796836PubTator, text miningPubMed
Function of HIF-1α in Regulating Sphingolipid Metabolism and Alleviating Oxidative Stress Damage in Callosobruchus chinensis Under Hypoxia.Insects202642783271PubTator, text miningPubMed
Single-Cell RNA Sequencing Reveals T-Cell Metabolic Activation and SGPL1 as a Candidate Predictor of PD-1 Resistance in Urothelial Carcinoma.Pharmaceuticals (Basel)202642653780PubTator, text miningPubMed
Evaluating the Impact of hydration on electrodermal activity: A Comparison between AC bioimpedance and DC skin potential metrics.J Electr Bioimpedance202642542822PubTator, text miningPubMed
The miR156h-TaSPL4-TaPIN18 Module Regulates Plant Architecture and Grain Size by Modulating Auxin Transport in Wheat.Plant Cell Environ202642387336PubTator, text miningPubMed
Staphylococcus aureus serine protease-like protein B elicits a type 1/type 2 immune response in atopic dermatitis patients.Front Immunol202642327791PubTator, text miningPubMed
Familial glucocorticoid deficiency due to a novel TXNRD2 variant: expanding the spectrum of a rare genetic cause.Front Endocrinol (Lausanne)202642290847PubTator, text miningPubMed
Anthocyanin biosynthesis in blueberry is regulated by light and abscisic acid signaling via a VcABF2-miR156-VcSPL9 feedback loop.New Phytol202642271177PubTator, text miningPubMed
Exploring the nutritional and bioactive potential of microalgal sulfated polysaccharides for functional food applications.Food Sci Biotechnol202642148214PubTator, text miningPubMed
Redirection of sphingolipid metabolism drives cytoskeletal defects in SPLIS and reveals ROCK inhibition as therapy.J Clin Invest202642024444PubTator, text miningPubMed

1 to 10 of 2,207

See all 2,207 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

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