Gene · 8894
EIF2S2: eukaryotic translation initiation factor 2 subunit beta
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. EIF2S2: eukaryotic translation initiation factor 2 subunit beta. Genes, record 8894. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8894
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P20042 | Eukaryotic translation initiation factor 2 subunit 2 | 333 | 17 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 9553 | P20042 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9553 | P20042 | Espacenet |
| EP 4519435 A2 | 2025-03-12 | 28 | P20042 | Espacenet |
| US 11564998 B2 | 2023-01-31 | 6459 | P20042 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 28621 | P20042 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 131592 | P20042 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 3461 | P20042 | Espacenet |
| US 10463751 B2 | 2019-11-05 | 6459 | P20042 | Espacenet |
| JP 2018023373 A | 2018-02-15 | 29186 | P20042 | Espacenet |
| US 9572897 B2 | 2017-02-21 | 6459 | P20042 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,150
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | EIF2S2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD001004 | Molecular Mechanisms of Translational Control | 25 | 2025 |
| ZIAHD001010 | Mechanism and Regulation of Eukaryotic Protein Synthesis | 15 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 14 | 2025 |
| P30CA013330 | Cancer Center Support Grant | 9 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 8 | 2025 |
| R01DK060596 | Translational control by nutrients | 8 | 2025 |
| P20GM103418 | Kansas IDeA Network of Biomedical Research Excellence 5 | 7 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 5 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 5 | 2025 |
1 to 10 of 2,150Source NIH's project files
See all 2,150 nih grantsPapers3,014
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A novel minimally invasive diagnostic approach of various brain malignancies based on differential miRNA expression. | J Neurooncol | 2026 | 42809056 | PubTator, text mining | PubMed |
| DNL343 and Disease Progression in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial. | JAMA Netw Open | 2026 | 42771346 | PubTator, text mining | PubMed |
| Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma-Jurkat T Cell Coculture Model: A Multi-Omics Analysis. | ACS Omega | 2026 | 42396083 | PubTator, text mining | PubMed |
| Allosteric disordering of eIF2B regulates the integrated stress response. | Nat Chem Biol | 2026 | 42373951 | PubTator, text mining | PubMed |
| Characterization of lactylation-related subtypes and diagnostic markers in myocardial ischemic reperfusion injury using weighted gene coexpression network analysis and machine learning. | Front Immunol | 2026 | 42093976 | PubTator, text mining | PubMed |
| A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response. | Nat Commun | 2026 | 42091608 | PubTator, text mining | PubMed |
| An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity. | J Biol Chem | 2026 | 42031169 | PubTator, text mining | PubMed |
| Systematic review of the molecular basis for cavernous sinus invasion in somatotropinomas. | Endocr Relat Cancer | 2026 | 41989873 | PubTator, text mining | PubMed |
| Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults. | J Cachexia Sarcopenia Muscle | 2026 | 41933456 | PubTator, text mining | PubMed |
| Stress granules at the crossroads of retroviral replication and antiviral immunity: mechanisms and therapeutic opportunities. | Mol Biol Rep | 2026 | 41931190 | PubTator, text mining | PubMed |
1 to 10 of 3,014
See all 3,014 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8894
GET https://conductscience.org/api/genes/v1/8894/patents?page=2