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Gene · 8894

EIF2S2: eukaryotic translation initiation factor 2 subunit beta

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. EIF2S2: eukaryotic translation initiation factor 2 subunit beta. Genes, record 8894. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8894

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Gene

Symbol
EIF2S2
HGNC
Name
eukaryotic translation initiation factor 2 subunit beta
HGNC
NCBI Gene ID
8894
NCBI Gene
HGNC ID
HGNC:3266
HGNC
Ensembl
ENSG00000125977
NCBI Gene
Aliases
EIF2, EIF2B, EIF2beta, PPP1R67, eIF-2-beta
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P20042Eukaryotic translation initiation factor 2 subunit 233317Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-199553P20042Espacenet
JP 2025517970 A2025-06-129553P20042Espacenet
EP 4519435 A22025-03-1228P20042Espacenet
US 11564998 B22023-01-316459P20042Espacenet
US 11446398 B22022-09-2028621P20042Espacenet
JP 2022524081 A2022-04-27131592P20042Espacenet
US 11078247 B22021-08-033461P20042Espacenet
US 10463751 B22019-11-056459P20042Espacenet
JP 2018023373 A2018-02-1529186P20042Espacenet
US 9572897 B22017-02-216459P20042Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,150

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleEIF2S2 papersNewest fiscal year
ZIAHD001004Molecular Mechanisms of Translational Control252025
ZIAHD001010Mechanism and Regulation of Eukaryotic Protein Synthesis152025
P30CA016672Cancer Center Support Grant142025
P30CA013330Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant82025
P30CA016086Cancer Center Support Grant82025
R01DK060596Translational control by nutrients82025
P20GM103418Kansas IDeA Network of Biomedical Research Excellence 572025
P30CA013148Comprehensive Cancer Center Support Grant52025
P30CA016058Cancer Center Support Grant52025

1 to 10 of 2,150Source NIH's project files

See all 2,150 nih grants

Papers3,014

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A novel minimally invasive diagnostic approach of various brain malignancies based on differential miRNA expression.J Neurooncol202642809056PubTator, text miningPubMed
DNL343 and Disease Progression in Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.JAMA Netw Open202642771346PubTator, text miningPubMed
Cannabidiol Activates Integrated Stress Response Signaling and Immune Trafficking Programs in an A375 Melanoma-Jurkat T Cell Coculture Model: A Multi-Omics Analysis.ACS Omega202642396083PubTator, text miningPubMed
Allosteric disordering of eIF2B regulates the integrated stress response.Nat Chem Biol202642373951PubTator, text miningPubMed
Characterization of lactylation-related subtypes and diagnostic markers in myocardial ischemic reperfusion injury using weighted gene coexpression network analysis and machine learning.Front Immunol202642093976PubTator, text miningPubMed
A molecular stabiliser of an inhibitory eIF2B-eIF2(αP) complex activates the Integrated Stress Response.Nat Commun202642091608PubTator, text miningPubMed
An inhibitor of GCN2 and the integrated stress response directly targets ZAK protein kinase to limit cytotoxicity.J Biol Chem202642031169PubTator, text miningPubMed
Systematic review of the molecular basis for cavernous sinus invasion in somatotropinomas.Endocr Relat Cancer202641989873PubTator, text miningPubMed
Skeletal Muscle and Circulating microRNAs Adaptations to 12-Week HIIT With or Without L-Citrulline in Obese Older Adults.J Cachexia Sarcopenia Muscle202641933456PubTator, text miningPubMed
Stress granules at the crossroads of retroviral replication and antiviral immunity: mechanisms and therapeutic opportunities.Mol Biol Rep202641931190PubTator, text miningPubMed

1 to 10 of 3,014

See all 3,014 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8894

GET https://conductscience.org/api/genes/v1/8894/patents?page=2