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Gene · 8911

CACNA1I: calcium voltage-gated channel subunit alpha1 I

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA1I: calcium voltage-gated channel subunit alpha1 I. Genes, record 8911. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8911

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Gene

Symbol
CACNA1I
HGNC
Name
calcium voltage-gated channel subunit alpha1 I
HGNC
NCBI Gene ID
8911
NCBI Gene
HGNC ID
HGNC:1396
HGNC
Ensembl
ENSG00000100346
NCBI Gene
Aliases
Cav3.3, NEDSIS, ca(v)3.3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9P0X4Voltage-dependent T-type calcium channel subunit alpha-1I2,2234Ensembl, GeneID, HGNC

Source UniProt

Patents20

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439680Q9P0X4Espacenet
EP 4640849 A22025-10-291905Q9P0X4Espacenet
EP 4641201 A22025-10-2912682Q9P0X4Espacenet
JP 2025529142 A2025-09-04695Q9P0X4Espacenet
US 12371689 B22025-07-29695Q9P0X4Espacenet
JP 2025519096 A2025-06-241905Q9P0X4Espacenet
JP 2025517969 A2025-06-1212682Q9P0X4Espacenet
JP 2025062604 A2025-04-1410827Q9P0X4Espacenet
US 11446398 B22022-09-2010827Q9P0X4Espacenet
US 11400116 B22022-08-024768Q9P0X4Espacenet

1 to 10 of 20

See all 20 patents

Drugs20

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APINOCALTAMIDECHEMBL4217292Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
ETHOSUXIMIDECHEMBL696Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
METHSUXIMIDECHEMBL697Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
MIBEFRADILCHEMBL45816Voltage-gated T-type calcium channel blockerBLOCKERChEMBL

1 to 10 of 20

See all 20 drugs

Trials386

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants603

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1I papersNewest fiscal year
R01NS055251Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors42025
P30CA012197Cancer Center Support Grant32025
R35GM141802Voltage-gated calcium channels as target for anesthetics32025
T32MH020068Interdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program.32025
UL1TR001863Yale Clinical and Translational Science Award32025
I01BX004500Basal forebrain regulation of default mode and task-on functional network activity: translational modeling of psychiatric disorders22025
R01HL128368Engineered Stem Cells for Cardiac Repair22025
R01MH092638Offline memory processing in schizophrenia22025
T32AA007565Multidisciplinary Training in the Biology of Alcohol Addiction22025
T32HL007901Training in Sleep, Circadian, and Respiratory Neurobiology22025

1 to 10 of 603Source NIH's project files

See all 603 nih grants

Papers751

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Antihypertensive drug targets and pancreatitis reporting signals: An integrative mendelian randomization and FAERS pharmacovigilance study.Sci Prog202642765498PubTator, text miningPubMed
The expanding role of Cav3 channels in glioblastoma.Trends Pharmacol Sci202642697770PubTator, text miningPubMed
Multimodal evidence for a mechanistic model of working memory deficits in schizophrenia.medRxiv202642428116PubTator, text miningPubMed
Identifying genetics biomarkers in correlation with pathological and PSMA PET/CT characteristics in prostate cancer.EJNMMI Res202642400802PubTator, text miningPubMed
Molecular Pharmacology of T-Type Calcium Channels and Their Roles in Neurological Disorders.Med Res Rev202642272247PubTator, text miningPubMed
Computational Modelling of Novelty Detection in the Mismatch Negativity Protocols and Its Impairments in Schizophrenia.Eur J Neurosci202641862424PubTator, text miningPubMed
Autism Spectrum Disorder Associated With a CACNA1I Variant of Uncertain Significance: A Case Report.Cureus202641798403PubTator, text miningPubMed
Protocatechualdehyde-functionalized BMSC-derived exosomes orchestrate calcium signaling in the immunoinflammatory microenvironment to promote periodontal regeneration.J Nanobiotechnology202641794751PubTator, text miningPubMed
Child Neurology: Multiple Genetic Etiologies Causing Dandy-Walker Variant With Microcephaly, Epilepsy, and Global Developmental Delay.Neurology202641791021PubTator, text miningPubMed
Advances in calcium signalling research for the diagnosis and treatment of depression.Ann Med202641787814PubTator, text miningPubMed

1 to 10 of 751

See all 751 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8911

GET https://conductscience.org/api/genes/v1/8911/patents