Gene · 8911
CACNA1I: calcium voltage-gated channel subunit alpha1 I
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CACNA1I: calcium voltage-gated channel subunit alpha1 I. Genes, record 8911. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8911
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q9P0X4 | Voltage-dependent T-type calcium channel subunit alpha-1I | 2,223 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents20
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39680 | Q9P0X4 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1905 | Q9P0X4 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 12682 | Q9P0X4 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 695 | Q9P0X4 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 695 | Q9P0X4 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 1905 | Q9P0X4 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 12682 | Q9P0X4 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10827 | Q9P0X4 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 10827 | Q9P0X4 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 4768 | Q9P0X4 | Espacenet |
1 to 10 of 20
See all 20 patentsDrugs20
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| APINOCALTAMIDE | CHEMBL4217292 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
| ATAGABALIN | CHEMBL593430 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| BEPRIDIL | CHEMBL1008 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| BEPRIDIL HYDROCHLORIDE | CHEMBL1200382 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| ETHOSUXIMIDE | CHEMBL696 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
| GABAPENTIN | CHEMBL940 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| GABAPENTIN ENACARBIL | CHEMBL1628502 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| IMAGABALIN | CHEMBL2103836 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| METHSUXIMIDE | CHEMBL697 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
| MIBEFRADIL | CHEMBL45816 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
1 to 10 of 20
See all 20 drugsTrials386
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07606638 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07598474 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07429734 | GABAPENTIN | PHASE3 | ClinicalTrials.gov | |
| NCT07382921 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07344467 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230197 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230171 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07208357 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07196657 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07186751 | PREGABALIN | ClinicalTrials.gov |
1 to 10 of 386
See all 386 trialsNIH grants603
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CACNA1I papers | Newest fiscal year |
|---|---|---|---|
| R01NS055251 | Voltage-Gated Calcium Channels in Nociceptors and Mechanoreceptors | 4 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 3 | 2025 |
| R35GM141802 | Voltage-gated calcium channels as target for anesthetics | 3 | 2025 |
| T32MH020068 | Interdisciplinary Predoctoral Neuroscience Training Program in the Neuroscience Graduate Program. | 3 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 3 | 2025 |
| I01BX004500 | Basal forebrain regulation of default mode and task-on functional network activity: translational modeling of psychiatric disorders | 2 | 2025 |
| R01HL128368 | Engineered Stem Cells for Cardiac Repair | 2 | 2025 |
| R01MH092638 | Offline memory processing in schizophrenia | 2 | 2025 |
| T32AA007565 | Multidisciplinary Training in the Biology of Alcohol Addiction | 2 | 2025 |
| T32HL007901 | Training in Sleep, Circadian, and Respiratory Neurobiology | 2 | 2025 |
1 to 10 of 603Source NIH's project files
See all 603 nih grantsPapers751
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Antihypertensive drug targets and pancreatitis reporting signals: An integrative mendelian randomization and FAERS pharmacovigilance study. | Sci Prog | 2026 | 42765498 | PubTator, text mining | PubMed |
| The expanding role of Cav3 channels in glioblastoma. | Trends Pharmacol Sci | 2026 | 42697770 | PubTator, text mining | PubMed |
| Multimodal evidence for a mechanistic model of working memory deficits in schizophrenia. | medRxiv | 2026 | 42428116 | PubTator, text mining | PubMed |
| Identifying genetics biomarkers in correlation with pathological and PSMA PET/CT characteristics in prostate cancer. | EJNMMI Res | 2026 | 42400802 | PubTator, text mining | PubMed |
| Molecular Pharmacology of T-Type Calcium Channels and Their Roles in Neurological Disorders. | Med Res Rev | 2026 | 42272247 | PubTator, text mining | PubMed |
| Computational Modelling of Novelty Detection in the Mismatch Negativity Protocols and Its Impairments in Schizophrenia. | Eur J Neurosci | 2026 | 41862424 | PubTator, text mining | PubMed |
| Autism Spectrum Disorder Associated With a CACNA1I Variant of Uncertain Significance: A Case Report. | Cureus | 2026 | 41798403 | PubTator, text mining | PubMed |
| Protocatechualdehyde-functionalized BMSC-derived exosomes orchestrate calcium signaling in the immunoinflammatory microenvironment to promote periodontal regeneration. | J Nanobiotechnology | 2026 | 41794751 | PubTator, text mining | PubMed |
| Child Neurology: Multiple Genetic Etiologies Causing Dandy-Walker Variant With Microcephaly, Epilepsy, and Global Developmental Delay. | Neurology | 2026 | 41791021 | PubTator, text mining | PubMed |
| Advances in calcium signalling research for the diagnosis and treatment of depression. | Ann Med | 2026 | 41787814 | PubTator, text mining | PubMed |
1 to 10 of 751
See all 751 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8911
GET https://conductscience.org/api/genes/v1/8911/patents