Gene · 8912
CACNA1H: calcium voltage-gated channel subunit alpha1 H
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CACNA1H: calcium voltage-gated channel subunit alpha1 H. Genes, record 8912. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8912
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95180 | Voltage-dependent T-type calcium channel subunit alpha-1H | 2,353 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 39675 | O95180 | Espacenet |
| US 12516308 B2 | 2026-01-06 | 2439 | O95180 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 875 | O95180 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 5820 | O95180 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 326 | O95180 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 694 | O95180 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 694 | O95180 | Espacenet |
| JP 2025519096 A | 2025-06-24 | 875 | O95180 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 5820 | O95180 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 10818 | O95180 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs21
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ABT-639 | CHEMBL3590674 | Voltage-gated T-type calcium channel alpha-1H subunit blocker | BLOCKER | ChEMBL |
| APINOCALTAMIDE | CHEMBL4217292 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
| ATAGABALIN | CHEMBL593430 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| BEPRIDIL | CHEMBL1008 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| BEPRIDIL HYDROCHLORIDE | CHEMBL1200382 | Voltage-gated calcium channel blocker | BLOCKER | ChEMBL |
| ETHOSUXIMIDE | CHEMBL696 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
| GABAPENTIN | CHEMBL940 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| GABAPENTIN ENACARBIL | CHEMBL1628502 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| IMAGABALIN | CHEMBL2103836 | Voltage-gated calcium channel modulator | MODULATOR | ChEMBL |
| METHSUXIMIDE | CHEMBL697 | Voltage-gated T-type calcium channel blocker | BLOCKER | ChEMBL |
1 to 10 of 21
See all 21 drugsTrials387
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07606638 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07598474 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07429734 | GABAPENTIN | PHASE3 | ClinicalTrials.gov | |
| NCT07382921 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07344467 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230197 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07230171 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07208357 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07196657 | PREGABALIN | ClinicalTrials.gov | ||
| NCT07186751 | PREGABALIN | ClinicalTrials.gov |
1 to 10 of 387
See all 387 trialsNIH grants1,049
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CACNA1H papers | Newest fiscal year |
|---|---|---|---|
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 10 | 2025 |
| R35GM141802 | Voltage-gated calcium channels as target for anesthetics | 7 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 5 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| R01DK120759 | Role of interstitial cells of Cajal in patterned colonic motor activity | 4 | 2025 |
| R01GM123746 | Novel neurosteroid anesthetics and perioperative analgesia | 4 | 2025 |
| R01NS031348 | Genetic Determinants of Epilepsy in Murine Systems | 4 | 2025 |
| I01BX004763 | T-type Calcium Channel Inhibitors and Alpha Lipoic Acid as Novel Therapies for Treating Pain Post-surgery | 3 | 2025 |
| P30CA044579 | University of Virginia Cancer Center Support Grant | 3 | 2025 |
1 to 10 of 1,049Source NIH's project files
See all 1,049 nih grantsPapers1,764
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis. | Ecotoxicol Environ Saf | 2026 | 42801897 | PubTator, text mining | PubMed |
| Targeting Lung Cancer Stem Cells with Trimebutine: Synergistic Antitumor Activity in Combination with Cisplatin. | Int J Mol Sci | 2026 | 42794641 | PubTator, text mining | PubMed |
| Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults. | Environ Epigenet | 2026 | 42698993 | PubTator, text mining | PubMed |
| The expanding role of Cav3 channels in glioblastoma. | Trends Pharmacol Sci | 2026 | 42697770 | PubTator, text mining | PubMed |
| Primary aldosteronism with intellectual disability associated with CACNA1H and PPP2R5D mutations: a case report with review of literature. | Endocr J | 2026 | 42649046 | PubTator, text mining | PubMed |
| Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis. | Eur Arch Psychiatry Clin Neurosci | 2026 | 42640306 | PubTator, text mining | PubMed |
| Rare germline variants in canonical and candidate genes in apparently sporadic bilateral primary aldosteronism. | J Endocr Soc | 2026 | 42577001 | PubTator, text mining | PubMed |
| Triggered Calcium Lightning Programs Cochlear Development. | Exploration (Beijing) | 2026 | 42517088 | PubTator, text mining | PubMed |
| Temperature-dependent functional inversion of Cav3.2 channels during repetitive activity. | Mol Brain | 2026 | 42421055 | PubTator, text mining | PubMed |
| Chromatin topology control by a muscle-specific ribosomal protein. | bioRxiv | 2026 | 42395400 | PubTator, text mining | PubMed |
1 to 10 of 1,764
See all 1,764 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8912
GET https://conductscience.org/api/genes/v1/8912/patents?page=2