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Gene · 8912

CACNA1H: calcium voltage-gated channel subunit alpha1 H

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA1H: calcium voltage-gated channel subunit alpha1 H. Genes, record 8912. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8912

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Gene

Symbol
CACNA1H
HGNC
Name
calcium voltage-gated channel subunit alpha1 H
HGNC
NCBI Gene ID
8912
NCBI Gene
HGNC ID
HGNC:1395
HGNC
Ensembl
ENSG00000196557
NCBI Gene
Aliases
CACNA1HB, Cav3.2, ECA6, EIG6, HALD4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95180Voltage-dependent T-type calcium channel subunit alpha-1H2,3535Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1439675O95180Espacenet
US 12516308 B22026-01-062439O95180Espacenet
EP 4640849 A22025-10-29875O95180Espacenet
EP 4641201 A22025-10-295820O95180Espacenet
EP 4641202 A22025-10-29326O95180Espacenet
JP 2025529142 A2025-09-04694O95180Espacenet
US 12371689 B22025-07-29694O95180Espacenet
JP 2025519096 A2025-06-24875O95180Espacenet
JP 2025517969 A2025-06-125820O95180Espacenet
JP 2025062604 A2025-04-1410818O95180Espacenet

1 to 10 of 29

See all 29 patents

Drugs21

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ABT-639CHEMBL3590674Voltage-gated T-type calcium channel alpha-1H subunit blockerBLOCKERChEMBL
APINOCALTAMIDECHEMBL4217292Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
ETHOSUXIMIDECHEMBL696Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
METHSUXIMIDECHEMBL697Voltage-gated T-type calcium channel blockerBLOCKERChEMBL

1 to 10 of 21

See all 21 drugs

Trials387

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,049

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1H papersNewest fiscal year
U54GM115428Mississippi Center for Clinical and Translational Research102025
R35GM141802Voltage-gated calcium channels as target for anesthetics72025
UL1TR001863Yale Clinical and Translational Science Award52025
P30CA012197Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
R01DK120759Role of interstitial cells of Cajal in patterned colonic motor activity42025
R01GM123746Novel neurosteroid anesthetics and perioperative analgesia42025
R01NS031348Genetic Determinants of Epilepsy in Murine Systems42025
I01BX004763T-type Calcium Channel Inhibitors and Alpha Lipoic Acid as Novel Therapies for Treating Pain Post-surgery32025
P30CA044579University of Virginia Cancer Center Support Grant32025

1 to 10 of 1,049Source NIH's project files

See all 1,049 nih grants

Papers1,764

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis.Ecotoxicol Environ Saf202642801897PubTator, text miningPubMed
Targeting Lung Cancer Stem Cells with Trimebutine: Synergistic Antitumor Activity in Combination with Cisplatin.Int J Mol Sci202642794641PubTator, text miningPubMed
Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environ Epigenet202642698993PubTator, text miningPubMed
The expanding role of Cav3 channels in glioblastoma.Trends Pharmacol Sci202642697770PubTator, text miningPubMed
Primary aldosteronism with intellectual disability associated with CACNA1H and PPP2R5D mutations: a case report with review of literature.Endocr J202642649046PubTator, text miningPubMed
Exploring sex differences in endocannabinoid system biomarkers and their relationship with antidepressant treatment outcomes in major depressive disorder: a CAN-BIND 1 secondary analysis.Eur Arch Psychiatry Clin Neurosci202642640306PubTator, text miningPubMed
Rare germline variants in canonical and candidate genes in apparently sporadic bilateral primary aldosteronism.J Endocr Soc202642577001PubTator, text miningPubMed
Triggered Calcium Lightning Programs Cochlear Development.Exploration (Beijing)202642517088PubTator, text miningPubMed
Temperature-dependent functional inversion of Cav3.2 channels during repetitive activity.Mol Brain202642421055PubTator, text miningPubMed
Chromatin topology control by a muscle-specific ribosomal protein.bioRxiv202642395400PubTator, text miningPubMed

1 to 10 of 1,764

See all 1,764 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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