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Gene · 8913

CACNA1G: calcium voltage-gated channel subunit alpha1 G

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CACNA1G: calcium voltage-gated channel subunit alpha1 G. Genes, record 8913. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8913

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Gene

Symbol
CACNA1G
HGNC
Name
calcium voltage-gated channel subunit alpha1 G
HGNC
NCBI Gene ID
8913
NCBI Gene
HGNC ID
HGNC:1394
HGNC
Ensembl
ENSG00000006283
NCBI Gene
Aliases
Ca(V)T.1, Cav3.1, NBR13, SCA42, SCA42ND
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O43497Voltage-dependent T-type calcium channel subunit alpha-1G2,3772Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-297657O43497Espacenet
JP 2025529142 A2025-09-04693O43497Espacenet
US 12371689 B22025-07-29693O43497Espacenet
JP 2025517969 A2025-06-127657O43497Espacenet
JP 2025062604 A2025-04-1410787O43497Espacenet
JP 2025032204 A2025-03-1125537O43497Espacenet
EP 4461818 A22024-11-1325537O43497Espacenet
JP 2023058610 A2023-04-2525537O43497Espacenet
US 11446398 B22022-09-2010787O43497Espacenet
US 11400116 B22022-08-024496O43497Espacenet

1 to 10 of 25

See all 25 patents

Drugs20

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
APINOCALTAMIDECHEMBL4217292Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
ATAGABALINCHEMBL593430Voltage-gated calcium channel modulatorMODULATORChEMBL
BEPRIDILCHEMBL1008Voltage-gated calcium channel blockerBLOCKERChEMBL
BEPRIDIL HYDROCHLORIDECHEMBL1200382Voltage-gated calcium channel blockerBLOCKERChEMBL
ETHOSUXIMIDECHEMBL696Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
GABAPENTINCHEMBL940Voltage-gated calcium channel modulatorMODULATORChEMBL
GABAPENTIN ENACARBILCHEMBL1628502Voltage-gated calcium channel modulatorMODULATORChEMBL
IMAGABALINCHEMBL2103836Voltage-gated calcium channel modulatorMODULATORChEMBL
METHSUXIMIDECHEMBL697Voltage-gated T-type calcium channel blockerBLOCKERChEMBL
MIBEFRADILCHEMBL45816Voltage-gated T-type calcium channel blockerBLOCKERChEMBL

1 to 10 of 20

See all 20 drugs

Trials386

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,078

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCACNA1G papersNewest fiscal year
U01CA167552Cancer Epidemiology Cohort in Male Health Professionals152025
UL1TR001863Yale Clinical and Translational Science Award102025
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital92025
R01CA248857Interdisciplinary Epidemiologic Consortium to Investigate T-cell Response in Colorectal Cancer72025
P30CA015704Cancer Center Support Grant62025
R35GM141802Voltage-gated calcium channels as target for anesthetics52025
P30CA008748Cancer Center Support Grant42025
P30CA012197Cancer Center Support Grant42025
R01HL135109Targeting the Arrhythmogenic Sources of Human Atrial Fibrillation42025
R35CA253185Precision Prevention Research Program42025

1 to 10 of 1,078Source NIH's project files

See all 1,078 nih grants

Papers1,769

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Diterpenoid alkaloids from Delphinium aemulans Nevski and their analgesic and ion channel inhibitory activities.Phytochemistry202742710726PubTator, text miningPubMed
Ginsenoside Rg2 inhibits the cell viability of cisplatin-resistant epithelial ovarian cancer by suppressing CACNA1G-mediated calcium signaling.Toxicol Appl Pharmacol202642727823PubTator, text miningPubMed
Ion-Channel Activity of Characteristic Alkaloids From Uncaria rhynchophylla.Chem Biodivers202642720106PubTator, text miningPubMed
The expanding role of Cav3 channels in glioblastoma.Trends Pharmacol Sci202642697770PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
A novel de novo CACNA1G variant p.(Arg1553Gln) associated with neurodevelopmental delay and cerebellar hypoplasia: Expanding the phenotypic spectrum.Eur J Med Genet202642309484PubTator, text miningPubMed
Molecular Pharmacology of T-Type Calcium Channels and Their Roles in Neurological Disorders.Med Res Rev202642272247PubTator, text miningPubMed
Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate.Eur Heart J202642178147PubTator, text miningPubMed
The four voltage-sensing domains of T-type calcium channels activate near the resting membrane potential.Nat Commun202642143043PubTator, text miningPubMed
Novel Truncating Variant c.1222DupC in RBM20 Causes Cardiomyopathy Consistent With Haploinsufficiency.Circ Genom Precis Med202642059065PubTator, text miningPubMed

1 to 10 of 1,769

See all 1,769 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8913

GET https://conductscience.org/api/genes/v1/8913/patents?page=2