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HERC2: HECT and RLD domain containing E3 ubiquitin protein ligase 2
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Gene · 8924

Papers1,281

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 1,281

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TitleJournalYearPMIDFound bySource
Genetic analysis of 22 pigmentation-associated SNPs in the Pashtun population of Khyber Pakhtunkhwa, Pakistan: Implications for forensic DNA phenotyping.Leg Med (Tokyo)202642800203PubTator, text miningPubMed
Aberrant PCM1 accumulation in Trisomy 21 mislocalizes E3 ligases, delaying primary ciliogenesis.bioRxiv202642779918PubTator, text miningPubMed
Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology.Sleep Med202642607587PubTator, text miningPubMed
SUV39H2-mediated NCOA4 methylation controls ferritinophagy and ferroptosis in triple-negative breast cancer.Cell Death Dis202642463647PubTator, text miningPubMed
Case study of monozygotic triplets with identical pineal cysts. Is pineal cyst hereditary condition?Acta Neurochir (Wien)202642340433PubTator, text miningPubMed
HERC2 as a bidirectional iron metabolism switch: Synergistic NCOA4 stabilization and FBXL5 degradation drive ferroptosis-cascaded hepatotoxicity in Nd2O3 nanoparticles exposure.Free Radic Biol Med202642320848PubTator, text miningPubMed
Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations.bioRxiv202642239206PubTator, text miningPubMed
Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer.Clin Genitourin Cancer202642236361PubTator, text miningPubMed
Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells.Cell Death Dis202642071007PubTator, text miningPubMed
The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians.Proc Natl Acad Sci U S A202642008668PubTator, text miningPubMed
Proteasome dysfunction underlies HERC2-linked neurodevelopmental disorder with Angelman-like clinical features.Cell Death Discov202641951624PubTator, text miningPubMed
Targeting Ferroptosis With Natural Products for the Treatment of Skeletal System Disease: An Updated Review.J Cell Mol Med202641928432PubTator, text miningPubMed
Haplotype-Based Analysis of OCA2 Variants in Oculocutaneous Albinism.Pigment Cell Melanoma Res202641905947PubTator, text miningPubMed
Performance of the ForenSeqTM Imagen Kit for Forensic DNA Phenotyping Under Partial Genotyping Conditions.Genes (Basel)202641898888PubTator, text miningPubMed
Genetic analysis of iris pigmentation in Swiss pig breeds identifies a missense KITLG variant as a potential causal factor for pale and heterochromatic irises.Genet Sel Evol202641882519PubTator, text miningPubMed
A comparative GWAS of eye colour in light and dark eye genetic backgrounds defined by HERC2 rs12913832 polymorphism in a Canadian cohort of European ancestry.Sci Rep202641872255PubTator, text miningPubMed
Targeting ubiquitin signaling vulnerabilities in KEAP1-inactivated lung cancer.EMBO J202641862643PubTator, text miningPubMed
Skin Melanin Content and the Foveal Avascular Zone Correlation in a Healthy White Population.Invest Ophthalmol Vis Sci202641848363PubTator, text miningPubMed
Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches.Mol Biomed202641772328PubTator, text miningPubMed
Detection of germline variants in human population chronically exposed to high level natural background radiation in Kerala coast.Genes Environ202641761368PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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