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Gene · 8924

HERC2: HECT and RLD domain containing E3 ubiquitin protein ligase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HERC2: HECT and RLD domain containing E3 ubiquitin protein ligase 2. Genes, record 8924. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8924

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Gene

Symbol
HERC2
HGNC
Name
HECT and RLD domain containing E3 ubiquitin protein ligase 2
HGNC
NCBI Gene ID
8924
NCBI Gene
HGNC ID
HGNC:4868
HGNC
Ensembl
ENSG00000128731
NCBI Gene
Aliases
D15F37S1, MRT38, SHEP1, jdf2, p528
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95714E3 ubiquitin-protein ligase HERC24,83415Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4805378 A12026-09-16101O95714Espacenet
JP 2026523341 A2026-07-14560O95714Espacenet
EP 4771137 A12026-07-0898O95714Espacenet
EP 4771157 A12026-07-0898O95714Espacenet
US 12649003 B22026-06-09560O95714Espacenet
JP 2026510339 A2026-04-0298O95714Espacenet
EP 4713451 A22026-03-2598O95714Espacenet
EP 4713452 A22026-03-2598O95714Espacenet
US 12558437 B22026-02-24560O95714Espacenet
EP 4677082 A22026-01-1498O95714Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants987

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHERC2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant82025
P30ES010126UNC Center for Environmental Health and Susceptibility72025
P30CA016086Cancer Center Support Grant62025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control52025
R01HG002385Long-read sequence and assembly of segmental duplications52025
K24AR069760Patient oriented research and mentoring program in dermatologic diseases42025
P30CA016058Cancer Center Support Grant42025
P30CA023108Cancer Center Support Grant42025
R01CA241623The Role of Genetic Risk Factors in Keratinocyte Carcinoma Susceptibility42025

1 to 10 of 987Source NIH's project files

See all 987 nih grants

Papers1,281

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic analysis of 22 pigmentation-associated SNPs in the Pashtun population of Khyber Pakhtunkhwa, Pakistan: Implications for forensic DNA phenotyping.Leg Med (Tokyo)202642800203PubTator, text miningPubMed
Aberrant PCM1 accumulation in Trisomy 21 mislocalizes E3 ligases, delaying primary ciliogenesis.bioRxiv202642779918PubTator, text miningPubMed
Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology.Sleep Med202642607587PubTator, text miningPubMed
SUV39H2-mediated NCOA4 methylation controls ferritinophagy and ferroptosis in triple-negative breast cancer.Cell Death Dis202642463647PubTator, text miningPubMed
Case study of monozygotic triplets with identical pineal cysts. Is pineal cyst hereditary condition?Acta Neurochir (Wien)202642340433PubTator, text miningPubMed
HERC2 as a bidirectional iron metabolism switch: Synergistic NCOA4 stabilization and FBXL5 degradation drive ferroptosis-cascaded hepatotoxicity in Nd2O3 nanoparticles exposure.Free Radic Biol Med202642320848PubTator, text miningPubMed
Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations.bioRxiv202642239206PubTator, text miningPubMed
Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer.Clin Genitourin Cancer202642236361PubTator, text miningPubMed
Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells.Cell Death Dis202642071007PubTator, text miningPubMed
The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians.Proc Natl Acad Sci U S A202642008668PubTator, text miningPubMed

1 to 10 of 1,281

See all 1,281 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8924

GET https://conductscience.org/api/genes/v1/8924/patents?page=2