Gene · 8924
HERC2: HECT and RLD domain containing E3 ubiquitin protein ligase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. HERC2: HECT and RLD domain containing E3 ubiquitin protein ligase 2. Genes, record 8924. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8924
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95714 | E3 ubiquitin-protein ligase HERC2 | 4,834 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents49
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4805378 A1 | 2026-09-16 | 101 | O95714 | Espacenet |
| JP 2026523341 A | 2026-07-14 | 560 | O95714 | Espacenet |
| EP 4771137 A1 | 2026-07-08 | 98 | O95714 | Espacenet |
| EP 4771157 A1 | 2026-07-08 | 98 | O95714 | Espacenet |
| US 12649003 B2 | 2026-06-09 | 560 | O95714 | Espacenet |
| JP 2026510339 A | 2026-04-02 | 98 | O95714 | Espacenet |
| EP 4713451 A2 | 2026-03-25 | 98 | O95714 | Espacenet |
| EP 4713452 A2 | 2026-03-25 | 98 | O95714 | Espacenet |
| US 12558437 B2 | 2026-02-24 | 560 | O95714 | Espacenet |
| EP 4677082 A2 | 2026-01-14 | 98 | O95714 | Espacenet |
1 to 10 of 49
See all 49 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants987
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | HERC2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 8 | 2025 |
| P30ES010126 | UNC Center for Environmental Health and Susceptibility | 7 | 2025 |
| P30CA016086 | Cancer Center Support Grant | 6 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 5 | 2025 |
| R01HG002385 | Long-read sequence and assembly of segmental duplications | 5 | 2025 |
| K24AR069760 | Patient oriented research and mentoring program in dermatologic diseases | 4 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 4 | 2025 |
| P30CA023108 | Cancer Center Support Grant | 4 | 2025 |
| R01CA241623 | The Role of Genetic Risk Factors in Keratinocyte Carcinoma Susceptibility | 4 | 2025 |
1 to 10 of 987Source NIH's project files
See all 987 nih grantsPapers1,281
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Genetic analysis of 22 pigmentation-associated SNPs in the Pashtun population of Khyber Pakhtunkhwa, Pakistan: Implications for forensic DNA phenotyping. | Leg Med (Tokyo) | 2026 | 42800203 | PubTator, text mining | PubMed |
| Aberrant PCM1 accumulation in Trisomy 21 mislocalizes E3 ligases, delaying primary ciliogenesis. | bioRxiv | 2026 | 42779918 | PubTator, text mining | PubMed |
| Sleep disruption and neuropsychiatric features in Angelman syndrome: insights into underlying neurobiology. | Sleep Med | 2026 | 42607587 | PubTator, text mining | PubMed |
| SUV39H2-mediated NCOA4 methylation controls ferritinophagy and ferroptosis in triple-negative breast cancer. | Cell Death Dis | 2026 | 42463647 | PubTator, text mining | PubMed |
| Case study of monozygotic triplets with identical pineal cysts. Is pineal cyst hereditary condition? | Acta Neurochir (Wien) | 2026 | 42340433 | PubTator, text mining | PubMed |
| HERC2 as a bidirectional iron metabolism switch: Synergistic NCOA4 stabilization and FBXL5 degradation drive ferroptosis-cascaded hepatotoxicity in Nd2O3 nanoparticles exposure. | Free Radic Biol Med | 2026 | 42320848 | PubTator, text mining | PubMed |
| Fast pairwise coalescence enables gene-resolution scans for recent selection in diverse human populations. | bioRxiv | 2026 | 42239206 | PubTator, text mining | PubMed |
| Epidemiological Trends and Germline Variant Analysis of Young-Onset Bladder Cancer. | Clin Genitourin Cancer | 2026 | 42236361 | PubTator, text mining | PubMed |
| Ubiquitination of DDX21 by HERC2 induces a dormancy-like phenotype via the NUCKS1-p21/p27 axis to promote radio-resistance in colorectal cancer cells. | Cell Death Dis | 2026 | 42071007 | PubTator, text mining | PubMed |
| The persistence and loss of hard selective sweeps amid admixture in ancient Eurasians. | Proc Natl Acad Sci U S A | 2026 | 42008668 | PubTator, text mining | PubMed |
1 to 10 of 1,281
See all 1,281 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8924
GET https://conductscience.org/api/genes/v1/8924/patents?page=2