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Gene · 8929

PHOX2B: paired like homeobox 2B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. PHOX2B: paired like homeobox 2B. Genes, record 8929. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8929

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Gene

Symbol
PHOX2B
HGNC
Name
paired like homeobox 2B
HGNC
NCBI Gene ID
8929
NCBI Gene
HGNC ID
HGNC:9143
HGNC
Ensembl
ENSG00000109132
NCBI Gene
Aliases
CCHS, NBLST2, NBPhox, PMX2B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99453Paired mesoderm homeobox protein 2B3145Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456918Q99453Espacenet
EP 4641201 A22025-10-29464Q99453Espacenet
JP 2025147176 A2025-10-0615487Q99453Espacenet
JP 2025517969 A2025-06-12464Q99453Espacenet
JP 2025028160 A2025-02-2815487Q99453Espacenet
KR 1020250010750 A2025-01-2115487Q99453Espacenet
JP 2024532258 A2024-09-052Q99453Espacenet
JP 2024109657 A2024-08-1415326Q99453Espacenet
EP 4392047 A22024-07-032Q99453Espacenet
KR 1020240051183 A2024-04-192Q99453Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,025

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitlePHOX2B papersNewest fiscal year
P30CA008748Cancer Center Support Grant132025
P01CA217959Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance102025
P30CA021765Cancer Center Support Grant (CCSG)102025
R35CA220500Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomes92025
R01HL108609Cellular/Molecular Mechanisms of Respiratory Neuronal Chemosensitivity62025
T32CA128583Research Training in Childhood Cancer52025
P30CA016672Cancer Center Support Grant42025
R35GM125034An integrative structural biology approach to understanding metabolite recognition by cellular receptors42025
U10CA180886COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement42025
ZIABC010998Therapy Resistance Mechanisms for Cancer42025

1 to 10 of 1,025Source NIH's project files

See all 1,025 nih grants

Papers1,813

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
TCF4 at the crest of development: a zebrafish model to explore craniofacial and gastrointestinal defects in Pitt-Hopkins syndrome.Front Cell Dev Biol202642761059PubTator, text miningPubMed
[Single-center application and analysis of neuroblastoma marker detection in childhood neuroblastoma].Zhongguo Dang Dai Er Ke Za Zhi202642751903PubTator, text miningPubMed
Unmasking phenotypic heterogeneity and extracellular matrix architecture in neuroblastoma through orthotopic xenograft modeling.Transl Oncol202642731416PubTator, text miningPubMed
Microbiota-Metabolome Alterations Suggest Pro-Inflammatory Phenotype in Congenital Central Hypoventilation Syndrome.Int J Microbiol202642712877PubTator, text miningPubMed
Negative Pressure Ventilation via Biphasic Cuirass Device in an Adolescent With Congenital Central Hypoventilation Syndrome Undergoing Septorhinoplasty: A Case Report.Cureus202642639454PubTator, text miningPubMed
Population-based genomic detection of childhood cancer predisposition using newborn dried blood spots.Nat Commun202642586985PubTator, text miningPubMed
PHOX2B polyalanine repeat mutation alters the transcriptome of neuronal progenitor cells in congenital central hypoventilation syndrome.Neurobiol Dis202642480943PubTator, text miningPubMed
New Neuroendocrine Markers PITX2, PHOX2B, and HAND2 Do Not Offer Diagnostic Utility in Fine-needle Aspiration Biopsies of Primary and Secondary Medullary Thyroid Carcinomas: A Retrospective Multi-institutional Study.
J Clin Transl Pathol202642433465PubTator, text miningPubMed
CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes.Front Physiol202642422362PubTator, text miningPubMed
Lung Carcinoids with Sustentacular Cells and Low Keratin Expression: A Common yet Underrecognized Phenomenon with Diagnostic and Biological Implications.Mod Pathol202642401207PubTator, text miningPubMed

1 to 10 of 1,813

See all 1,813 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8929

GET https://conductscience.org/api/genes/v1/8929/patents?page=2