Gene · 8929
PHOX2B: paired like homeobox 2B
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. PHOX2B: paired like homeobox 2B. Genes, record 8929. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8929
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99453 | Paired mesoderm homeobox protein 2B | 314 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 56918 | Q99453 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 464 | Q99453 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15487 | Q99453 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 464 | Q99453 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15487 | Q99453 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15487 | Q99453 | Espacenet |
| JP 2024532258 A | 2024-09-05 | 2 | Q99453 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15326 | Q99453 | Espacenet |
| EP 4392047 A2 | 2024-07-03 | 2 | Q99453 | Espacenet |
| KR 1020240051183 A | 2024-04-19 | 2 | Q99453 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,025
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | PHOX2B papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 13 | 2025 |
| P01CA217959 | Discovering and Exploiting Mechanisms of Neuroblastoma Therapy Resistance | 10 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 10 | 2025 |
| R35CA220500 | Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomes | 9 | 2025 |
| R01HL108609 | Cellular/Molecular Mechanisms of Respiratory Neuronal Chemosensitivity | 6 | 2025 |
| T32CA128583 | Research Training in Childhood Cancer | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| R35GM125034 | An integrative structural biology approach to understanding metabolite recognition by cellular receptors | 4 | 2025 |
| U10CA180886 | COG NCTN Network Group Operations Center - Year 11 STAR Act MCI and PEC Supplement | 4 | 2025 |
| ZIABC010998 | Therapy Resistance Mechanisms for Cancer | 4 | 2025 |
1 to 10 of 1,025Source NIH's project files
See all 1,025 nih grantsPapers1,813
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| TCF4 at the crest of development: a zebrafish model to explore craniofacial and gastrointestinal defects in Pitt-Hopkins syndrome. | Front Cell Dev Biol | 2026 | 42761059 | PubTator, text mining | PubMed |
| [Single-center application and analysis of neuroblastoma marker detection in childhood neuroblastoma]. | Zhongguo Dang Dai Er Ke Za Zhi | 2026 | 42751903 | PubTator, text mining | PubMed |
| Unmasking phenotypic heterogeneity and extracellular matrix architecture in neuroblastoma through orthotopic xenograft modeling. | Transl Oncol | 2026 | 42731416 | PubTator, text mining | PubMed |
| Microbiota-Metabolome Alterations Suggest Pro-Inflammatory Phenotype in Congenital Central Hypoventilation Syndrome. | Int J Microbiol | 2026 | 42712877 | PubTator, text mining | PubMed |
| Negative Pressure Ventilation via Biphasic Cuirass Device in an Adolescent With Congenital Central Hypoventilation Syndrome Undergoing Septorhinoplasty: A Case Report. | Cureus | 2026 | 42639454 | PubTator, text mining | PubMed |
| Population-based genomic detection of childhood cancer predisposition using newborn dried blood spots. | Nat Commun | 2026 | 42586985 | PubTator, text mining | PubMed |
| PHOX2B polyalanine repeat mutation alters the transcriptome of neuronal progenitor cells in congenital central hypoventilation syndrome. | Neurobiol Dis | 2026 | 42480943 | PubTator, text mining | PubMed |
New Neuroendocrine Markers PITX2, PHOX2B, and HAND2 Do Not Offer Diagnostic Utility in Fine-needle Aspiration Biopsies of Primary and Secondary Medullary Thyroid Carcinomas: A Retrospective Multi-institutional Study. | J Clin Transl Pathol | 2026 | 42433465 | PubTator, text mining | PubMed |
| CRISPR/Cas9-mediated PHOX2B functional knock-out in IMR32 neuroblastoma cells impairs neuronal excitability through dysregulation of ion channels genes. | Front Physiol | 2026 | 42422362 | PubTator, text mining | PubMed |
| Lung Carcinoids with Sustentacular Cells and Low Keratin Expression: A Common yet Underrecognized Phenomenon with Diagnostic and Biological Implications. | Mod Pathol | 2026 | 42401207 | PubTator, text mining | PubMed |
1 to 10 of 1,813
See all 1,813 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/8929
GET https://conductscience.org/api/genes/v1/8929/patents?page=2