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Gene · 8930

MBD4: methyl-CpG binding domain 4, DNA glycosylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MBD4: methyl-CpG binding domain 4, DNA glycosylase. Genes, record 8930. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8930

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Gene

Symbol
MBD4
HGNC
Name
methyl-CpG binding domain 4, DNA glycosylase
HGNC
NCBI Gene ID
8930
NCBI Gene
HGNC ID
HGNC:6919
HGNC
Ensembl
ENSG00000129071
NCBI Gene
Aliases
MED1, TPDS2, UVM1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95243Methyl-CpG-binding domain protein 458018Ensembl, GeneID, HGNC

Source UniProt

Patents67

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-123871O95243Espacenet
US 12624354 B22026-05-123871O95243Espacenet
US 12570972 B22026-03-103871O95243Espacenet
US 12509680 B22025-12-303871O95243Espacenet
EP 4650780 A22025-11-191292O95243Espacenet
EP 4640849 A22025-10-29146O95243Espacenet
EP 4641201 A22025-10-29921O95243Espacenet
JP 2025147176 A2025-10-0615269O95243Espacenet
JP 2025519096 A2025-06-24146O95243Espacenet
JP 2025517969 A2025-06-12921O95243Espacenet

1 to 10 of 67

See all 67 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,048

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMBD4 papersNewest fiscal year
P30CA006927Comprehensive Cancer Center Program at Fox Chase142025
P30CA008748Cancer Center Support Grant62025
P30CA016059Massey Cancer Center - Cancer Center Support Grant52025
P01CA092584Structural Cell Biology of DNA Repair Machines42025
P30CA047904Cancer Center Support Grant42025
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)42025
R01DK071865Molecular Mechanisms of Active Copper Transport42025
ZIACP010121Molecular Epidemiology Studies of Occupational and Environmental Exposures42025
P01AG047200Comparative genomics of longevity and Alzheimer's disease32025
P30CA013330Cancer Center Support Grant32025

1 to 10 of 1,048Source NIH's project files

See all 1,048 nih grants

Papers1,380

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Survival of Patients With MBD4-Mutated Metastatic Uveal Melanoma Treated With Immune Checkpoint Inhibitors.Transl Vis Sci Technol202642788773PubTator, text miningPubMed
Prognostic significance of DNA damage response-related markers in esophageal squamous cell carcinoma using machine learning approaches.J Gastrointest Oncol202642703410PubTator, text miningPubMed
Human PMS1-dependent non-canonical mismatch repair engages with MBD4 to repair methylated CpG deamination.Nucleic Acids Res202642578366PubTator, text miningPubMed
Impact of Multigene Panel Testing in High-Risk Uveal Melanoma Patients.Pigment Cell Melanoma Res202642415513PubTator, text miningPubMed
Hereditary Cancer Genetic Testing for All? A Retrospective Analysis on Genetic Mutations Found in Individuals Not Meeting NCCN® Guidelines.Eur J Breast Health202642317085PubTator, text miningPubMed
Mapping DNA glycosylase binding across lesion sequence contexts reveals extended sequence and structural recognition logic.Nat Commun202642251035PubTator, text miningPubMed
Biallelic germline MBD4 mutations predispose to colorectal polyposis, hypermutated AML, and schwannomas.Fam Cancer202642101541PubTator, text miningPubMed
Germline haploinsufficiency of MUTYH causes mutational signature SBS18 in multiple tumour types and specifically raises colorectal cancer risk.NPJ Precis Oncol202642092060PubTator, text miningPubMed
Prevalence of the Predisposing Gene MBD4 for Uveal Melanoma.JAMA Ophthalmol202642060275PubTator, text miningPubMed
Genome Sequencing of Undiagnosed European Patients Suspected of Hereditary Cancer: Diagnostic Yield and Identification of Candidate Causative Variants.JCO Precis Oncol202641990296PubTator, text miningPubMed

1 to 10 of 1,380

See all 1,380 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8930

GET https://conductscience.org/api/genes/v1/8930/patents?page=2