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Gene · 8932

MBD2: methyl-CpG binding domain protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MBD2: methyl-CpG binding domain protein 2. Genes, record 8932. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8932

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Gene

Symbol
MBD2
HGNC
Name
methyl-CpG binding domain protein 2
HGNC
NCBI Gene ID
8932
NCBI Gene
HGNC ID
HGNC:6917
HGNC
Ensembl
ENSG00000134046
NCBI Gene
Aliases
DMTase, NY-CO-41
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UBB5Methyl-CpG-binding domain protein 241114Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4698657 A22026-02-25385Q9UBB5Espacenet
JP 2026004568 A2026-01-1453374Q9UBB5Espacenet
JP 2025147176 A2025-10-0615265Q9UBB5Espacenet
JP 2025509420 A2025-04-115Q9UBB5Espacenet
JP 2025028160 A2025-02-2815265Q9UBB5Espacenet
EP 4493713 A22025-01-225Q9UBB5Espacenet
KR 1020250010750 A2025-01-2115265Q9UBB5Espacenet
JP 2024109657 A2024-08-1415104Q9UBB5Espacenet
US 11920164 B22024-03-056Q9UBB5Espacenet
US 11446398 B22022-09-2050861Q9UBB5Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,946

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMBD2 papersNewest fiscal year
P30CA016672Cancer Center Support Grant142025
P30CA016058Cancer Center Support Grant122025
P30CA016059Massey Cancer Center - Cancer Center Support Grant122025
P30CA006973Regional Oncology Research Center92025
ZIAES101965Eukaryotic Transcriptional Regulation92025
P30CA022453CANCER CENTER SUPPORT GRANT82025
R01DK115563The Role of the MBD2-NuRD Complex in Gamma-Globin Gene Silencing72025
P30CA016086Cancer Center Support Grant62025
P30ES013508Center of Excellence in Environmental Toxicology62025
P30CA008748Cancer Center Support Grant52025

1 to 10 of 1,946Source NIH's project files

See all 1,946 nih grants

Papers2,613

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
Structure-guided targeting of the GATAD2A-CHD4 interaction within the MBD2-NuRD complex results in high levels of HbF in adult erythroid cells.bioRxiv202642539289PubTator, text miningPubMed
Histone Methylation and Chromatin Remodeling in Non-Small Cell Lung Cancer: Mechanisms of Oncogenesis and Emerging Therapeutic Strategies.Biomedicines202642512002PubTator, text miningPubMed
HBx-Associated Reactivation of the IGF2 Locus in Chronic HBV Infection and HBV-Related Hepatocarcinogenesis: Evidence Boundaries and Biomarker Implications.Biomedicines202642511915PubTator, text miningPubMed
Exercise, Demethylase FTO, Neurological Disorders, and Neuropathic Pain: Potential Molecular Mechanisms.CNS Neurosci Ther202642504920PubTator, text miningPubMed
Targeted Transcriptional Repression by Induced Proximity.ACS Cent Sci202642500035PubTator, text miningPubMed
Overcoming Therapeutic Resistance in Head and Neck Squamous Cell Carcinoma (HNSCC): The Role of Histone Methyltransferase and Demethylase Inhibitors.Cancers (Basel)202642449712PubTator, text miningPubMed
Development of a prognostic prediction model incorporating KDM1B for esophageal squamous cell carcinoma: an integrated transcriptomic and functional analysis.J Gastrointest Oncol202642434278PubTator, text miningPubMed
A potent small-chemical MBD2 inhibitor, KCC-07, induces selective cytotoxicity in hepatocellular and prostate cancer cells.Mol Biol Rep202642429995PubTator, text miningPubMed
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.J Cardiovasc Aging202642369572PubTator, text miningPubMed

1 to 10 of 2,613

See all 2,613 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8932

GET https://conductscience.org/api/genes/v1/8932/patents?page=2