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BTRC: beta-transducin repeat containing E3 ubiquitin protein ligase

1 protein, 28 patents, 0 drugs, 0 trials, 3,004 NIH grants and 4,722 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolBTRCHGNC
Namebeta-transducin repeat containing E3 ubiquitin protein ligaseHGNC
NCBI Gene ID8945NCBI Gene
HGNC IDHGNC:1144HGNC
EnsemblENSG00000166167NCBI Gene
AliasesBETA-TRCP, FBW1A, FBXW1, FBXW1A, FWD1, Fwd1, bTrCP, bTrCP1, beta-TrCP1, betaTrCPNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9Y297F-box/WD repeat-containing protein 1A60515Ensembl, GeneID, HGNCUniProt

Patents 28

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026507518 A2026-03-04155Q9Y297Espacenet
JP 2026004568 A2026-01-1438991Q9Y297Espacenet
EP 4665771 A12025-12-24155Q9Y297Espacenet
EP 4650780 A22025-11-198739Q9Y297Espacenet
JP 2025517970 A2025-06-128739Q9Y297Espacenet
JP 2025062604 A2025-04-149070Q9Y297Espacenet
US 11446398 B22022-09-209070Q9Y297Espacenet
JP 2022537339 A2022-08-25119Q9Y297Espacenet
JP 2022524081 A2022-04-27112041Q9Y297Espacenet
KR 1020200053864 A2020-05-194Q9Y297Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3004

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant472,025NIH's project files
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control182,025NIH's project files
P30CA008748Cancer Center Support Grant132,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center132,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028112,025NIH's project files
P30CA016087Cancer Center Support Grant102,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant82,025NIH's project files
R35CA197589Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities82,025NIH's project files
P30CA016058Cancer Center Support Grant72,025NIH's project files
P30CA016086Cancer Center Support Grant72,025NIH's project files

Papers 4722

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818268PubTator, text miningPubMed
42716186PubTator, text miningPubMed
42638991PubTator, text miningPubMed
42608541PubTator, text miningPubMed
42575696PubTator, text miningPubMed
42546806PubTator, text miningPubMed
42442361PubTator, text miningPubMed
42432349PubTator, text miningPubMed
42414524PubTator, text miningPubMed
42376209PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license