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Gene · 8976

WASL: WASP like actin nucleation promoting factor

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. WASL: WASP like actin nucleation promoting factor. Genes, record 8976. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/8976

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Gene

Symbol
WASL
HGNC
Name
WASP like actin nucleation promoting factor
HGNC
NCBI Gene ID
8976
NCBI Gene
HGNC ID
HGNC:12735
HGNC
Ensembl
ENSG00000106299
NCBI Gene
Aliases
N-WASP, NWASP, WASPB
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O00401Actin nucleation-promoting factor WASL5058Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-19579O00401Espacenet
EP 4641201 A22025-10-29408O00401Espacenet
JP 2025517969 A2025-06-12408O00401Espacenet
JP 2025517970 A2025-06-12579O00401Espacenet
JP 2024123008 A2024-09-109087O00401Espacenet
US 11446398 B22022-09-2097753O00401Espacenet
JP 2022524081 A2022-04-27200724O00401Espacenet
US 11078247 B22021-08-0312555O00401Espacenet
US 10501513 B22019-12-109087O00401Espacenet
JP 2017197545 A2017-11-0233788O00401Espacenet

1 to 10 of 23

See all 23 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,726

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleWASL papersNewest fiscal year
R01GM073791Structural-Functional Basis of Actin Cytoskeleton Dynamics152025
P30CA013330Cancer Center Support Grant82025
P30CA016672Cancer Center Support Grant82025
P30CA008748Cancer Center Support Grant62025
R35GM118149Actin assembly and clathrin-mediated endocytosis in yeast and mammals62025
ZIACL080017IQGAP1 in tumorigenesis62025
P30CA014051Cancer Center Support (Core) Grant52025
P30DA018343Yale/NIDA Neuroproteomics Center52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
P40OD010440Caenorhabditis Genetics Center52025

1 to 10 of 1,726Source NIH's project files

See all 1,726 nih grants

Papers2,524

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A novel minimally invasive diagnostic approach of various brain malignancies based on differential miRNA expression.J Neurooncol202642809056PubTator, text miningPubMed
miR-185 influences Cdc42-N-WASP signaling pathway in gastric cancer by targeting CTTN.Pak J Pharm Sci202642632930PubTator, text miningPubMed
The Nance-Horan syndrome protein NHS regulates cell migration persistence by organizing WAVE and N-WASP nucleation-promoting factor complexes.J Biol Chem202642595116PubTator, text miningPubMed
Microscale matrix defects suppress tension-dependent protrusions and stall collective cell migration.Cell Rep202642537646PubTator, text miningPubMed
PAK4 in the Tumor Immune Microenvironment: Biological Functions, Regulatory Mechanisms, and Targeted Therapeutic Strategies.Med Res Rev202642489806PubTator, text miningPubMed
The mechanisms of DEPDC7-mediated actin cap establishment and meiosis progression in oocytes.EMBO Rep202642332067PubTator, text miningPubMed
Molecular and functional consequences of the Cdc42 C81Y mutation in immune-associated malignancy.Arch Biochem Biophys202642173300PubTator, text miningPubMed
N-WASP is downregulated in patients with acute myeloid leukemia (AML) and is associated with poor prognosis.Sci Rep202642014831PubTator, text miningPubMed
DYRK1A and Parkinson's disease, facts and hypotheses.Neurobiol Dis202641991085PubTator, text miningPubMed
Dispensable players: N-WASP and WASP are not crucial for homology-directed DNA repair.EMBO Rep202641963733PubTator, text miningPubMed

1 to 10 of 2,524

See all 2,524 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/8976

GET https://conductscience.org/api/genes/v1/8976/patents?page=2