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TRPA1: transient receptor potential cation channel subfamily A member 1

1 protein, 36 patents, 5 drugs, 18 trials, 2,087 NIH grants and 5,042 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolTRPA1HGNC
Nametransient receptor potential cation channel subfamily A member 1HGNC
NCBI Gene ID8989NCBI Gene
HGNC IDHGNC:497HGNC
EnsemblENSG00000104321NCBI Gene
AliasesANKTM1, FEPS, FEPS1, p120NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O75762Transient receptor potential cation channel subfamily A member 11,11917Ensembl, GeneID, HGNCUniProt

Patents 36

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1467587O75762Espacenet
EP 4641201 A22025-10-291597O75762Espacenet
JP 2025529142 A2025-09-045061O75762Espacenet
US 12371689 B22025-07-295061O75762Espacenet
JP 2025517969 A2025-06-121597O75762Espacenet
US 11464720 B22022-10-112O75762Espacenet
US 11446398 B22022-09-2090277O75762Espacenet
US 11400116 B22022-08-023688O75762Espacenet
JP 2022524081 A2022-04-27193248O75762Espacenet
JP 2021165251 A2021-10-146O75762Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BUTAMBENCHEMBL127516Transient receptor potential cation channel subfamily A member 1 inhibitorINHIBITORChEMBL
BUTAMBEN PICRATECHEMBL3142541Transient receptor potential cation channel subfamily A member 1 inhibitorINHIBITORChEMBL
CB-189625CHEMBL3707378Transient receptor potential cation channel subfamily A member 1 antagonistANTAGONISTChEMBL
GRC-17536CHEMBL3707318Transient receptor potential cation channel subfamily A member 1 antagonistANTAGONISTChEMBL
MENTHOLCHEMBL256087Transient receptor potential cation channel subfamily A member 1 openerOPENERChEMBL

Trials 18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07294469MENTHOLPHASE2ClinicalTrials.gov
NCT07109609MENTHOLPHASE2ClinicalTrials.gov
NCT05877079MENTHOLPHASE2ClinicalTrials.gov
NCT05799053MENTHOLPHASE3ClinicalTrials.gov
NCT04900129MENTHOLPHASE1ClinicalTrials.gov
NCT04276727MENTHOLPHASE2ClinicalTrials.gov
NCT04103086MENTHOLClinicalTrials.gov
NCT03243630MENTHOLEARLY_PHASE12020-11-13ClinicalTrials.gov
NCT03095508MENTHOLPHASE32019-03-21ClinicalTrials.gov
NCT02749123MENTHOLClinicalTrials.gov

NIH grants 2087

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01NS070711Nociceptive Mechanisms Underlying Sickle Cell Pain192,025NIH's project files
R01CA206573Structure and function of Transient Receptor Potential Channels72,025NIH's project files
R01DC007864Molecular genetics of gustatory detection72,025NIH's project files
R01GM093290Regulation of the epithelial Ca2+ channels TRPV6 and TRPV572,025NIH's project files
R35NS105038Natural products as probes of the pain pathway62,025NIH's project files
R37NS108278Pain Mechanisms in Fabry Disease62,025NIH's project files
P40OD018537Bloomington Drosophila Stock Center at Indiana University52,025NIH's project files
R01DC000304Molecular Mechanisms of Auditory Transduction52,025NIH's project files
R01NS102722Endosomal Platforms for Signaling Pain52,025NIH's project files
R01NS107253Single-Particle Cryo-EM Characterization of AMPA Receptor Functional States52,025NIH's project files

Papers 5042

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822051PubTator, text miningPubMed
42819782PubTator, text miningPubMed
42811508PubTator, text miningPubMed
42796027PubTator, text miningPubMed
42793248PubTator, text miningPubMed
42784317PubTator, text miningPubMed
42783432PubTator, text miningPubMed
42782815PubTator, text miningPubMed
42780203PubTator, text miningPubMed
42779518PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license