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Gene · 90

ACVR1: activin A receptor type 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACVR1: activin A receptor type 1. Genes, record 90. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/90

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Gene

Symbol
ACVR1
HGNC
Name
activin A receptor type 1
HGNC
NCBI Gene ID
90
NCBI Gene
HGNC ID
HGNC:171
HGNC
Ensembl
ENSG00000115170
NCBI Gene
Aliases
ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q04771Activin receptor type-150985Ensembl, GeneID, HGNC

Source UniProt

Patents173

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026514618 A2026-05-1361Q04771Espacenet
EP 4698654 A12026-02-2525Q04771Espacenet
JP 2026004568 A2026-01-1436225Q04771Espacenet
JP 2026004568 A2026-01-1436226Q04771Espacenet
JP 2026004568 A2026-01-1436227Q04771Espacenet
JP 2026004568 A2026-01-1436231Q04771Espacenet
EP 4650780 A22025-11-192230Q04771Espacenet
JP 2025147176 A2025-10-06194Q04771Espacenet
JP 2025147176 A2025-10-06195Q04771Espacenet
JP 2025147176 A2025-10-06196Q04771Espacenet

1 to 10 of 173

See all 173 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
DIBOTERMIN ALFACHEMBL2109171Activin receptor type-1 agonistAGONISTChEMBL
EPTOTERMIN ALFACHEMBL2108594Activin receptor type-1 agonistAGONISTChEMBL
MOMELOTINIBCHEMBL1078178Activin receptor type-1 inhibitorINHIBITORChEMBL
MOMELOTINIB DIHYDROCHLORIDE MONOHYDRATECHEMBL6068336Activin receptor type-1 inhibitorINHIBITORChEMBL
PACRITINIBCHEMBL2035187Activin receptor type-1 inhibitorINHIBITORChEMBL
PACRITINIB CITRATECHEMBL5095049Activin receptor type-1 inhibitorINHIBITORChEMBL

Trials70

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07569081MOMELOTINIBPHASE2/PHASE3ClinicalTrials.gov
NCT07498205MOMELOTINIBPHASE4ClinicalTrials.gov
NCT07447817PACRITINIBPHASE2ClinicalTrials.gov
NCT07424950MOMELOTINIBPHASE2ClinicalTrials.gov
NCT07394153PACRITINIBPHASE2ClinicalTrials.gov
NCT07387354PACRITINIBPHASE1/PHASE2ClinicalTrials.gov
NCT07226713PACRITINIBPHASE2ClinicalTrials.gov
NCT07148947PACRITINIBPHASE2ClinicalTrials.gov
NCT07104799MOMELOTINIBPHASE1ClinicalTrials.gov
NCT07098936MOMELOTINIBPHASE2ClinicalTrials.gov

1 to 10 of 70

See all 70 trials

NIH grants1,916

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACVR1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant152025
P30CA008748Cancer Center Support Grant132025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN112025
P30AR069619Overall: Resource-based Center for Musculoskeletal Disorders Research (Overall Application)112025
P30CA021765Cancer Center Support Grant (CCSG)102025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center72025
P30CA068485Cancer Center Support Grant62025
P50CA097257Brain Tumor SPORE Grant62025
P30CA054174Mays Cancer Center at UT Health SA52025
R01HL081397Mechanism of Matrix Gla Protein (MGP); Adipose Fibrosis52025

1 to 10 of 1,916Source NIH's project files

See all 1,916 nih grants

Papers2,859

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
High-throughput spheroid profiling reveals BMP-driven rewiring of glioma cell death responses.bioRxiv202642818713PubTator, text miningPubMed
Reassessing the clinical value of momelotinib in myelofibrosis: An ESMO-MCBS:H-based appraisal of SIMPLIFY-1 and MOMENTUM.Crit Rev Oncol Hematol202642800596PubTator, text miningPubMed
Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo.Cells202642782774PubTator, text miningPubMed
PSMD14 as a translational target in cancer and beyond: from deubiquitination mechanisms to drug resistance and precision therapy.Cancer Drug Resist202642729688PubTator, text miningPubMed
Diffuse intrinsic pontine glioma in the era of H3 K27-altered diffuse midline glioma.Crit Rev Oncol Hematol202642692100PubTator, text miningPubMed
Immunogenomic profiling reveals targets for gene therapy in pediatric brain tumors.Neurooncol Adv202642592420PubTator, text miningPubMed
Hepcidin as a Molecular Hub of Iron Homeostasis: From BMP-SMAD Signaling to Therapeutic Modulation.Biomolecules202642509741PubTator, text miningPubMed
Fibrodysplasia Ossificans Progressiva: Clinicoradiological Insights Into a Rare Case.Cureus202642504373PubTator, text miningPubMed
Rare variant analysis of whole genome sequenced juvenile idiopathic arthritis multiplex pedigrees identifies rare variants in NOD2 and ACVR1.G3 (Bethesda)202642466628PubTator, text miningPubMed
A closed-loop cell therapy engineered to autonomously secrete activin A inhibitor protects from fibrodysplasia ossificans progressiva.iScience202642433667PubTator, text miningPubMed

1 to 10 of 2,859

See all 2,859 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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