Gene · 9002
F2RL3: F2R like thrombin or trypsin receptor 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. F2RL3: F2R like thrombin or trypsin receptor 3. Genes, record 9002. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9002
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q96RI0 | Proteinase-activated receptor 4 | 385 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 41712 | Q96RI0 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 1238 | Q96RI0 | Espacenet |
| US 12441790 B2 | 2025-10-14 | 19 | Q96RI0 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 4971 | Q96RI0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 1468 | Q96RI0 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 6312 | Q96RI0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 1468 | Q96RI0 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 6312 | Q96RI0 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 1238 | Q96RI0 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 4971 | Q96RI0 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| BMS-986141 | CHEMBL3716552 | Proteinase activated receptor 4 antagonist | ANTAGONIST |
Source ChEMBL
Trials1
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted |
|---|---|---|---|
| NCT05093790 | BMS-986141 | PHASE2 | 2023-12-05 |
Source ClinicalTrials.gov
NIH grants1,327
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | F2RL3 papers | Newest fiscal year |
|---|---|---|---|
| R01HL049413 | Structural basis of prothrombin activation | 9 | 2025 |
| R01HL101917 | Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases | 7 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30ES009089 | Center for Environmental Health in Northern Manhattan | 6 | 2025 |
| R01HL131517 | Sex-specific arrhythmogenic mechanisms of atrial fibrillation | 6 | 2025 |
| R01HL136389 | The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis | 6 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 6 | 2025 |
| R01HL101972 | Characterization of Coagulation Factor-platelet Interactions: Role of FXI | 5 | 2025 |
| P30AI036219 | Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR) | 4 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 1,327Source NIH's project files
See all 1,327 nih grantsPapers2,206
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Impact of C-terminal amidation on platelet activation by protease-activated receptors 1 and 4 activating peptides: communication from the ISTH SSC Subcommittee on Platelets in Health and Disease. | J Thromb Haemost | 2026 | 42810688 | PubTator, text mining | PubMed |
| Papain reproduces the prothrombin-dependent PAR1/PAR4 signalling mechanism of the house dust mite allergen Der p 1. | Mol Immunol | 2026 | 42727264 | PubTator, text mining | PubMed |
| GPCRs interaction with LGR5: Implications to cancer stemness. | J Cancer | 2026 | 42577862 | PubTator, text mining | PubMed |
| hsa-miR-3529-5p through F2RL3 Regulation as an Enhancer of Sensitivity to Cisplatin. | Indian J Clin Biochem | 2026 | 42500345 | PubTator, text mining | PubMed |
| Characterizing tumor-associated endothelial cells in clear cell renal cell carcinoma via scRNA-seq and Bulk RNA-seq: construction of a prognostic risk signature. | Arch Biochem Biophys | 2026 | 42392347 | PubTator, text mining | PubMed |
| Structural mechanisms for self-activation of protease-activated receptor 4 by tethered ligand. | Cell Rep | 2026 | 42378089 | PubTator, text mining | PubMed |
| Blood DNA Methylation Patterns Across Carotid, Coronary, and Peripheral Atherosclerosis: A Comparative Analysis in 2 Prospective Cohorts. | J Am Coll Cardiol | 2026 | 42233926 | PubTator, text mining | PubMed |
| An EV-Guided Multi-Compartment Proof-of-Concept Framework for Biomarker Prioritization in Cholangiocarcinoma. | Med Sci (Basel) | 2026 | 41892837 | PubTator, text mining | PubMed |
| The Future of Epigenetics: Emerging Technologies and Clinical Applications. | ACS Pharmacol Transl Sci | 2026 | 41852637 | PubTator, text mining | PubMed |
| TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells. | Life Sci Alliance | 2026 | 41844278 | PubTator, text mining | PubMed |
1 to 10 of 2,206
See all 2,206 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9002
GET https://conductscience.org/api/genes/v1/9002/patents?page=2