ConductScience.org, home

Gene · 9002

F2RL3: F2R like thrombin or trypsin receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. F2RL3: F2R like thrombin or trypsin receptor 3. Genes, record 9002. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9002

On this page

Gene

Symbol
F2RL3
HGNC
Name
F2R like thrombin or trypsin receptor 3
HGNC
NCBI Gene ID
9002
NCBI Gene
HGNC ID
HGNC:3540
HGNC
Ensembl
ENSG00000127533
NCBI Gene
Aliases
PAR4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q96RI0Proteinase-activated receptor 43853Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1441712Q96RI0Espacenet
EP 4650780 A22025-11-191238Q96RI0Espacenet
US 12441790 B22025-10-1419Q96RI0Espacenet
JP 2025147176 A2025-10-064971Q96RI0Espacenet
JP 2025529142 A2025-09-041468Q96RI0Espacenet
JP 2025529142 A2025-09-046312Q96RI0Espacenet
US 12371689 B22025-07-291468Q96RI0Espacenet
US 12371689 B22025-07-296312Q96RI0Espacenet
JP 2025517970 A2025-06-121238Q96RI0Espacenet
JP 2025028160 A2025-02-284971Q96RI0Espacenet

1 to 10 of 38

See all 38 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
BMS-986141CHEMBL3716552Proteinase activated receptor 4 antagonistANTAGONIST

Source ChEMBL

Trials1

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first posted
NCT05093790BMS-986141PHASE22023-12-05

NIH grants1,327

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleF2RL3 papersNewest fiscal year
R01HL049413Structural basis of prothrombin activation92025
R01HL101917Protease Activated Receptor and Thrombomodulin Signaling by coagulation proteases72025
P30CA016672Cancer Center Support Grant62025
P30ES009089Center for Environmental Health in Northern Manhattan62025
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation62025
R01HL136389The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis62025
UL1TR001863Yale Clinical and Translational Science Award62025
R01HL101972Characterization of Coagulation Factor-platelet Interactions: Role of FXI52025
P30AI036219Rustbelt Center for AIDS Research (Case/UHC-Pitt CFAR)42025
P30CA043703Case Comprehensive Cancer Center Support Grant42025

1 to 10 of 1,327Source NIH's project files

See all 1,327 nih grants

Papers2,206

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Impact of C-terminal amidation on platelet activation by protease-activated receptors 1 and 4 activating peptides: communication from the ISTH SSC Subcommittee on Platelets in Health and Disease.J Thromb Haemost202642810688PubTator, text miningPubMed
Papain reproduces the prothrombin-dependent PAR1/PAR4 signalling mechanism of the house dust mite allergen Der p 1.Mol Immunol202642727264PubTator, text miningPubMed
GPCRs interaction with LGR5: Implications to cancer stemness.J Cancer202642577862PubTator, text miningPubMed
hsa-miR-3529-5p through F2RL3 Regulation as an Enhancer of Sensitivity to Cisplatin.Indian J Clin Biochem202642500345PubTator, text miningPubMed
Characterizing tumor-associated endothelial cells in clear cell renal cell carcinoma via scRNA-seq and Bulk RNA-seq: construction of a prognostic risk signature.Arch Biochem Biophys202642392347PubTator, text miningPubMed
Structural mechanisms for self-activation of protease-activated receptor 4 by tethered ligand.Cell Rep202642378089PubTator, text miningPubMed
Blood DNA Methylation Patterns Across Carotid, Coronary, and Peripheral Atherosclerosis: A Comparative Analysis in 2 Prospective Cohorts.J Am Coll Cardiol202642233926PubTator, text miningPubMed
An EV-Guided Multi-Compartment Proof-of-Concept Framework for Biomarker Prioritization in Cholangiocarcinoma.Med Sci (Basel)202641892837PubTator, text miningPubMed
The Future of Epigenetics: Emerging Technologies and Clinical Applications.ACS Pharmacol Transl Sci202641852637PubTator, text miningPubMed
TBXA2R activates ERMs to drive motility, invasion, and metastatic colonization of TNBC cells.Life Sci Alliance202641844278PubTator, text miningPubMed

1 to 10 of 2,206

See all 2,206 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9002

GET https://conductscience.org/api/genes/v1/9002/patents?page=2