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Gene · 9020

MAP3K14: mitogen-activated protein kinase kinase kinase 14

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MAP3K14: mitogen-activated protein kinase kinase kinase 14. Genes, record 9020. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9020

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Gene

Symbol
MAP3K14
HGNC
Name
mitogen-activated protein kinase kinase kinase 14
HGNC
NCBI Gene ID
9020
NCBI Gene
HGNC ID
HGNC:6853
HGNC
Ensembl
ENSG00000006062
NCBI Gene
Aliases
FTDCR1B, HS, HSNIK, IMD112, NIK
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99558Mitogen-activated protein kinase kinase kinase 149478Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1918343Q99558Espacenet
JP 2025524002 A2025-07-2519Q99558Espacenet
JP 2025517970 A2025-06-1218343Q99558Espacenet
KR 1020250039465 A2025-03-2019Q99558Espacenet
JP 2024023699 A2024-02-2119Q99558Espacenet
JP 2024505890 A2024-02-0819Q99558Espacenet
JP 2023509886 A2023-03-1019Q99558Espacenet
US 11446398 B22022-09-2052541Q99558Espacenet
US 11446398 B22022-09-2052543Q99558Espacenet
KR 1020220123023 A2022-09-0519Q99558Espacenet

1 to 10 of 24

See all 24 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,408

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMAP3K14 papersNewest fiscal year
P30CA016672Cancer Center Support Grant402025
P30CA008748Cancer Center Support Grant122025
P30CA072720Cancer Center Support Grant102025
P30CA086862Cancer Center Support Grant92025
P30ES005605Environmental Health Sciences Research Center82025
P30CA030199Cancer Center Support Grant (CCSG)72025
UL1TR001863Yale Clinical and Translational Science Award72025
P01CA100730Retrovirus Models of Cancer62025
P30CA014520UW Comprehensive Cancer Center Support62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant62025

1 to 10 of 2,408Source NIH's project files

See all 2,408 nih grants

Papers3,446

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Glucose-deprived tumor microenvironment activates AMP-activated protein kinase to drive adoptively transferred T helper 9 cell senescence.Immunity202642822442PubTator, text miningPubMed
UBE2L6 drives ulcerative colitis progression by promoting BIRC2 degradation and activating non-canonical NF-κB signalling.Inflamm Res202642786362PubTator, text miningPubMed
From M1/M2 polarization to disease-associated microglial states: refining the role of NIK in diabetic retinopathy.J Transl Med202642750059PubTator, text miningPubMed
KSHV promotes leukocyte adhesion and transendothelial migration via induction of VCAM1.mBio202642708602PubTator, text miningPubMed
MAP3K14 (NIK) synonymous variants drive altered splicing to activate NF-κB in mature B-cell malignancies.Blood202642683823PubTator, text miningPubMed
ELF3 links kidney function GWAS loci to maladaptive epithelial inflammation.Sci Adv202642497247PubTator, text miningPubMed
Targeting tumor cell-intrinsic POU4F1 enhances antitumor immunity and sensitizes tumors to immunotherapy in basal-like breast cancer by modulating macrophage recruitment and polarization.Cancer Lett202642492831PubTator, text miningPubMed
A Detrimental NFKB2 Missense Variant is Associated with Hypogammaglobulinemia.J Clin Immunol202642432294PubTator, text miningPubMed
Could we discuss the molecular signature of immune dysregulation?Clin Exp Immunol202642400499PubTator, text miningPubMed
Overexpression of SLC44A4 suppresses ferroptosis and reduces lipid peroxidation via noncanonical NF-κB signaling in a NIK-dependent manner.Ann Med202642186342PubTator, text miningPubMed

1 to 10 of 3,446

See all 3,446 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9020

GET https://conductscience.org/api/genes/v1/9020/patents?page=2