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SOCS3: suppressor of cytokine signaling 3

1 protein, 84 patents, 0 drugs, 0 trials, 5,122 NIH grants and 9,802 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolSOCS3HGNC
Namesuppressor of cytokine signaling 3HGNC
NCBI Gene ID9021NCBI Gene
HGNC IDHGNC:19391HGNC
EnsemblENSG00000184557NCBI Gene
AliasesATOD4, CIS3, Cish3, SOCS-3, SSI-3, SSI3NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O14543Suppressor of cytokine signaling 32250Ensembl, GeneID, HGNCUniProt

Patents 84

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0371O14543Espacenet
EP 4641202 A22025-10-295026O14543Espacenet
WO 2025217136 A22025-10-16240O14543Espacenet
JP 2025147176 A2025-10-0616600O14543Espacenet
WO 2025163107 A12025-08-073O14543Espacenet
US 12246049 B22025-03-1128O14543Espacenet
JP 2025028160 A2025-02-2816600O14543Espacenet
KR 1020250017231 A2025-02-045026O14543Espacenet
KR 1020250010750 A2025-01-2116600O14543Espacenet
WO 2024252368 A22024-12-1227O14543Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 5122

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant222,025NIH's project files
P30CA016672Cancer Center Support Grant182,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)182,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
P30CA068485Cancer Center Support Grant122,025NIH's project files
P30DK063491Diabetes Research Center (DRC)122,025NIH's project files
R01AI046712Activation of Macrophages in Human Autoimmune Diseases102,025NIH's project files
R01AR046713Cytokine regulation of RA synoviocyte phenotype102,025NIH's project files
R01AR050401Cytokine Balance in Rheumatoid Arthritis102,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases92,025NIH's project files

Papers 9802

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42825374PubTator, text miningPubMed
42780824PubTator, text miningPubMed
42755588PubTator, text miningPubMed
42745343PubTator, text miningPubMed
42741040PubTator, text miningPubMed
42726758PubTator, text miningPubMed
42692105PubTator, text miningPubMed
42665495PubTator, text miningPubMed
42657219PubTator, text miningPubMed
42655930PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license