Gene · 90550
MCU: mitochondrial calcium uniporter
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. MCU: mitochondrial calcium uniporter. Genes, record 90550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/90550
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q8NE86 | Calcium uniporter protein, mitochondrial | 351 | 19 | Ensembl, GeneID, HGNC |
Source UniProt
Patents26
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 53658 | Q8NE86 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9228 | Q8NE86 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9464 | Q8NE86 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2583 | Q8NE86 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2583 | Q8NE86 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 9464 | Q8NE86 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 9228 | Q8NE86 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 51772 | Q8NE86 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 5733 | Q8NE86 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 154743 | Q8NE86 | Espacenet |
1 to 10 of 26
See all 26 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,334
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | MCU papers | Newest fiscal year |
|---|---|---|---|
| P01HL134608 | Exosomes as mediators of cardiac injury and repair | 12 | 2025 |
| R01HL122124 | Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ Dynamics | 9 | 2025 |
| I01BX000163 | Leveraging mitochondrial function to combat radiation therapy-induced microvascular disease | 7 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| R01DK135179 | Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLD | 6 | 2025 |
| R35GM145294 | Magnesium flux compendium: Discover ligands, channels, and metabolic signals | 6 | 2025 |
| ZIAHL002066 | Mechanisms of cardiac ischemia-reperfusion injury and cardioprotection | 6 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 5 | 2025 |
| P30ES005605 | Environmental Health Sciences Research Center | 5 | 2025 |
| R01CA250173 | Endoplasmic Reticulum-to-Mitochondria Calcium Transfer in Pancreatic Cancer Development, Metastasis, and Treatment | 5 | 2025 |
1 to 10 of 1,334Source NIH's project files
See all 1,334 nih grantsPapers2,226
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated transcriptomic and deep learning analyses define acRG signature for prognosis and therapeutic options in osteosarcoma. | Biochim Biophys Acta Mol Basis Dis | 2026 | 42826870 | PubTator, text mining | PubMed |
| METTL3-mediated m⁶A methylation of E2F2 targets MCU to promote the malignant phenotype of gastric cancer cells. | Cancer Gene Ther | 2026 | 42823456 | PubTator, text mining | PubMed |
| Mitochondrial Ca2+ homeostasis in ovarian function and oocyte competence: from molecular transporters to early embryonic development. | Front Cell Dev Biol | 2026 | 42798439 | PubTator, text mining | PubMed |
| Context-Dependent modulation of astrocytic Ca2+ signals by mitochondria: a computational study. | J Comput Neurosci | 2026 | 42789229 | PubTator, text mining | PubMed |
| Mitochondrial calcium influx-driven bioenergetics selectively enable drug addiction. | Nat Neurosci | 2026 | 42686884 | PubTator, text mining | PubMed |
| Hypertensive mt. tRNAIle4263A>G mutation orchestrates vascular senescence and apoptosis by activation of mitochondria-ER interplay. | Redox Biol | 2026 | 42679745 | PubTator, text mining | PubMed |
| Repression of ferroptotic cell death mediated antitumor immunity by mitochondrial calcium signaling. | Proc Natl Acad Sci U S A | 2026 | 42616778 | PubTator, text mining | PubMed |
| Mitochondrial calcium uniporter as a biomarker in lung adenocarcinoma: regulation of the immune microenvironment, apoptosis, cell cycle and mitophagy. | Am J Cancer Res | 2026 | 42597465 | PubTator, text mining | PubMed |
| Mitochondrial dynamics and ion channel regulation of cancer stem cells (CSCs) in metabolic flexibility and therapeutic targeting. | Stem Cells | 2026 | 42593212 | PubTator, text mining | PubMed |
| Piezo1-mitochondrial calcium coupling in mechanotransduction, mitochondrial stress, and cell fate. | Cell Calcium | 2026 | 42556178 | PubTator, text mining | PubMed |
1 to 10 of 2,226
See all 2,226 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/90550
GET https://conductscience.org/api/genes/v1/90550/patents?page=2