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Gene · 90550

MCU: mitochondrial calcium uniporter

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. MCU: mitochondrial calcium uniporter. Genes, record 90550. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/90550

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Gene

Symbol
MCU
HGNC
Name
mitochondrial calcium uniporter
HGNC
NCBI Gene ID
90550
NCBI Gene
HGNC ID
HGNC:23526
HGNC
Ensembl
ENSG00000156026
NCBI Gene
Aliases
C10orf42, CCDC109A, FLJ46135, HsMCU
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q8NE86Calcium uniporter protein, mitochondrial35119Ensembl, GeneID, HGNC

Source UniProt

Patents26

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1453658Q8NE86Espacenet
EP 4650780 A22025-11-199228Q8NE86Espacenet
EP 4641201 A22025-10-299464Q8NE86Espacenet
JP 2025529142 A2025-09-042583Q8NE86Espacenet
US 12371689 B22025-07-292583Q8NE86Espacenet
JP 2025517969 A2025-06-129464Q8NE86Espacenet
JP 2025517970 A2025-06-129228Q8NE86Espacenet
US 11446398 B22022-09-2051772Q8NE86Espacenet
US 11400116 B22022-08-025733Q8NE86Espacenet
JP 2022524081 A2022-04-27154743Q8NE86Espacenet

1 to 10 of 26

See all 26 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,334

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleMCU papersNewest fiscal year
P01HL134608Exosomes as mediators of cardiac injury and repair122025
R01HL122124Mitochondria-SR Tethering: Its Role in Cardiac Bioenergetics and Ca2+ Dynamics92025
I01BX000163Leveraging mitochondrial function to combat radiation therapy-induced microvascular disease72025
P30CA008748Cancer Center Support Grant62025
R01DK135179Mechanisms and therapeutic potential of blocking the mitochondrial Mg2+ channel Mrs2 in obesity and NAFLD62025
R35GM145294Magnesium flux compendium: Discover ligands, channels, and metabolic signals62025
ZIAHL002066Mechanisms of cardiac ischemia-reperfusion injury and cardioprotection62025
P30CA086862Cancer Center Support Grant52025
P30ES005605Environmental Health Sciences Research Center52025
R01CA250173Endoplasmic Reticulum-to-Mitochondria Calcium Transfer in Pancreatic Cancer Development, Metastasis, and Treatment52025

1 to 10 of 1,334Source NIH's project files

See all 1,334 nih grants

Papers2,226

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated transcriptomic and deep learning analyses define acRG signature for prognosis and therapeutic options in osteosarcoma.Biochim Biophys Acta Mol Basis Dis202642826870PubTator, text miningPubMed
METTL3-mediated m⁶A methylation of E2F2 targets MCU to promote the malignant phenotype of gastric cancer cells.Cancer Gene Ther202642823456PubTator, text miningPubMed
Mitochondrial Ca2+ homeostasis in ovarian function and oocyte competence: from molecular transporters to early embryonic development.Front Cell Dev Biol202642798439PubTator, text miningPubMed
Context-Dependent modulation of astrocytic Ca2+ signals by mitochondria: a computational study.J Comput Neurosci202642789229PubTator, text miningPubMed
Mitochondrial calcium influx-driven bioenergetics selectively enable drug addiction.Nat Neurosci202642686884PubTator, text miningPubMed
Hypertensive mt. tRNAIle4263A>G mutation orchestrates vascular senescence and apoptosis by activation of mitochondria-ER interplay.Redox Biol202642679745PubTator, text miningPubMed
Repression of ferroptotic cell death mediated antitumor immunity by mitochondrial calcium signaling.Proc Natl Acad Sci U S A202642616778PubTator, text miningPubMed
Mitochondrial calcium uniporter as a biomarker in lung adenocarcinoma: regulation of the immune microenvironment, apoptosis, cell cycle and mitophagy.Am J Cancer Res202642597465PubTator, text miningPubMed
Mitochondrial dynamics and ion channel regulation of cancer stem cells (CSCs) in metabolic flexibility and therapeutic targeting.Stem Cells202642593212PubTator, text miningPubMed
Piezo1-mitochondrial calcium coupling in mechanotransduction, mitochondrial stress, and cell fate.Cell Calcium202642556178PubTator, text miningPubMed

1 to 10 of 2,226

See all 2,226 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/90550

GET https://conductscience.org/api/genes/v1/90550/patents?page=2