Gene · 9075
CLDN2: claudin 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. CLDN2: claudin 2. Genes, record 9075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9075
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P57739 | Claudin-2 | 230 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents378
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025529142 A | 2025-09-04 | 982 | P57739 | Espacenet |
| WO 2025177214 A1 | 2025-08-28 | 21 | P57739 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 982 | P57739 | Espacenet |
| JP 2024522861 A | 2024-06-21 | 49 | P57739 | Espacenet |
| JP 2023547662 A | 2023-11-13 | 5 | P57739 | Espacenet |
| US 11692031 B2 | 2023-07-04 | 6 | P57739 | Espacenet |
| KR 1020230098334 A | 2023-07-03 | 5 | P57739 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 17551 | P57739 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 17552 | P57739 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 17553 | P57739 | Espacenet |
1 to 10 of 378
See all 378 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,300
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | CLDN2 papers | Newest fiscal year |
|---|---|---|---|
| R01DK068271 | Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease. | 35 | 2025 |
| R01DK061931 | Mechanisms and pathophysiologic impact of claudin-2 modulation | 34 | 2025 |
| P30DK058404 | Molecular and Cellular Basis for Digestive Diseases | 17 | 2025 |
| P30DK034854 | Integrated Epithelial and Muscosal Biology | 14 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 13 | 2025 |
| R01DK091281 | A Novel Role for PTPN2 in Intestinal Epithelial Barrier Regulation | 11 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 10 | 2025 |
| P30DK042086 | Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID) | 10 | 2025 |
| U01DK108306 | UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes | 9 | 2025 |
| U01DK108334 | INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies | 9 | 2025 |
1 to 10 of 1,300Source NIH's project files
See all 1,300 nih grantsPapers2,543
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Novel associations of Claudin gene variants with kidney stone disease. | Clin Kidney J | 2026 | 42824688 | PubTator, text mining | PubMed |
| Establishment of an In Vitro DSS-Induced Epithelial Injury Model to Investigate Dose-Dependent Effects of IL-6 and Butyrate on Barrier Function. | Int J Mol Sci | 2026 | 42794457 | PubTator, text mining | PubMed |
| Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization. | Int J Mol Sci | 2026 | 42737845 | PubTator, text mining | PubMed |
| Graded levels of wheat oligopeptides relieve feed change-induced intestinal damage via modulation of the Wnt/β-catenin signaling pathway in broilers. | Anim Nutr | 2026 | 42729218 | PubTator, text mining | PubMed |
| Astragaloside IV ameliorates DSS-induced intestinal epithelial barrier dysfunction associated with modulation of tight junction proteins and MLCK/p-MLC and MyD88/TRAF6 signaling pathways. | Front Pharmacol | 2026 | 42698578 | PubTator, text mining | PubMed |
| Development of a tissue-based risk prediction model combining histology and barrier biomarkers for clinical relapse in ulcerative colitis with endoscopic healing. | Ther Adv Gastroenterol | 2026 | 42666420 | PubTator, text mining | PubMed |
| Circulating PDIA4, MMP-2, MMP-9, and Claudin-2 in Vitamin D-Deficient Patients with Brain Tumors: An Exploratory Clinical Pilot Study. | J Clin Med | 2026 | 42652596 | PubTator, text mining | PubMed |
| Breaking the Barrier: Pro-inflammatory Stool from Infants with CHD Triggers Barrier Dysfunction within Intestinal Organoids. | Res Sq | 2026 | 42619927 | PubTator, text mining | PubMed |
| NEAT1-Mediated Intestinal Barrier Dysfunction Through miR-29b-3p Binding in Lipopolysaccharide-Damaged Caco-2 Cells. | J Vis Exp | 2026 | 42611728 | PubTator, text mining | PubMed |
| The effect of increasing dietary Vitamin E and D doses on the performance of broilers and CLDN2 gene expression during experimental heat stress. | Vet Anim Sci | 2026 | 42568895 | PubTator, text mining | PubMed |
1 to 10 of 2,543
See all 2,543 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9075
GET https://conductscience.org/api/genes/v1/9075/patents?page=2