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Gene · 9075

CLDN2: claudin 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CLDN2: claudin 2. Genes, record 9075. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9075

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Gene

Symbol
CLDN2
HGNC
Name
claudin 2
HGNC
NCBI Gene ID
9075
NCBI Gene
HGNC ID
HGNC:2041
HGNC
Ensembl
ENSG00000165376
NCBI Gene
Aliases
OAZON, claudin-2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P57739Claudin-22301Ensembl, GeneID, HGNC

Source UniProt

Patents378

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-04982P57739Espacenet
WO 2025177214 A12025-08-2821P57739Espacenet
US 12371689 B22025-07-29982P57739Espacenet
JP 2024522861 A2024-06-2149P57739Espacenet
JP 2023547662 A2023-11-135P57739Espacenet
US 11692031 B22023-07-046P57739Espacenet
KR 1020230098334 A2023-07-035P57739Espacenet
US 11446398 B22022-09-2017551P57739Espacenet
US 11446398 B22022-09-2017552P57739Espacenet
US 11446398 B22022-09-2017553P57739Espacenet

1 to 10 of 378

See all 378 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,300

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCLDN2 papersNewest fiscal year
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.352025
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation342025
P30DK058404Molecular and Cellular Basis for Digestive Diseases172025
P30DK034854Integrated Epithelial and Muscosal Biology142025
P30CA068485Cancer Center Support Grant132025
R01DK091281A Novel Role for PTPN2 in Intestinal Epithelial Barrier Regulation112025
P30CA014599Cancer Center Support Grant102025
P30DK042086Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)102025
U01DK108306UPMC Clinical Center for the Study of Chronic Pancreatitis and Diabetes92025
U01DK108334INSPPIRE: Using the natural history of pediatric chronic pancreatitis to identify disease predictors and design therapies92025

1 to 10 of 1,300Source NIH's project files

See all 1,300 nih grants

Papers2,543

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Novel associations of Claudin gene variants with kidney stone disease.Clin Kidney J202642824688PubTator, text miningPubMed
Establishment of an In Vitro DSS-Induced Epithelial Injury Model to Investigate Dose-Dependent Effects of IL-6 and Butyrate on Barrier Function.Int J Mol Sci202642794457PubTator, text miningPubMed
Conserved Epithelial Remodeling Programs Underlie Pediatric Juvenile Colorectal Polyps Associated with Allergic Sensitization.Int J Mol Sci202642737845PubTator, text miningPubMed
Graded levels of wheat oligopeptides relieve feed change-induced intestinal damage via modulation of the Wnt/β-catenin signaling pathway in broilers.Anim Nutr202642729218PubTator, text miningPubMed
Astragaloside IV ameliorates DSS-induced intestinal epithelial barrier dysfunction associated with modulation of tight junction proteins and MLCK/p-MLC and MyD88/TRAF6 signaling pathways.Front Pharmacol202642698578PubTator, text miningPubMed
Development of a tissue-based risk prediction model combining histology and barrier biomarkers for clinical relapse in ulcerative colitis with endoscopic healing.Ther Adv Gastroenterol202642666420PubTator, text miningPubMed
Circulating PDIA4, MMP-2, MMP-9, and Claudin-2 in Vitamin D-Deficient Patients with Brain Tumors: An Exploratory Clinical Pilot Study.J Clin Med202642652596PubTator, text miningPubMed
Breaking the Barrier: Pro-inflammatory Stool from Infants with CHD Triggers Barrier Dysfunction within Intestinal Organoids.Res Sq202642619927PubTator, text miningPubMed
NEAT1-Mediated Intestinal Barrier Dysfunction Through miR-29b-3p Binding in Lipopolysaccharide-Damaged Caco-2 Cells.J Vis Exp202642611728PubTator, text miningPubMed
The effect of increasing dietary Vitamin E and D doses on the performance of broilers and CLDN2 gene expression during experimental heat stress.Vet Anim Sci202642568895PubTator, text miningPubMed

1 to 10 of 2,543

See all 2,543 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9075

GET https://conductscience.org/api/genes/v1/9075/patents?page=2