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CLDN1: claudin 1

1 protein, 261 patents, 0 drugs, 0 trials, 3,217 NIH grants and 8,712 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolCLDN1HGNC
Nameclaudin 1HGNC
NCBI Gene ID9076NCBI Gene
HGNC IDHGNC:2032HGNC
EnsemblENSG00000163347NCBI Gene
AliasesCLD1, ILVASC, SEMP1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O95832Claudin-12110Ensembl, GeneID, HGNCUniProt

Patents 261

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026082974 A2026-05-19115O95832Espacenet
JP 2026004568 A2026-01-1441643O95832Espacenet
WO 2025244006 A2025-11-274O95832Espacenet
EP 4650780 A22025-11-193624O95832Espacenet
JP 2025529142 A2025-09-04972O95832Espacenet
WO 2025177214 A12025-08-2820O95832Espacenet
US 12371689 B22025-07-29972O95832Espacenet
JP 2025517970 A2025-06-123624O95832Espacenet
EP 4527406 A12025-03-2685O95832Espacenet
JP 2025032204 A2025-03-1126453O95832Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3217

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant192,025NIH's project files
R01DK061931Mechanisms and pathophysiologic impact of claudin-2 modulation182,025NIH's project files
R01DK068271Therapeutic targeting of protein interactions to reverse MLCK1-mediated intestinal barrier loss and ameliorate disease.182,025NIH's project files
P30CA068485Cancer Center Support Grant162,025NIH's project files
R01AI107301Genetic Viral and Host Adaptations to Breach Species Barriers of HCV152,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases132,025NIH's project files
R01DK104713Metabolic Regulation of Inflammation by Microbial SCFA132,025NIH's project files
P30CA008748Cancer Center Support Grant122,025NIH's project files
R01DK095491Indole dysbiosis and mucosal inflammation112,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease102,025NIH's project files

Papers 8712

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42811626PubTator, text miningPubMed
42800590PubTator, text miningPubMed
42798839PubTator, text miningPubMed
42797076PubTator, text miningPubMed
42795619PubTator, text miningPubMed
42790022PubTator, text miningPubMed
42770193PubTator, text miningPubMed
42755235PubTator, text miningPubMed
42753829PubTator, text miningPubMed
42738948PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license