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IL33: interleukin 33

1 protein, 263 patents, 3 drugs, 20 trials, 6,468 NIH grants and 16,265 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolIL33HGNC
Nameinterleukin 33HGNC
NCBI Gene ID90865NCBI Gene
HGNC IDHGNC:16028HGNC
EnsemblENSG00000137033NCBI Gene
AliasesC9orf26, DKFZp586H0523, DVS27, IL1F11, NF-HEV, NFEHEVNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O95760Interleukin-332705Ensembl, GeneID, HGNCUniProt

Patents 263

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4795154 A12026-08-26116O95760Espacenet
WO 2026167214 A12026-08-1386O95760Espacenet
EP 4757832 A12026-06-17401O95760Espacenet
JP 2026517179 A2026-05-289O95760Espacenet
JP 2026082951 A2026-05-198O95760Espacenet
US 12624114 B22026-05-12348O95760Espacenet
US 12612462 B22026-04-28348O95760Espacenet
EP 4724500 A22026-04-15416O95760Espacenet
JP 2026512261 A2026-04-1573O95760Espacenet
EP 4713461 A22026-03-259O95760Espacenet

Drugs 3

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ETOKIMABCHEMBL4297580Interleukin-33 binding agentBINDING AGENTChEMBL
ITEPEKIMABCHEMBL4594594Interleukin-33 inhibitorINHIBITORChEMBL
TORUDOKIMABCHEMBL4650487Interleukin-33 inhibitorINHIBITORChEMBL

Trials 20

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07484230ITEPEKIMABPHASE3ClinicalTrials.gov
NCT07424144ITEPEKIMABPHASE3ClinicalTrials.gov
NCT06834360ITEPEKIMABPHASE3ClinicalTrials.gov
NCT06834347ITEPEKIMABPHASE3ClinicalTrials.gov
NCT06691113ITEPEKIMABPHASE2ClinicalTrials.gov
NCT06280391ITEPEKIMABPHASE2ClinicalTrials.gov
NCT06208306ITEPEKIMABPHASE3ClinicalTrials.gov
NCT05326412ITEPEKIMABPHASE2ClinicalTrials.gov
NCT04751487ITEPEKIMABPHASE3ClinicalTrials.gov
NCT04701983ITEPEKIMABPHASE3ClinicalTrials.gov

NIH grants 6468

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease362,025NIH's project files
U19AI070235Epithelial Genes in Allergic Inflammation352,025NIH's project files
U19AI095227Viral and Host Determinants of Infant and Childhood Allergy and Asthma352,025NIH's project files
P30CA008748Cancer Center Support Grant312,025NIH's project files
U19AI070535Airway Inflammation and Airway Remodeling in Severe Asthma292,025NIH's project files
U01AI095608Regulation of mucosal immunity by neuronal pathways252,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases212,025NIH's project files
U19AI095219Pathophysiologic and Therapeutic Mechanisms of Aspirin Exacerbated Respiratory Disease202,025NIH's project files
U19AI077439Immune-driven Airway Epithelial Dysfunction in Muco-obstructive Asthma192,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award192,025NIH's project files

Papers 16265

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42823320PubTator, text miningPubMed
42818167PubTator, text miningPubMed
42806728PubTator, text miningPubMed
42802784PubTator, text miningPubMed
42801082PubTator, text miningPubMed
42795262PubTator, text miningPubMed
42794756PubTator, text miningPubMed
42794682PubTator, text miningPubMed
42786844PubTator, text miningPubMed
42786842PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license