ConductScience.org, home

Gene · 9097

USP14: ubiquitin specific peptidase 14

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. USP14: ubiquitin specific peptidase 14. Genes, record 9097. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9097

On this page

Gene

Symbol
USP14
HGNC
Name
ubiquitin specific peptidase 14
HGNC
NCBI Gene ID
9097
NCBI Gene
HGNC ID
HGNC:12612
HGNC
Ensembl
ENSG00000101557
NCBI Gene
Aliases
TGT, Ubp6
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54578Ubiquitin carboxyl-terminal hydrolase 1449423Ensembl, GeneID, HGNC

Source UniProt

Patents37

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468972P54578Espacenet
EP 4650780 A22025-11-191921P54578Espacenet
JP 2025147176 A2025-10-0613951P54578Espacenet
JP 2025529142 A2025-09-048013P54578Espacenet
US 12371689 B22025-07-298013P54578Espacenet
JP 2025517970 A2025-06-121921P54578Espacenet
JP 2025028160 A2025-02-2813951P54578Espacenet
KR 1020250010750 A2025-01-2113951P54578Espacenet
EP 4426882 A12024-09-11289P54578Espacenet
JP 2024109657 A2024-08-1413958P54578Espacenet

1 to 10 of 37

See all 37 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants901

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSP14 papersNewest fiscal year
ZIABC011490Maintaining cell health by targeted protein degradation82025
P30CA022453CANCER CENTER SUPPORT GRANT62025
P01CA155258Integrative Oncogenomics of Multiple Myeloma52025
R01GM065334Solution structure and dynamics of polyubiquitin chains52025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P20GM103476Mississippi INBRE32025
P30CA006973Regional Oncology Research Center32025
P30CA023168Cancer Center Support Grant32025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center32025

1 to 10 of 901Source NIH's project files

See all 901 nih grants

Papers1,667

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting USP14 sensitizes glioma to radiotherapy through exacerbated reactive oxygen species accumulation.Med Gas Res202742734450PubTator, text miningPubMed
CD81 drives immune evasion in radioresistant glioblastoma by blocking selective autophagic degradation of CD274/PD-L1.Autophagy202642733113PubTator, text miningPubMed
Therapeutics candidates and repurposing strategies to target parkinson's disease pathology: current evidence and future directions.Metab Brain Dis202642714656PubTator, text miningPubMed
USP14 competitively binds to FBXW7 to stabilize MTDH and promotes metastasis and drug resistance of head and neck squamous cell carcinoma.Proc Natl Acad Sci U S A202642616774PubTator, text miningPubMed
Zebrafish USP14 suppresses RIG-I-mediated innate antiviral immunity via targeted deubiquitination to facilitate SVCV replication.Fish Shellfish Immunol202642607976PubTator, text miningPubMed
The Dual Roles of Microglia- and Astrocyte-Derived Exosomes in Cerebral Ischemia-Reperfusion Injury: from Intercellular Communication to Therapeutic Prospects.Mol Neurobiol202642547642PubTator, text miningPubMed
VLX1570 suppresses neuroblastoma growth through inhibition of PCNA-associated proliferative signaling and potentiates cisplatin antitumor activity.Front Pharmacol202642529093PubTator, text miningPubMed
USP14 promotes head and neck squamous cell carcinoma progression via deubiquitinating and stabilizing CFL2.Future Sci OA202642454444PubTator, text miningPubMed
Structure-guided design of potent and selective covalent inhibitors of SARS-CoV-1 and SARS-CoV-2 papain-like proteases with antiviral activity.Eur J Med Chem202642430953PubTator, text miningPubMed
The mechanism of deubiquitinase USP14 modifying HSP90AA1 to activate NRF2 signaling in lung cancer cell resistance to ferroptosis.Mol Biol Rep202642429998PubTator, text miningPubMed

1 to 10 of 1,667

See all 1,667 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9097

GET https://conductscience.org/api/genes/v1/9097/patents?page=2