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Gene · 91

ACVR1B: activin A receptor type 1B

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACVR1B: activin A receptor type 1B. Genes, record 91. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/91

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Gene

Symbol
ACVR1B
HGNC
Name
activin A receptor type 1B
HGNC
NCBI Gene ID
91
NCBI Gene
HGNC ID
HGNC:172
HGNC
Ensembl
ENSG00000135503
NCBI Gene
Aliases
ACTRIB, ACVRLK4, ALK4, ActRIB, SKR2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P36896Activin receptor type-1B5052Ensembl, GeneID, HGNC

Source UniProt

Patents89

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026062645 A2026-04-10251P36896Espacenet
JP 2026026172 A2026-02-16100P36896Espacenet
JP 2026004568 A2026-01-1436234P36896Espacenet
EP 4650780 A22025-11-191661P36896Espacenet
EP 4641201 A22025-10-291267P36896Espacenet
US 12421295 B22025-09-2326P36896Espacenet
JP 2025529142 A2025-09-04256P36896Espacenet
US 12371689 B22025-07-29256P36896Espacenet
US 12343378 B22025-07-01100P36896Espacenet
JP 2025517969 A2025-06-121267P36896Espacenet

1 to 10 of 89

See all 89 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,351

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACVR1B papersNewest fiscal year
P30CA016672Cancer Center Support Grant92025
P30CA008748Cancer Center Support Grant82025
P30CA068485Cancer Center Support Grant62025
P01AI127335Human Cytomegalovirus dysregulation of host hematopoietic progenitor cell signaling pathways to modulate latency and reactivation52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases52025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA054174Mays Cancer Center at UT Health SA42025
R01HD032067Transforming growth factor β family signaling pathways in ovarian and uterine biology42025
T32CA009592Microenvironmental Influences in Cancer42025
P30CA006973Regional Oncology Research Center32025

1 to 10 of 1,351Source NIH's project files

See all 1,351 nih grants

Papers1,784

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Targeting TGFBR1 with the Investigational Inhibitor TP-6379 Improves Hematopoiesis in Low-Risk MDS Ex Vivo.Cells202642782774PubTator, text miningPubMed
Productive Mayaro Virus Infection Requires Host Fatty Acid Synthase for nsP1 S-palmitoylation.bioRxiv202642539173PubTator, text miningPubMed
Upregulation of HIF1A /miR-210 and downregulation of miR-383 in EOPE, IUGR, and EOPE/IUGR: Integrative bioinformatics insights into miR-383 targets.Placenta202642424821PubTator, text miningPubMed
Growth differentiation factor 11 (GDF11) signaling in neural stem cell regulation: molecular and cellular insights.Rev Neurosci202642299745PubTator, text miningPubMed
An integrative mutational and network analysis of pancreatic cancer reveals key genes, and signalling pathways.Funct Integr Genomics202642277390PubTator, text miningPubMed
Activin A in the central nervous system: Mechanistic and therapeutic insights unveiled by emerging technologies.Neural Regen Res202642199099PubTator, text miningPubMed
RUNX1-mediated repression of miR-24 promotes hepatic stellate cell activation and liver fibrosis by targeting the ALK4/Smad3 signaling pathway.Front Genet202642137245PubTator, text miningPubMed
Growth differentiation factor-11 stimulates human extravillous trophoblast cell invasion by upregulating Slug-mediated N-cadherin expression.Placenta202642097099PubTator, text miningPubMed
Genome-wide association study of myopia progression in Chinese adolescents and application of polygenic risk score prediction.Front Chem202642094695PubTator, text miningPubMed
Crosstalk between KRAS and miRNAs in pancreatic cancer: Opportunities for its diagnosis, prognosis and therapeutic intervention (Review).Int J Oncol202641860028PubTator, text miningPubMed

1 to 10 of 1,784

See all 1,784 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/91

GET https://conductscience.org/api/genes/v1/91/patents?page=2