Gene · 9100
USP10: ubiquitin specific peptidase 10
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. USP10: ubiquitin specific peptidase 10. Genes, record 9100. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9100
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q14694 | Ubiquitin carboxyl-terminal hydrolase 10 | 798 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents25
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 68965 | Q14694 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 312 | Q14694 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 312 | Q14694 | Espacenet |
| US 11884978 B2 | 2024-01-30 | 793 | Q14694 | Espacenet |
| JP 2023551068 A | 2023-12-06 | 28 | Q14694 | Espacenet |
| JP 2023549761 A | 2023-11-29 | 28 | Q14694 | Espacenet |
| JP 2023549167 A | 2023-11-22 | 28 | Q14694 | Espacenet |
| JP 2023548973 A | 2023-11-21 | 28 | Q14694 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 94707 | Q14694 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 197678 | Q14694 | Espacenet |
1 to 10 of 25
See all 25 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants860
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | USP10 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 8 | 2025 |
| P30CA138292 | Winship Cancer Institute Cancer Center Support Grant | 4 | 2025 |
| R01EY024942 | THE UBIQUITIN PATHWAY IN CORNEAL SCARRING | 4 | 2025 |
| P30CA016056 | Roswell Park Cancer Center Support Grant | 3 | 2025 |
| P30CA022453 | CANCER CENTER SUPPORT GRANT | 3 | 2025 |
| P30CA046934 | University of Colorado Cancer Center Support Grant | 3 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30CA225520 | Stephenson Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P01CA066996 | Development of Novel Therapeutic Strategies in Human Leukemias | 2 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 2 | 2025 |
1 to 10 of 860Source NIH's project files
See all 860 nih grantsPapers1,422
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Isoform Remodeling and Promoter Switching Identify Altered Transcriptional Regulation in Alzheimer's Disease Frontal Cortex. | Res Sq | 2026 | 42818937 | PubTator, text mining | PubMed |
| USP10 stabilizes FOXM1 through KAT5-mediated acetylation to suppress cell senescence and promote melanoma malignant progression. | Int J Biol Sci | 2026 | 42807929 | PubTator, text mining | PubMed |
| Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation. | Mol Biol Rep | 2026 | 42789125 | PubTator, text mining | PubMed |
| Regulatory roles of five key USP family deubiquitinases in cancer: from mechanisms to targeted therapy advances. | Front Pharmacol | 2026 | 42787673 | PubTator, text mining | PubMed |
| USP10 is associated with TUBA1B protein stability, PI3K/AKT phosphorylation changes, and progression of triple-negative breast cancer. | Pathol Res Pract | 2026 | 42727187 | PubTator, text mining | PubMed |
| Deubiquitination of NICD1 by USP10 Restrains Esophageal Cancer: A Link Between NOTCH1 Stabilization, Oxidative Stress, and Ferroptosis. | Neoplasia | 2026 | 42710266 | PubTator, text mining | PubMed |
| USP10-dependent stabilization of UGT8 promotes oxaliplatin resistance by sustaining NRF2-associated antioxidant signaling and suppressing ferroptosis in gastric cancer. | Free Radic Biol Med | 2026 | 42648560 | PubTator, text mining | PubMed |
| G3BP1 depletion, observed in Parkinson's Disease, drives Golgi-lysosome-autophagy defects. | Cell Death Differ | 2026 | 42642486 | PubTator, text mining | PubMed |
| IL-6 Promotes Pathological Angiogenesis in Oral Submucous Fibrosis by Suppressing USP10-VEGFR1 Interaction. | J Cell Mol Med | 2026 | 42619043 | PubTator, text mining | PubMed |
| Targeting Ubiquitinated Protein Aggregates in Neurodegenerative Diseases: current Status and Future Directions. | Mol Cell Biol | 2026 | 42549923 | PubTator, text mining | PubMed |
1 to 10 of 1,422
See all 1,422 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/9100
GET https://conductscience.org/api/genes/v1/9100/patents?page=2