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Gene · 9100

USP10: ubiquitin specific peptidase 10

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. USP10: ubiquitin specific peptidase 10. Genes, record 9100. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9100

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Gene

Symbol
USP10
HGNC
Name
ubiquitin specific peptidase 10
HGNC
NCBI Gene ID
9100
NCBI Gene
HGNC ID
HGNC:12608
HGNC
Ensembl
ENSG00000103194
NCBI Gene
Aliases
KIAA0190, UBPO
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14694Ubiquitin carboxyl-terminal hydrolase 107982Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1468965Q14694Espacenet
EP 4641201 A22025-10-29312Q14694Espacenet
JP 2025517969 A2025-06-12312Q14694Espacenet
US 11884978 B22024-01-30793Q14694Espacenet
JP 2023551068 A2023-12-0628Q14694Espacenet
JP 2023549761 A2023-11-2928Q14694Espacenet
JP 2023549167 A2023-11-2228Q14694Espacenet
JP 2023548973 A2023-11-2128Q14694Espacenet
US 11446398 B22022-09-2094707Q14694Espacenet
JP 2022524081 A2022-04-27197678Q14694Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants860

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleUSP10 papersNewest fiscal year
P30CA016672Cancer Center Support Grant82025
P30CA138292Winship Cancer Institute Cancer Center Support Grant42025
R01EY024942THE UBIQUITIN PATHWAY IN CORNEAL SCARRING42025
P30CA016056Roswell Park Cancer Center Support Grant32025
P30CA022453CANCER CENTER SUPPORT GRANT32025
P30CA046934University of Colorado Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P30CA225520Stephenson Cancer Center - Cancer Center Support Grant32025
P01CA066996Development of Novel Therapeutic Strategies in Human Leukemias22025
P30CA006973Regional Oncology Research Center22025

1 to 10 of 860Source NIH's project files

See all 860 nih grants

Papers1,422

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Isoform Remodeling and Promoter Switching Identify Altered Transcriptional Regulation in Alzheimer's Disease Frontal Cortex.Res Sq202642818937PubTator, text miningPubMed
USP10 stabilizes FOXM1 through KAT5-mediated acetylation to suppress cell senescence and promote melanoma malignant progression.Int J Biol Sci202642807929PubTator, text miningPubMed
Stress granules and RNA-binding proteins in cellular senescence: a modular perspective on stress adaptation and inflammation.Mol Biol Rep202642789125PubTator, text miningPubMed
Regulatory roles of five key USP family deubiquitinases in cancer: from mechanisms to targeted therapy advances.Front Pharmacol202642787673PubTator, text miningPubMed
USP10 is associated with TUBA1B protein stability, PI3K/AKT phosphorylation changes, and progression of triple-negative breast cancer.Pathol Res Pract202642727187PubTator, text miningPubMed
Deubiquitination of NICD1 by USP10 Restrains Esophageal Cancer: A Link Between NOTCH1 Stabilization, Oxidative Stress, and Ferroptosis.Neoplasia202642710266PubTator, text miningPubMed
USP10-dependent stabilization of UGT8 promotes oxaliplatin resistance by sustaining NRF2-associated antioxidant signaling and suppressing ferroptosis in gastric cancer.Free Radic Biol Med202642648560PubTator, text miningPubMed
G3BP1 depletion, observed in Parkinson's Disease, drives Golgi-lysosome-autophagy defects.Cell Death Differ202642642486PubTator, text miningPubMed
IL-6 Promotes Pathological Angiogenesis in Oral Submucous Fibrosis by Suppressing USP10-VEGFR1 Interaction.J Cell Mol Med202642619043PubTator, text miningPubMed
Targeting Ubiquitinated Protein Aggregates in Neurodegenerative Diseases: current Status and Future Directions.Mol Cell Biol202642549923PubTator, text miningPubMed

1 to 10 of 1,422

See all 1,422 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9100

GET https://conductscience.org/api/genes/v1/9100/patents?page=2