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Gene · 9126

SMC3: structural maintenance of chromosomes 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SMC3: structural maintenance of chromosomes 3. Genes, record 9126. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9126

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Gene

Symbol
SMC3
HGNC
Name
structural maintenance of chromosomes 3
HGNC
NCBI Gene ID
9126
NCBI Gene
HGNC ID
HGNC:2468
HGNC
Ensembl
ENSG00000108055
NCBI Gene
Aliases
BAM, BMH, CDLS3, CSPG6, HCAP, SMC3L1, bamacan
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q9UQE7Structural maintenance of chromosomes protein 31,21712Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1465690Q9UQE7Espacenet
EP 4650780 A22025-11-197929Q9UQE7Espacenet
EP 4641201 A22025-10-298019Q9UQE7Espacenet
JP 2025517969 A2025-06-128019Q9UQE7Espacenet
JP 2025517970 A2025-06-127929Q9UQE7Espacenet
US 11446398 B22022-09-2084694Q9UQE7Espacenet
US 11357853 B22022-06-1430Q9UQE7Espacenet
JP 2022524081 A2022-04-27187665Q9UQE7Espacenet
US 11078247 B22021-08-0310682Q9UQE7Espacenet
WO 2020043864 A12020-03-052404Q9UQE7Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,239

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSMC3 papersNewest fiscal year
P30CA008748Cancer Center Support Grant182025
P30CA016672Cancer Center Support Grant152025
P30CA010815Consolidated Basic Cancer Research Program132025
P30CA016058Cancer Center Support Grant132025
P30CA021765Cancer Center Support Grant (CCSG)112025
R01HG003143Structural Annotation of the Human Genome112025
R01CA117830Epigenomic Control of KSHV Latency102025
U10CA180821Alliance for Clinical Trials in Oncology Operations Center - GY11 Funded Extension102025
U10CA180882Alliance Statistics and Data Management Center102025
U24CA196171The Alliance NCTN Biorepository and Biospecimen Resource102025

1 to 10 of 2,239Source NIH's project files

See all 2,239 nih grants

Papers3,065

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Discovery of cyanocarbonimidodithioates as novel non-hydroxamate zinc-binding groups for selective HDAC8 inhibition: Design, synthesis, biological evaluation, anticancer activity, and in silico studies.
Bioorg Chem202642767177PubTator, text miningPubMed
Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis.Anim Reprod Sci202642748838PubTator, text miningPubMed
Design, synthesis, and screening of novel thienopyrimidine derivatives as PI3K/HDAC dual inhibitors against cervical cancer cells.Eur J Med Chem202642715866PubTator, text miningPubMed
A Novel De Novo STAG1 Variant at the RAD21 Binding Interface Is Associated With Hypoglycemia, Recurrent Fever, Immunodeficiency and Features of Classical Cohesinopathies.Clin Genet202642713681PubTator, text miningPubMed
Characterization of Protein Co-Localization and Histone Modifications at Enhancers Anchored in Chromatin Loops.Biology (Basel)202642651636PubTator, text miningPubMed
Exploration of non-hydroxamate based quinoline analogues as HDAC8 inhibitors.RSC Adv202642614841PubTator, text miningPubMed
Outer membrane as a drug target for the treatment of GNB infections.Drug Discov Today202642586474PubTator, text miningPubMed
Chromosome Architecture Defined by the Meiosis-Specific Cohesin in Mammalian Germ Cells.Adv Exp Med Biol202642455438PubTator, text miningPubMed
Development of Indole-3-yl-methylene-thiobarbital Derivatives as Inhibitors of HDAC8 Enzyme Activity.J Med Chem202642406494PubTator, text miningPubMed
Epigenetic regulation of cardiac physiology and pathophysiology: biological sex matters.J Cardiovasc Aging202642369572PubTator, text miningPubMed

1 to 10 of 3,065

See all 3,065 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9126

GET https://conductscience.org/api/genes/v1/9126/patents?page=2