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KCNQ4: potassium voltage-gated channel subfamily Q member 4
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Gene · 9132

Papers891

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

1 to 20 of 891

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TitleJournalYearPMIDFound bySource
Structure-guided mapping of ototoxicity-related proteins: drug entry, damage amplification, cell death execution, and endogenous otoprotection.Hear Res202642800300PubTator, text miningPubMed
Physiological 17β-oestradiol inhibits KV7.4 currents via GPER1-dependent PLC/PKC signalling.Channels (Austin)202642717828PubTator, text miningPubMed
[Advances in research on the molecular mechanisms and gene therapy of hereditary hearing impairment].Zhonghua Yu Fang Yi Xue Za Zhi202642503939PubTator, text miningPubMed
New insights into the complex genetic architecture of age-related hearing loss.Eur J Med Genet202642379497PubTator, text miningPubMed
Etiology-Driven Personalized Cochlear Implantation: Implications for Electrode Choice, Timing, and Outcomes.J Pers Med202641892998PubTator, text miningPubMed
M2 muscarinic receptor-dependent contractions of airway smooth muscle are mediated by inhibition of Kv7 channels.Am J Physiol Cell Physiol202641784087PubTator, text miningPubMed
Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?Int J Mol Sci202641752187PubTator, text miningPubMed
Abnormal Hearing Phenotypes in "Ignorome" Knockout Mice as Predictors of Cognitive Dysfunction.Genes Brain Behav202641738368PubTator, text miningPubMed
Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells.Cancer Cell Int202641736030PubTator, text miningPubMed
Thyroid hormone deficiency induces endolymphatic hydrops: neurological and histopathological evidence from an experimental rat model.Front Neurol202641725713PubTator, text miningPubMed
Genetic and Environmental Factors Shaping Hearing Loss: Xenobiotics, Mechanisms and Translational Perspectives.J Xenobiot202641718270PubTator, text miningPubMed
Deciphering gain-of-function from loss-of-function variants with AlphaMissense: A case study with the mechanosensitive PIEZO1 ion channel protein.Biochem Biophys Rep202641717081PubTator, text miningPubMed
Discovery and Evaluation of E0714 as an Antiepileptic Candidate: A Highly Subtype-Selective Kv7 Agonist within the Kv7 Family Designed Based on a Kv7.2-Specific Pocket.J Med Chem202641711326PubTator, text miningPubMed
Two-step voltage-sensor activation of the human KV7.4 channel and effect of a deafness-associated mutation.Nat Commun202641639121PubTator, text miningPubMed
HAP1 interaction with KCNQ4 attenuates channel surface expression and function.Mol Cells202641619855PubTator, text miningPubMed
A multicenter study reveals a novel pathogenic splice-site founder variant in OTOF.Hum Genomics202541053850PubTator, text miningPubMed
Use of the FLEX 28 Dexamethasone-Eluting Cochlear Implant Electrode in Electric-Acoustic Stimulation: A Case Report.Audiol Res202540981391PubTator, text miningPubMed
acmgscaler: an R package and Colab for standardized gene-level variant effect score calibration within the ACMG/AMP framework.Bioinformatics202540929116PubTator, text miningPubMed
KCNQ4 c.546C>G variant is associated with early-onset high-frequency hearing loss, tinnitus, and cardiovascular comorbidities in Taiwanese adults.Sci Rep202540413265PubTator, text miningPubMed
Hearing loss secondary to novel variants of the KCNQ4 gene.Eur Arch Otorhinolaryngol202540178561PubTator, text miningPubMed

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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