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Gene · 9132

KCNQ4: potassium voltage-gated channel subfamily Q member 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. KCNQ4: potassium voltage-gated channel subfamily Q member 4. Genes, record 9132. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9132

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Gene

Symbol
KCNQ4
HGNC
Name
potassium voltage-gated channel subfamily Q member 4
HGNC
NCBI Gene ID
9132
NCBI Gene
HGNC ID
HGNC:6298
HGNC
Ensembl
ENSG00000117013
NCBI Gene
Aliases
DFNA2, DFNA2A, KV7.4, Kv7.4
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P56696Potassium voltage-gated channel subfamily KQT member 469513Ensembl, GeneID, HGNC

Source UniProt

Patents23

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1458744P56696Espacenet
EP 4641201 A22025-10-291709P56696Espacenet
JP 2025529142 A2025-09-042262P56696Espacenet
US 12371689 B22025-07-292262P56696Espacenet
JP 2025517969 A2025-06-121709P56696Espacenet
US 12281313 B22025-04-2214P56696Espacenet
JP 2024537775 A2024-10-1611P56696Espacenet
JP 2024012440 A2024-01-3014P56696Espacenet
KR 1020220147424 A2022-11-031P56696Espacenet
US 11446398 B22022-09-2065797P56696Espacenet

1 to 10 of 23

See all 23 patents

Drugs10

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AMIFAMPRIDINECHEMBL354077Voltage-gated potassium channel blockerBLOCKERChEMBL
AMIFAMPRIDINE PHOSPHATECHEMBL3301611Voltage-gated potassium channel blockerBLOCKERChEMBL
DALFAMPRIDINECHEMBL284348Voltage-gated potassium channel blockerBLOCKERChEMBL
EZOGABINECHEMBL41355KCNQ (Kv7) potassium channel openerOPENERChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel subunit Kv7.4 activatorACTIVATORChEMBL
FLINDOKALNERCHEMBL266510Voltage-gated potassium channel KCNQ3/KCNQ4 activatorACTIVATORChEMBL
GUANIDINECHEMBL821Voltage-gated potassium channel blockerBLOCKERChEMBL
GUANIDINE HYDROCHLORIDECHEMBL1200728Voltage-gated potassium channel blockerBLOCKERChEMBL
NERISPIRDINECHEMBL2107762Voltage-gated potassium channel blockerBLOCKERChEMBL
TEDISAMILCHEMBL113461Voltage-gated potassium channel blockerBLOCKERChEMBL

Trials96

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07532460DALFAMPRIDINEClinicalTrials.gov
NCT07185347DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT07171203DALFAMPRIDINEPHASE1ClinicalTrials.gov
NCT06853015DALFAMPRIDINEPHASE1/PHASE2ClinicalTrials.gov
NCT06751784DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06596434DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06333171DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06294821DALFAMPRIDINEPHASE2ClinicalTrials.gov
NCT06136728DALFAMPRIDINEPHASE3ClinicalTrials.gov
NCT05919407AMIFAMPRIDINEPHASE3ClinicalTrials.gov

1 to 10 of 96

See all 96 trials

NIH grants604

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleKCNQ4 papersNewest fiscal year
R01DC012049Optimizing Genetic Testing for Deafness for Clinical Diagnostics172025
R35GM130377Ion Channel Transporter Interactions102025
R01NS107671Therapeutic small molecule modulation of Kv channels62025
T32DC000040Research Training Program in Otolaryngology52025
T32HL007446Pathobiology of Occlusive Vascular Disease52025
P30CA054174Mays Cancer Center at UT Health SA42025
R01HL122010Decrypting Variants of Uncertain Significance in Long-QT Syndrome42025
P30DK063491Diabetes Research Center (DRC)32025
R01DC007664Structural Studies of Ion Channel Assembly and Signaling Complexes32025
T32HL086350Training Program in Basic and Translational Cardiovascular Science32025

1 to 10 of 604Source NIH's project files

See all 604 nih grants

Papers891

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structure-guided mapping of ototoxicity-related proteins: drug entry, damage amplification, cell death execution, and endogenous otoprotection.Hear Res202642800300PubTator, text miningPubMed
Physiological 17β-oestradiol inhibits KV7.4 currents via GPER1-dependent PLC/PKC signalling.Channels (Austin)202642717828PubTator, text miningPubMed
[Advances in research on the molecular mechanisms and gene therapy of hereditary hearing impairment].Zhonghua Yu Fang Yi Xue Za Zhi202642503939PubTator, text miningPubMed
New insights into the complex genetic architecture of age-related hearing loss.Eur J Med Genet202642379497PubTator, text miningPubMed
Etiology-Driven Personalized Cochlear Implantation: Implications for Electrode Choice, Timing, and Outcomes.J Pers Med202641892998PubTator, text miningPubMed
M2 muscarinic receptor-dependent contractions of airway smooth muscle are mediated by inhibition of Kv7 channels.Am J Physiol Cell Physiol202641784087PubTator, text miningPubMed
Autophagy in Sensorineural Hearing Loss: Jekyll or Hyde?Int J Mol Sci202641752187PubTator, text miningPubMed
Abnormal Hearing Phenotypes in "Ignorome" Knockout Mice as Predictors of Cognitive Dysfunction.Genes Brain Behav202641738368PubTator, text miningPubMed
Distinct molecular pathways leading to dosage-dependent temozolomide resistance in GBM stem cells.Cancer Cell Int202641736030PubTator, text miningPubMed
Thyroid hormone deficiency induces endolymphatic hydrops: neurological and histopathological evidence from an experimental rat model.Front Neurol202641725713PubTator, text miningPubMed

1 to 10 of 891

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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