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Gene · 9146

HGS: hepatocyte growth factor-regulated tyrosine kinase substrate

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. HGS: hepatocyte growth factor-regulated tyrosine kinase substrate. Genes, record 9146. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/9146

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Gene

Symbol
HGS
HGNC
Name
hepatocyte growth factor-regulated tyrosine kinase substrate
HGNC
NCBI Gene ID
9146
NCBI Gene
HGNC ID
HGNC:4897
HGNC
Ensembl
ENSG00000185359
NCBI Gene
Aliases
HRS, Hrs, Vps27, ZFYVE8
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O14964Hepatocyte growth factor-regulated tyrosine kinase substrate7775Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1448954O14964Espacenet
EP 4650780 A22025-11-195890O14964Espacenet
EP 4641201 A22025-10-295610O14964Espacenet
JP 2025517969 A2025-06-125610O14964Espacenet
JP 2025517970 A2025-06-125890O14964Espacenet
US 11673927 B22023-06-134O14964Espacenet
US 11446398 B22022-09-2037818O14964Espacenet
JP 2022524081 A2022-04-27140789O14964Espacenet
KR 1020220036107 A2022-03-223O14964Espacenet
US 11078247 B22021-08-034963O14964Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,302

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleHGS papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
R01DA012864Mechanisms and Cellular Function of Opioid Receptor Endocytosis72025
R01GM058202Ubiquitin-dependent sorting in endosomes and the TGN62025
K12GM068524San Diego IRACDA Scholars Program52025
P30CA010815Consolidated Basic Cancer Research Program52025
R01NS125016Engineering Extracellular Vesicles of Human Brain Organoids for Stroke Therapy52025
R35GM141832Molecular Basis and Regulatory Mechanisms of Exosome Secretion52025
R35GM127121Cell signaling by G protein-coupled receptors42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30CA008748Cancer Center Support Grant32025

1 to 10 of 1,302Source NIH's project files

See all 1,302 nih grants

Papers1,948

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Photocatalytic CO2 Reduction to Acetone by Chiral HgS/CuO Heterojunctions.Adv Mater202642550127PubTator, text miningPubMed
Advancements in extracellular vesicle research.Extracell Vesicle202642427965PubTator, text miningPubMed
Universal Phonon-Mediated Superconductivity in Compressed Metal Monochalcogenides beyond Anderson Localization.Phys Rev Lett202642412446PubTator, text miningPubMed
Low Handgrip strength and its lifestyle and physiological correlates among Taiwanese University Students: A cross-sectional study.PLoS One202642275307PubTator, text miningPubMed
The ESCRT-0 protein HRS regulates hepatocellular lipid droplet catabolism.Mol Biol Cell202642275204PubTator, text miningPubMed
Two-dimensional HRS condensates drive the assembly of flat clathrin lattices on endosomes.Nat Commun202642120412PubTator, text miningPubMed
TAX1BP1 targets STING1 via microautophagy and Golgiphagy to limit inflammatory signaling.Autophagy202641968678PubTator, text miningPubMed
Tumor exosomes impact functional hallmarks of cancer.Cancer Metastasis Rev202641912733PubTator, text miningPubMed
Mapping Handgrip Strength Research in Sports Performance: A Bibliometric Review of Applications, Trends, and Future Directions.Sports (Basel)202641893592PubTator, text miningPubMed
Extracellular Vesicles Associated Metabolites as Intercellular Signalling Mediators in Disease and Therapy.Metabolites202641893356PubTator, text miningPubMed

1 to 10 of 1,948

See all 1,948 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/9146

GET https://conductscience.org/api/genes/v1/9146/patents?page=2