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Gene · 915

CD3D: CD3 delta subunit of T-cell receptor complex

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. CD3D: CD3 delta subunit of T-cell receptor complex. Genes, record 915. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/915

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Gene

Symbol
CD3D
HGNC
Name
CD3 delta subunit of T-cell receptor complex
HGNC
NCBI Gene ID
915
NCBI Gene
HGNC ID
HGNC:1673
HGNC
Ensembl
ENSG00000167286
NCBI Gene
Aliases
CD3-DELTA, CD3DELTA, IMD19, T3D
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04234T-cell surface glycoprotein CD3 delta chain17131Ensembl, GeneID, HGNC

Source UniProt

Patents608

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026193010 A22026-09-1721P04234Espacenet
EP 4774292 A12026-07-15268P04234Espacenet
EP 4758171 A12026-06-1746P04234Espacenet
EP 4752227 A22026-06-0317P04234Espacenet
JP 2026090249 A2026-06-0224P04234Espacenet
JP 2026516046 A2026-05-1914P04234Espacenet
JP 2026516052 A2026-05-1914P04234Espacenet
JP 2026063132 A2026-04-10319P04234Espacenet
JP 2026511221 A2026-04-105P04234Espacenet
JP 2026054469 A2026-03-2633P04234Espacenet

1 to 10 of 608

See all 608 patents

Drugs16

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BLINATUMOMABCHEMBL1742992T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
CATUMAXOMABCHEMBL2108581T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
ELRANATAMABCHEMBL4297809T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
EPCORITAMABCHEMBL4650393T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
FBT-A05CHEMBL2109351T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
FLOTETUZUMABCHEMBL3990038T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
FORALUMABCHEMBL1743020T cell surface glycoprotein CD3 inhibitorINHIBITORChEMBL
GLOFITAMABCHEMBL4298092T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL
IMC-GP100CHEMBL2109434T cell surface glycoprotein CD3 cross-linking agentCROSS-LINKING AGENTChEMBL
MOSUNETUZUMABCHEMBL4297788T cell surface glycoprotein CD3 binding agentBINDING AGENTChEMBL

1 to 10 of 16

See all 16 drugs

Trials532

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07605416TECLISTAMABPHASE2ClinicalTrials.gov
NCT07598396MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07588698EPCORITAMABPHASE2ClinicalTrials.gov
NCT07581704TECLISTAMABPHASE1ClinicalTrials.gov
NCT07573670BLINATUMOMABPHASE2ClinicalTrials.gov
NCT07566364MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07564453BLINATUMOMABPHASE2ClinicalTrials.gov
NCT07555470MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07548450MOSUNETUZUMABPHASE2ClinicalTrials.gov
NCT07531095TARLATAMABPHASE1ClinicalTrials.gov

1 to 10 of 532

See all 532 trials

NIH grants2,434

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleCD3D papersNewest fiscal year
P30CA016672Cancer Center Support Grant272025
P30CA008748Cancer Center Support Grant262025
P30CA014051Cancer Center Support (Core) Grant112025
UL1TR001863Yale Clinical and Translational Science Award112025
U19AI057229Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro92025
ZIAAI001222Characterization of the cellular and molecular bases of inborn errors of immunity92025
P30AG017265USC/UCLA Center on Biodemography and Population Health82025
R01AI032539Cell Biology of Reovirus Infection82025
P30CA010815Consolidated Basic Cancer Research Program72025
P30CA021765Cancer Center Support Grant (CCSG)72025

1 to 10 of 2,434Source NIH's project files

See all 2,434 nih grants

Papers3,597

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Transcriptomic immune subtyping and connectivity mapping nominate DNA methyltransferase inhibitors for immunedepleted melanoma.Melanoma Res202642777131PubTator, text miningPubMed
Flavokawain B inhibits ER-associated protein dislocation and reduces infectious Zika virus production.Biochem Biophys Res Commun202642679751PubTator, text miningPubMed
Iron Dyshomeostasis and Divergent Antigen Presentation Remodeling in Bronchiectasis: A Dual-Dataset Transcriptomic Analysis.J Inflamm Res202642670432PubTator, text miningPubMed
ICU-acquired infections and mortality in community-acquired pneumonia-induced sepsis: Insights from a transcriptomic analysis.PLoS One202642247411PubTator, text miningPubMed
Clonal lineage tracing of innate immune cells in human cancer.Cancer Cell202642242233PubTator, text miningPubMed
Correlation between DPP-4 Gene Expression and T-Cell Subset Marker Genes in Chronic Liver Disease Patients in Eastern India: An Observational Study.Indian J Endocrinol Metab202642238559PubTator, text miningPubMed
Distinct transcription factors control tissue adaptation and effector function in infant and adult memory T cells.Nat Immunol202642230957PubTator, text miningPubMed
Identification of succinylation-related genes in bladder cancer: integration of single-cell and transcriptomic data.Front Immunol202642220482PubTator, text miningPubMed
Clinical and genetic landscape of SCID in Yunnan, China: identification of two novel RAG2 variants.Sci Rep202642209588PubTator, text miningPubMed
Exploration of CD2 and CD3D as potential immune-related biomarkers for IORT in breast cancer treatment.Medicine (Baltimore)202642065189PubTator, text miningPubMed

1 to 10 of 3,597

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Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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